813 research outputs found
Efficient Mixing at low Reynolds numbers using polymer additives
Mixing in fluids is a rapidly developing field of fluid mechanics
\cite{Sreen,Shr,War}, being an important industrial and environmental problem.
The mixing of liquids at low Reynolds numbers is usually quite weak in simple
flows, and it requires special devices to be efficient. Recently, the problem
of mixing was solved analytically for a simple case of random flow, known as
the Batchelor regime \cite{Bat,Kraich,Fal,Sig,Fouxon}. Here we demonstrate
experimentally that very viscous liquids at low Reynolds number, . Here we
show that very viscous liquids containing a small amount of high molecular
weight polymers can be mixed quite efficiently at very low Reynolds numbers,
for a simple flow in a curved channel. A polymer concentration of only 0.001%
suffices. The presence of the polymers leads to an elastic instability
\cite{LMS} and to irregular flow \cite{Ours}, with velocity spectra
corresponding to the Batchelor regime \cite{Bat,Kraich,Fal,Sig,Fouxon}. Our
detailed observations of the mixing in this regime enable us to confirm sevearl
important theoretical predictions: the probability distributions of the
concentration exhibit exponential tails \cite{Fal,Fouxon}, moments of the
distribution decay exponentially along the flow \cite{Fouxon}, and the spatial
correlation function of concentration decays logarithmically.Comment: 11 pages, 5 figure
Dynamics on expanding spaces: modeling the emergence of novelties
Novelties are part of our daily lives. We constantly adopt new technologies,
conceive new ideas, meet new people, experiment with new situations.
Occasionally, we as individuals, in a complicated cognitive and sometimes
fortuitous process, come up with something that is not only new to us, but to
our entire society so that what is a personal novelty can turn into an
innovation at a global level. Innovations occur throughout social, biological
and technological systems and, though we perceive them as a very natural
ingredient of our human experience, little is known about the processes
determining their emergence. Still the statistical occurrence of innovations
shows striking regularities that represent a starting point to get a deeper
insight in the whole phenomenology. This paper represents a small step in that
direction, focusing on reviewing the scientific attempts to effectively model
the emergence of the new and its regularities, with an emphasis on more recent
contributions: from the plain Simon's model tracing back to the 1950s, to the
newest model of Polya's urn with triggering of one novelty by another. What
seems to be key in the successful modelling schemes proposed so far is the idea
of looking at evolution as a path in a complex space, physical, conceptual,
biological, technological, whose structure and topology get continuously
reshaped and expanded by the occurrence of the new. Mathematically it is very
interesting to look at the consequences of the interplay between the "actual"
and the "possible" and this is the aim of this short review.Comment: 25 pages, 10 figure
Cancer incidence in British vegetarians
Background:
Few prospective studies have examined cancer incidence among vegetarians.
Methods:
We studied 61 566 British men and women, comprising 32 403 meat eaters, 8562 non-meat eaters who did eat fish ('fish eaters') and 20 601 vegetarians. After an average follow-up of 12.2 years, there were 3350 incident cancers of which 2204 were among meat eaters, 317 among fish eaters and 829 among vegetarians. Relative risks (RRs) were estimated by Cox regression, stratified by sex and recruitment protocol and adjusted for age, smoking, alcohol, body mass index, physical activity level and, for women only, parity and oral contraceptive use.
Results:
There was significant heterogeneity in cancer risk between groups for the following four cancer sites: stomach cancer, RRs (compared with meat eaters) of 0.29 (95% CI: 0.07–1.20) in fish eaters and 0.36 (0.16–0.78) in vegetarians, P for heterogeneity=0.007; ovarian cancer, RRs of 0.37 (0.18–0.77) in fish eaters and 0.69 (0.45–1.07) in vegetarians, P for heterogeneity=0.007; bladder cancer, RRs of 0.81 (0.36–1.81) in fish eaters and 0.47 (0.25–0.89) in vegetarians, P for heterogeneity=0.05; and cancers of the lymphatic and haematopoietic tissues, RRs of 0.85 (0.56–1.29) in fish eaters and 0.55 (0.39–0.78) in vegetarians, P for heterogeneity=0.002. The RRs for all malignant neoplasms were 0.82 (0.73–0.93) in fish eaters and 0.88 (0.81–0.96) in vegetarians (P for heterogeneity=0.001).
Conclusion:
The incidence of some cancers may be lower in fish eaters and vegetarians than in meat eaters
Fluid Particle Accelerations in Fully Developed Turbulence
The motion of fluid particles as they are pushed along erratic trajectories
by fluctuating pressure gradients is fundamental to transport and mixing in
turbulence. It is essential in cloud formation and atmospheric transport,
processes in stirred chemical reactors and combustion systems, and in the
industrial production of nanoparticles. The perspective of particle
trajectories has been used successfully to describe mixing and transport in
turbulence, but issues of fundamental importance remain unresolved. One such
issue is the Heisenberg-Yaglom prediction of fluid particle accelerations,
based on the 1941 scaling theory of Kolmogorov (K41). Here we report
acceleration measurements using a detector adapted from high-energy physics to
track particles in a laboratory water flow at Reynolds numbers up to 63,000. We
find that universal K41 scaling of the acceleration variance is attained at
high Reynolds numbers. Our data show strong intermittency---particles are
observed with accelerations of up to 1,500 times the acceleration of gravity
(40 times the root mean square value). Finally, we find that accelerations
manifest the anisotropy of the large scale flow at all Reynolds numbers
studied.Comment: 7 pages, 4 figure
A massive proto-cluster of galaxies at a redshift of z {\approx} 5.3
Massive clusters of galaxies have been found as early as 3.9 Billion years
(z=1.62) after the Big Bang containing stars that formed at even earlier
epochs. Cosmological simulations using the current cold dark matter paradigm
predict these systems should descend from "proto-clusters" - early
over-densities of massive galaxies that merge hierarchically to form a cluster.
These proto-cluster regions themselves are built-up hierarchically and so are
expected to contain extremely massive galaxies which can be observed as
luminous quasars and starbursts. However, observational evidence for this
scenario is sparse due to the fact that high-redshift proto-clusters are rare
and difficult to observe. Here we report a proto-cluster region 1 billion years
(z=5.3) after the Big Bang. This cluster of massive galaxies extends over >13
Mega-parsecs, contains a luminous quasar as well as a system rich in molecular
gas. These massive galaxies place a lower limit of >4x10^11 solar masses of
dark and luminous matter in this region consistent with that expected from
cosmological simulations for the earliest galaxy clusters.Comment: Accepted to Nature, 16 Pages, 6 figure
Orientation cues for high-flying nocturnal insect migrants: do turbulence-induced temperature and velocity fluctuations indicate the mean wind flow?
Migratory insects flying at high altitude at night often show a degree of common alignment, sometimes with quite small angular dispersions around the mean. The observed orientation directions are often close to the downwind direction and this would seemingly be adaptive in that large insects could add their self-propelled speed to the wind speed, thus maximising their displacement in a given time. There are increasing indications that high-altitude orientation may be maintained by some intrinsic property of the wind rather than by visual perception of relative ground movement. Therefore, we first examined whether migrating insects could deduce the mean wind direction from the turbulent fluctuations in temperature. Within the atmospheric boundary-layer, temperature records show characteristic ramp-cliff structures, and insects flying downwind would move through these ramps whilst those flying crosswind would not. However, analysis of vertical-looking radar data on the common orientations of nocturnally migrating insects in the UK produced no evidence that the migrants actually use temperature ramps as orientation cues. This suggests that insects rely on turbulent velocity
and acceleration cues, and refocuses attention on how these can be detected, especially as small-scale turbulence is usually held to be directionally invariant (isotropic). In the second part of the paper we present a theoretical analysis and simulations showing that velocity fluctuations and accelerations felt by an insect are predicted to be anisotropic even when the small-scale turbulence (measured at a fixed point or along the trajectory of a fluid-particle) is isotropic. Our results thus provide further evidence that insects do indeed use turbulent velocity and acceleration cues as indicators of the mean wind direction
Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US FDA Adverse Event Reporting System (FAERS) database to detect signals of torsadogenicity for antipsychotics (APs). Methods: Four groups of events in decreasing order of drug-attributable risk were identified: (1) TdP, (2) QT-interval abnormalities, (3) ventricular fibrillation/tachycardia, and (4) sudden cardiac death. The reporting odds ratio (ROR) with 95 % confidence interval (CI) was calculated through a cumulative analysis from group 1 to 4. For groups 1+2, ROR was adjusted for age, gender, and concomitant drugs (e.g., antiarrhythmics) and stratified for AZCERT drugs, lists I and II (http://www.azcert.org, as of June 2011). A potential signal of torsadogenicity was defined if a drug met all the following criteria: (a) four or more cases in group 1+2; (b) significant ROR in group 1+2 that persists through the cumulative approach; (c) significant adjusted ROR for group 1+2 in the stratum without AZCERT drugs; (d) not included in AZCERT lists (as of June 2011). Results: Over the 7-year period, 37 APs were reported in 4,794 cases of arrhythmia: 140 (group 1), 883 (group 2), 1,651 (group 3), and 2,120 (group 4). Based on our criteria, the following potential signals of torsadogenicity were found: amisulpride (25 cases; adjusted ROR in the stratum without AZCERT drugs = 43.94, 95 % CI 22.82-84.60), cyamemazine (11; 15.48, 6.87-34.91), and olanzapine (189; 7.74, 6.45-9.30). Conclusions: This pharmacovigilance analysis on the FAERS found 3 potential signals of torsadogenicity for drugs previously unknown for this risk
Novel avian paramyxovirus isolated from gulls in Caspian seashore in Kazakhstan.
Three isolates APMV/gull/Kazakhstan/5976/2014, APMV/gull/Kazakhstan/ 5977/2014 and APMV/gull/Kazakhstan/5979/2014, were obtained from independent samples during annual surveillance for avian influenza and paramyxoviruses in wild birds from the Caspian Sea coast in Western Kazakhstan, and were initially identified as putative paramyxoviruses on the basis of electron microscopy. Hemagglutination Inhibition Assays with antisera to nine known APMV serotypes (APMV1-9) indicated no relation to any of them. Next generation sequencing of whole genome sequences indicated the three isolates were genetically identical, and had a nucleotide structure typical for all APMVs, consisting of six genes 3'-NP-P-M-F-HN-L-5'. Phylogenetic analyses, and assessment of amino acid identities, suggested the most closely related lineages to be APMV-2, 8, 10 and 15, but the novel isolate had less than 64% identity to them and all other known avian paramyxoviruses. This value was above levels considered to generally define other APMV serotypes. Estimates of the evolutionary divergence of the nucleotide sequences of the genomes of APMVs have shown that novel Kazakhstan APMV strain was closest to APMV-2, APMV-8, APMV-10 and APMV-15, with calculated distance values of 2.057, 2.058, 2.026 and 2.286 respectively, which is above values considered to differentiate other serotypes (observed minimum was 1.108 between APMV-1 and recently isolated APMV/UPO216/Korea). Together, the data suggest that isolate APMV/gull/Kazakhstan/5976/2014 and other two should be considered as the first representative of a novel APMV-20 group, and is the first time that avian paramyxoviruses have been found infecting members of the gull family, extending the known taxonomic host range
The contribution of microlensing surveys to the distance scale
In the early nineties several teams started large scale systematic surveys of
the Magellanic Clouds and the Galactic Bulge to search for microlensing
effects. As a by product, these groups have created enormous time-series
databases of photometric measurements of stars with a temporal sampling
duration and accuracy which are unprecedented. They provide the opportunity to
test the accuracy of primary distance indicators, such as Cepheids, RRLyrae
stars, the detached eclipsing binaries, or the luminosity of the red clump. We
will review the contribution of the microlensing surveys to the understanding
of the physics of the primary distance indicators, recent differential studies
and direct distance determinations to the Magellanic Clouds and the Galactic
Bulge.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in press. 21
pages; uses Kluwer's crckapb.sty LaTeX style file, enclose
Repeated Radionuclide therapy in metastatic paraganglioma leading to the highest reported cumulative activity of 131I-MIBG
131I-MIBG therapy for neuroendocrine tumours may be dose limited. The common range of applied cumulative activities is 10-40 GBq. We report the uneventful cumulative administration of 111 GBq (= 3 Ci) 131I-MIBG in a patient with metastatic paraganglioma. Ten courses of 131I-MIBG therapy were given within six years, accomplishing symptomatic, hormonal and tumour responses with no serious adverse effects. Chemotherapy with cisplatin/vinblastine/dacarbazine was the final treatment modality with temporary control of disease, but eventually the patient died of progression. The observed cumulative activity of 131I-MIBG represents the highest value reported to our knowledge, and even though 12.6 GBq of 90Y-DOTATOC were added intermediately, no associated relevant bone marrow, hepatic or other toxicity were observed. In an individual attempt to palliate metastatic disease high cumulative activity alone should not preclude the patient from repeat treatment
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