D-brane Instantons in Type II String Theory

We review recent progress in determining the effects of D-brane instantons in N=1 supersymmetric compactifications of Type II string theory to four dimensions. We describe the abstract D-brane instanton calculus for holomorphic couplings such as the superpotential, the gauge kinetic function and higher fermionic F-terms. This includes a discussion of multi-instanton effects and the implications of background fluxes for the instanton sector. Our presentation also highlights, but is not restricted to the computation of D-brane instanton effects in quiver gauge theories on D-branes at singularities. We then summarize the concrete consequences of stringy D-brane instantons for the construction of semi-realistic models of particle physics or SUSY-breaking in compact and non-compact geometries.Comment: Invited review to appear in Annu.Rev.Nuc.Part.Sci 2009 59; 69 pages, 8 figures, 5 tables; v2: 1 reference adde

Simulation of some quantum gates, with decoherence

Methods and results for numerical simulations of one and two interacting rf-Squid systems suitable for adiabatic quantum gates are presented. These are based on high accuracy numerical solutions to the static and time dependent Schroedinger equation for the full Squid Hamiltonian in one and two variables. Among the points examined in the static analysis is the range of validity of the effective two-state or ``spin 1/2'' picture. A range of parameters is determined where the picture holds to good accuracy as the energy levels undergo gate manipulations. Some general points are presented concerning the relations between device parameters and ``good'' quantum mechanical state spaces. The time dependent simulations allow the examination of suitable conditions for adiabatic behavior, and permits the introduction of a random noise to simulate the effects of decoherence. A formula is derived and tested relating the random noise to the decoherence rate. Sensitivity to device and operating parameters for the logical gates NOT and CNOT are examined, with particular attention to values of the tunnel parameter beta slightly above one. It appears that with values of beta close to one, a quantum CNOT gate is possible even with rather short decoherence times. Many of the methods and results will apply to coupled double-potential well systems in general.Comment: 26 pages, 15 figures, Some clarification added on decoherence treatment, many small errors corrected, symbols on some figures enlarged, refs added. No change in conten

Toward Realistic Intersecting D-Brane Models

We provide a pedagogical introduction to a recently studied class of phenomenologically interesting string models, known as Intersecting D-Brane Models. The gauge fields of the Standard-Model are localized on D-branes wrapping certain compact cycles on an underlying geometry, whose intersections can give rise to chiral fermions. We address the basic issues and also provide an overview of the recent activity in this field. This article is intended to serve non-experts with explanations of the fundamental aspects, and also to provide some orientation for both experts and non-experts in this active field of string phenomenology.Comment: 85 pages, 8 figures, Latex, Bibtex, v2: refs added, typos correcte

Fluxes, Gaugings and Gaugino Condensates

Based on the correspondence between the N = 1 superstring compactifications with fluxes and the N = 4 gauged supergravities, we study effective N = 1 four-dimensional supergravity potentials arising from fluxes and gaugino condensates in the framework of orbifold limits of (generalized) Calabi-Yau compactifications. We give examples in heterotic and type II orientifolds in which combined fluxes and condensates lead to vacua with small supersymmetry breaking scale. We clarify the respective roles of fluxes and condensates in supersymmetry breaking, and analyze the scaling properties of the gravitino mass.Comment: 17 pages, C

Coupling of hard dimers to dynamical lattices via random tensors

We study hard dimers on dynamical lattices in arbitrary dimensions using a random tensor model. The set of lattices corresponds to triangulations of the d-sphere and is selected by the large N limit. For small enough dimer activities, the critical behavior of the continuum limit is the one of pure random lattices. We find a negative critical activity where the universality class is changed as dimers become critical, in a very similar way hard dimers exhibit a Yang-Lee singularity on planar dynamical graphs. Critical exponents are calculated exactly. An alternative description as a system of `color-sensitive hard-core dimers' on random branched polymers is provided.Comment: 12 page

Potential effects of optical solar sail degredation on trajectory design

The optical properties of the thin metalized polymer films that are projected for solar sails are assumed to be affected by the erosive effects of the space environment. Their degradation behavior in the real space environment, however, is to a considerable degree indefinite, because initial ground test results are controversial and relevant inspace tests have not been made so far. The standard optical solar sail models that are currently used for trajectory design do not take optical degradation into account, hence its potential effects on trajectory design have not been investigated so far. Nevertheless, optical degradation is important for high-fidelity solar sail mission design, because it decreases both the magnitude of the solar radiation pressure force acting on the sail and also the sail control authority. Therefore, we propose a simple parametric optical solar sail degradation model that describes the variation of the sail film's optical coefficients with time, depending on the sail film's environmental history, i.e., the radiation dose. The primary intention of our model is not to describe the exact behavior of specific film-coating combinations in the real space environment, but to provide a more general parametric framework for describing the general optical degradation behavior of solar sails. Using our model, the effects of different optical degradation behaviors on trajectory design are investigated for various exemplary missions

D3 instantons in Calabi-Yau orientifolds with(out) fluxes

We investigate the instanton effect due to D3 branes wrapping a four-cycle in a Calabi-Yau orientifold with D7 branes. We study the condition for the nonzero superpotentials from the D3 instantons. For that matter we work out the zero mode structures of D3 branes wrapping a four-cycle both in the presence of the fluxes and in the absence of the fluxes. In the presence of the fluxes, the condition for the nonzero superpotential could be different from that without the fluxes. We explicitly work out a simple example of the orientifold of $K3 \times T^2/Z_2$ with a suitable flux to show such behavior. The effects of D3-D7 sectors are interesting and give further constraints for the nonzero superpotential. In a special configuration where D3 branes and D7 branes wrap the same four-cycle, multi-instanton calculus of D3 branes could be reduced to that of a suitable field theory. The structure of D5 instantons in Type I theory is briefly discussed.Comment: 17 pages; Typos corrected, arguments improved and references adde

Racetrack Inflation

We develop a model of eternal topological inflation using a racetrack potential within the context of type IIB string theory with KKLT volume stabilization. The inflaton field is the imaginary part of the K\"ahler structure modulus, which is an axion-like field in the 4D effective field theory. This model does not require moving branes, and in this sense it is simpler than other models of string theory inflation. Contrary to single-exponential models, the structure of the potential in this example allows for the existence of saddle points between two degenerate local minima for which the slow-roll conditions can be satisfied in a particular range of parameter space. We conjecture that this type of inflation should be present in more general realizations of the modular landscape. We also consider `irrational' models having a dense set of minima, and discuss their possible relevance for the cosmological constant problem.Comment: 23 pages 7 figures. The final version with minor modifications, to appear in JHE

Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap

In eukaryotes the majority of mRNAs have an m7G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism. The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation, and U snRNA export. As little is known about how nuclear CBC mediates the effects of the cap in higher eukaryotes, we have characterized proteins that interact with CBC in HeLa cell nuclear extracts as potential mediators of its function. Using cross-linking and coimmunoprecipitation, we show that eukaryotic translation initiation factor 4G (eIF4G), in addition to its function in the cytoplasm, is a nuclear CBC-interacting protein. We demonstrate that eIF4G interacts with CBC in vitro and that, in addition to its cytoplasmic localization, there is a significant nuclear pool of eIF4G in mammalian cells in vivo. Immunoprecipitation experiments suggest that, in contrast to the cytoplasmic pool, much of the nuclear eIF4G is not associated with eIF4E (translation cap binding protein of eIF4F) but is associated with CBC. While eIF4G stably associates with spliceosomes in vitro and shows close association with spliceosomal snRNPs and splicing factors in vivo, depletion studies show that it does not participate directly in the splicing reaction. Taken together the data indicate that nuclear eIF4G may be recruited to pre-mRNAs via its interaction with CBC and accompanies the mRNA to the cytoplasm, facilitating the switching of CBC for eIF4F. This may provide a mechanism to couple nuclear and cytoplasmic functions of the mRNA cap structure

The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity

Huntington disease is an autosomal dominant neurodegenerative disorder caused by the pathological expansion of a polyglutamine tract. In this study we directly assess the influence of protein size on the formation and subcellular localization of huntingtin aggregates. We have created numerous deletion constructs expressing successively smaller fragments of huntingtin and show that these smaller proteins containing 128 glutamines form both intranuclear and perinuclear aggregates. In contrast, larger NH2-terminal fragments of huntingtin proteins with 128 glutamines form exclusively perinuclear aggregates. These aggregates can form in the absence of endogenous huntingtin. Furthermore, expression of mutant huntingtin results in increased susceptibility to apoptotic stress that is greater with decreasing protein length and increasing polyglutamine size. As both intranuclear and perinuclear aggregates are clearly associated with increased cellular toxicity, this supports an important role for toxic polyglutamine-containing fragments forming aggregates and playing a key role in the pathogenesis of Huntington disease