1,462 research outputs found

    Pre-Clinical Grades Predict Clinical Performance in the MBBS Stage II Examination at the University of the West Indies, Mona Campus

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    Summary: In the preclinical sciences, statistically significant predictive values have been reported between the performances in one discipline and the others, supporting the hypothesis that students who perform well in one discipline were likely to perform well in the other disciplines. We  therefore decided to conduct a retrospective study to investigate the  predictive effects of preclinical subjects on clinical subjects from 87 students of The University of the West Indies (UWI), Mona Campus who took the MBBS Stage II examination at various times between May 2000 and May 2002. The grade in Pathology was significantly predicted by scores in  Anatomy and Pharmacology; Medicine by Physiology and Pharmacology scores; Surgery by Anatomy and Social and Preventive Medicine scores;  while, the Obstetrics and Gynecology grade was predicted by the Anatomy score. The results support the hypothesis that the scores in some  preclinical subjects can predict the performance in specific clinical subjects, which could be interpreted to suggest that poor performance in specific  preclinical disciplines could be a warning sign of future poor performance in the related clinical disciplines.Keywords: Medical education, preclinical grades, clinical grades, predictors of performanc

    Identification of Myotropic Neuropeptides from the Brain and Corpus Cardiacum-Corpus Allatum Complex of the Beetle, Zophobas atratus

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    The neuropeptide profiles of the two major neuro-endocrinological organs, brain and retrocerebral complex corpus cardiacum-corpus allatum (CC/CA) of adult beetles, Zophobas atratus Fabricius (Coleoptera:Tenebrionidae) were analyzed by a combination of high performance liquid chromatography (HPLC) and matrix-assisted laser desorption ionization time of flight tandem mass spectrometry (MALDI TOF/TOF MS). The homological semi-isolated heart bioassay was used to screen HPLC fractions for myotropic activity in tissues, revealing several cardiostimulatory and cardioinhibitory factors from both the brain and CC/CA. Analysis of HPLC fractions by MALDI-TOF MS identified seven mass ions that could be assigned to other known peptides: leucomyosuppressin (LMS), Tribolium castaneum pyrokinin 2, sulfakinin 1, myoinhibitory peptide 4, a truncated NVP-like peptide, Tenebrio molitor AKH and crustacean cardioactive peptide. In addition, two novel peptides, myosuppressin (pEDVEHVFLRFa), which differs from LMS by one amino acid (E for D at position 4) and pyrokinin-like peptide (LPHYTPRLa) were also identified. To establish cardioactive properties of some of the identified peptides, chemical synthesis was carried out and their activities were tested using the heart bioassay

    Bulk viscous cosmological model with interacting dark fluids

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    The objective of the present work is to study a cosmological model for a spatially flat Universe whose constituents are a dark energy field and a matter field which includes baryons and dark matter. The constituents are supposed to be in interaction and irreversible processes are taken into account through the inclusion of a non-equilibrium pressure. The non-equilibrium pressure is considered to be proportional to the Hubble parameter within the framework of a first order thermodynamic theory. The dark energy and matter fields are coupled by their barotropic indexes, which are considered as functions of the ratio between their energy densities. The free parameters of the model are adjusted from the best fits of the Hubble parameter data. A comparison of the viscous model with the non-viscous one is performed. It is shown that the equality of the dark energy and matter density parameters and the decelerated-accelerated transition occur at earlier times when the irreversible processes are present. Furthermore, the density and deceleration parameters and the distance modulus have the correct behavior which is expected for a viable scenario of the present status of the Universe.Comment: 10 pages, 7 figures, to be published in Brazilian Journal of Physic

    Sub-Planckian black holes and the Generalized Uncertainty Principle

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    The Black Hole Uncertainty Principle correspondence suggests that there could exist black holes with mass beneath the Planck scale but radius of order the Compton scale rather than Schwarzschild scale. We present a modified, self-dual Schwarzschild-like metric that reproduces desirable aspects of a variety of disparate models in the sub-Planckian limit, while remaining Schwarzschild in the large mass limit. The self-dual nature of this solution under M↔M−1M \leftrightarrow M^{-1} naturally implies a Generalized Uncertainty Principle with the linear form Δx∼1Δp+Δp\Delta x \sim \frac{1}{\Delta p} + \Delta p. We also demonstrate a natural dimensional reduction feature, in that the gravitational radius and thermodynamics of sub-Planckian objects resemble that of (1+1)(1+1)-D gravity. The temperature of sub-Planckian black holes scales as MM rather than M−1M^{-1} but the evaporation of those smaller than 10−3610^{-36}g is suppressed by the cosmic background radiation. This suggests that relics of this mass could provide the dark matter.Comment: 12 pages, 9 figures, version published in J. High En. Phy
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