1,165 research outputs found
Application of natural deep eutectic solvents for the “green”extraction of vanillin from vanilla pods
Plant science
Application of natural deep eutectic solvents for the "green" extraction of vanillin from vanilla pods
Plant science
Aproximación a la identificación de proteinas diferencialmente expresadas en enfermedades de depósito lisosomal.
CO-138
Introducción: Las esfingolipidosis son enfermedades de depósito lisosomal (EDL) caracterizadas por una alteración en el transporte y metabolización de lípidos en el lisosoma y su subsecuente acumulación en el interior de este orgánulo. Son enfermedades de baja prevalencia y mayoritariamente de herencia autosómica recesiva con una gran variabilidad clínica que provoca que, a pesar de poder diagnosticarse en edad pediátrica, hasta en un 40% el diagnóstico se demora hasta la edad adulta. La enfermedad de Gaucher (EG) es la más común entre las EDL, pero también se encuentran otras esfingolipidosis como el déficit de esfingomielinasa ácida (DEMA), la enfermedad de Niemann-Pick tipo C (NPC) en la que el acúmulo de esfingolípidos es secundario a la disfunción lisosomal, o el déficit de lipasa ácida lisosomal (DLAL). En todas ellas existe un importante componente inflamatorio que se traduce en algunos casos por el incremento de inmunoglobulinas o la presencia de gammapatías monoclonales. Se ha prestado poca atención y estudiado escasamente la distribución de las diferentes proteínas séricas en estas entidades. ..
Nuclear parton distributions at next to leading order
We perform a next to leading order QCD global analysis of nuclear deep
inelastic scattering and Drell-Yan data using the convolution approach to
parameterize nuclear parton densities. We find both a significant improvement
in the agreement with data compared to previous extractions, and substantial
differences in the scale dependence of nuclear effects compared to leading
order analyses.Comment: 9 pages, 10 figure
Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup
Mutations of both nuclear and mitochondrial DNA (mtDNA)-encoded mitochondrial proteins can cause cardiomyopathy associated with mitochondrial dysfunction. Hence, the cardiac phenotype of nuclear DNA mitochondrial mutations might be modulated by mtDNA variation. We studied a 13-generation Mennonite pedigree with autosomal recessive myopathy and cardiomyopathy due to an SLC25A4 frameshift null mutation (c.523delC, p.Q175RfsX38), which codes for the heart-muscle isoform of the adenine nucleotide translocator-1. Ten homozygous null (adenine nucleotide translocator-1(-/-)) patients monitored over a median of 6 years had a phenotype of progressive myocardial thickening, hyperalaninemia, lactic acidosis, exercise intolerance, and persistent adrenergic activation. Electrocardiography and echocardiography with velocity vector imaging revealed abnormal contractile mechanics, myocardial repolarization abnormalities, and impaired left ventricular relaxation. End-stage heart disease was characterized by massive, symmetric, concentric cardiac hypertrophy; widespread cardiomyocyte degeneration; overabundant and structurally abnormal mitochondria; extensive subendocardial interstitial fibrosis; and marked hypertrophy of arteriolar smooth muscle. Substantial variability in the progression and severity of heart disease segregated with maternal lineage, and sequencing of mtDNA from five maternal lineages revealed two major European haplogroups, U and H. Patients with the haplogroup U mtDNAs had more rapid and severe cardiomyopathy than those with haplogroup H
The effect of spontaneous collapses on neutrino oscillations
We compute the effect of collapse models on neutrino oscillations. The effect
of the collapse is to modify the evolution of the `spatial' part of the wave
function, which indirectly amounts to a change on the flavor components. In
many respects, this phenomenon is similar to neutrino propagation through
matter. For the analysis we use the mass proportional CSL model, and perform
the calculation to second order perturbation theory. As we will show, the CSL
prediction is very small - mainly due to the very small mass of neutrinos - and
practically undetectable.Comment: 24 pages, RevTeX. Updated versio
Cosmological Effects of Radion Oscillations
We show that the redshift of pressureless matter density due to the expansion
of the universe generically induces small oscillations in the stabilized radius
of extra dimensions (the radion field). The frequency of these oscillations is
proportional to the mass of the radion and can have interesting cosmological
consequences. For very low radion masses () these low frequency oscillations lead to oscillations in
the expansion rate of the universe. The occurrence of acceleration periods
could naturally lead to a resolution of the coincidence problem, without need
of dark energy. Even though this scenario for low radion mass is consistent
with several observational tests it has difficulty to meet fifth force
constraints. If viewed as an effective Brans-Dicke theory it predicts
( is the number of extra dimensions), while
experiments on scales larger than imply . By deriving the
generalized Newtonian potential corresponding to a massive toroidally compact
radion we demonstrate that Newtonian gravity is modified only on scales smaller
than . Thus, these constraints do not apply for
(high frequency oscillations) corresponding to scales less than the current
experiments (). Even though these high frequency oscillations can not
resolve the coincidence problem they provide a natural mechanism for dark
matter generation. This type of dark matter has many similarities with the
axion.Comment: Accepted in Phys. Rev. D. Clarifying comments added in the text and
some additional references include
The relative age effect on physical fitness in preschool children
The aim of the present study was to investigate the existence of a relative age effect (RAE) on physical fitness of preschoolers. Anthropometry and physical fitness were assessed in 3147 children (3–5 years old) using the PREFIT battery. Based on the birth year, participants were divided into 3year groups (3-, 4- and 5-years). Within each year group, 4quarter groups were created: quarter 1, preschoolers born from January to March; quarter 2, from April to June; quarter 3, from July to September; quarter 4, from October to December. The MANCOVA analysis revealed a main effect of year group (Wilks’ ¿ = 0.383; F10, 5996 = 369.64; p < 0.001, ¿p 2 = 0.381) and of quarter (Wilks’ ¿ = 0.874; F15, 8276.6 = 27.67; p < 0.001; ¿p 2 = 0.044) over the whole battery of tests. To the best of our knowledge, this is the first study to report the existence of RAE at the preschool stage. In general, performance improved as the relative age increased (i.e., those born in quarter 1 performed better than those in the other quarters). Individualization strategies should be addressed within the same academic year not only in elementary or secondary years but also in preschoolers
Event Shape/Energy Flow Correlations
We introduce a set of correlations between energy flow and event shapes that
are sensitive to the flow of color at short distances in jet events. These
correlations are formulated for a general set of event shapes, which includes
jet broadening and thrust as special cases. We illustrate the method for
electron-positron annihilation dijet events, and calculate the correlation at
leading logarithm in the energy flow and at next-to-leading-logarithm in the
event shape.Comment: 43 pages, eight eps figures; minor changes, references adde
Cultural contributors to negative emotionality: A multilevel analysis from the Joint Effort Toddler Temperament Consortium
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