2,076 research outputs found
The necessary shift from diagnostic to prognostic research
Background: Do doctors really need to establish an etiological diagnosis each time a patient presents? Or might it often be more effective to treat simply on the basis of symptoms and signs alone, relying on research and on our experience of outcomes for patients who presented in similar ways in the past? Discussion: At a time of increase health care costs especially in pharmaceuticals and expensive diagnostic tests, this article uses examples from recent research to address this question. Our examples come from general practice, because that is where doctors frequently see patients presenting with a yet undifferentiated disease which is consequently difficult to diagnose. The examples include respiratory tract infections, low back pain and shoulder pain. Finally we discuss the 'something is wrong' feeling. Summary: We conclude that, in addition to diagnostic research, a renewed focus on prognostic research is needed. </p
Playing for Data: Ground Truth from Computer Games
Recent progress in computer vision has been driven by high-capacity models
trained on large datasets. Unfortunately, creating large datasets with
pixel-level labels has been extremely costly due to the amount of human effort
required. In this paper, we present an approach to rapidly creating
pixel-accurate semantic label maps for images extracted from modern computer
games. Although the source code and the internal operation of commercial games
are inaccessible, we show that associations between image patches can be
reconstructed from the communication between the game and the graphics
hardware. This enables rapid propagation of semantic labels within and across
images synthesized by the game, with no access to the source code or the
content. We validate the presented approach by producing dense pixel-level
semantic annotations for 25 thousand images synthesized by a photorealistic
open-world computer game. Experiments on semantic segmentation datasets show
that using the acquired data to supplement real-world images significantly
increases accuracy and that the acquired data enables reducing the amount of
hand-labeled real-world data: models trained with game data and just 1/3 of the
CamVid training set outperform models trained on the complete CamVid training
set.Comment: Accepted to the 14th European Conference on Computer Vision (ECCV
2016
Chirped pulse Raman amplification in warm plasma: towards controlling saturation
Stimulated Raman backscattering in plasma is potentially an efficient method of amplifying laser pulses to reach exawatt powers because plasma is fully broken down and withstands extremely high electric fields. Plasma also has unique nonlinear optical properties that allow simultaneous compression of optical pulses to ultra-short durations. However, current measured efficiencies are limited to several percent. Here we investigate Raman amplification of short duration seed pulses with different chirp rates using a chirped pump pulse in a preformed plasma waveguide. We identify electron trapping and wavebreaking as the main saturation mechanisms, which lead to spectral broadening and gain saturation when the seed reaches several millijoules for durations of 10's - 100's fs for 250 ps, 800 nm chirped pump pulses. We show that this prevents access to the nonlinear regime and limits the efficiency, and interpret the experimental results using slowly-varying-amplitude, current-averaged particle-in-cell simulations. We also propose methods for achieving higher efficiencies.close0
The role of chaotic resonances in the solar system
Our understanding of the Solar System has been revolutionized over the past
decade by the finding that the orbits of the planets are inherently chaotic. In
extreme cases, chaotic motions can change the relative positions of the planets
around stars, and even eject a planet from a system. Moreover, the spin axis of
a planet-Earth's spin axis regulates our seasons-may evolve chaotically, with
adverse effects on the climates of otherwise biologically interesting planets.
Some of the recently discovered extrasolar planetary systems contain multiple
planets, and it is likely that some of these are chaotic as well.Comment: 28 pages, 9 figure
Recommended from our members
A Niche-Based Framework to Assess Current Monitoring of European Forest Birds and Guide Indicator Species' Selection
Concern that European forest biodiversity is depleted and declining has provoked widespread efforts to improve management practices. To gauge the success of these actions, appropriate monitoring of forest ecosystems is paramount. Multi-species indicators are frequently used to assess the state of biodiversity and its response to implemented management, but generally applicable and objective methodologies for species' selection are lacking. Here we use a niche-based approach, underpinned by coarse quantification of species' resource use, to objectively select species for inclusion in a pan-European forest bird indicator. We identify both the minimum number of species required to deliver full resource coverage and the most sensitive species' combination, and explore the trade-off between two key characteristics, sensitivity and redundancy, associated with indicators comprising different numbers of species. We compare our indicator to an existing forest bird indicator selected on the basis of expert opinion and show it is more representative of the wider community. We also present alternative indicators for regional and forest type specific monitoring and show that species' choice can have a significant impact on the indicator and consequent projections about the state of the biodiversity it represents. Furthermore, by comparing indicator sets drawn from currently monitored species and the full forest bird community, we identify gaps in the coverage of the current monitoring scheme. We believe that adopting this niche-based framework for species' selection supports the objective development of multi-species indicators and that it has good potential to be extended to a range of habitats and taxa
Immigrant community integration in world cities
As a consequence of the accelerated globalization process, today major cities
all over the world are characterized by an increasing multiculturalism. The
integration of immigrant communities may be affected by social polarization and
spatial segregation. How are these dynamics evolving over time? To what extent
the different policies launched to tackle these problems are working? These are
critical questions traditionally addressed by studies based on surveys and
census data. Such sources are safe to avoid spurious biases, but the data
collection becomes an intensive and rather expensive work. Here, we conduct a
comprehensive study on immigrant integration in 53 world cities by introducing
an innovative approach: an analysis of the spatio-temporal communication
patterns of immigrant and local communities based on language detection in
Twitter and on novel metrics of spatial integration. We quantify the "Power of
Integration" of cities --their capacity to spatially integrate diverse
cultures-- and characterize the relations between different cultures when
acting as hosts or immigrants.Comment: 13 pages, 5 figures + Appendi
Regenerative potential of human muscle stem cells in chronic inflammation
International audienceABSTRACT: INTRODUCTION: Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS: As a model for chronic inflammation, 11 patients suffering from rheumatoid arthritis (RA) were included together with 16 patients with osteoarthritis (OA) as controls. The mean age of both groups was 64 years, with more females in the RA group compared to the OA group. During elective knee replacement surgery, a muscle biopsy was taken from the distal musculus vastus medialis. Cell populations from four RA and eight OA patients were used for extensive phenotyping because these cell populations showed no spontaneous differentiation and myogenic purity greater than 75% after explantation. RESULTS: After mononuclear cell explantation, myogenic purity, viability, proliferation index, number of colonies, myogenic colonies, growth speed, maximum number of population doublings and fusion index were not different between RA and OA patients. Furthermore, the expression of proteins involved in replicative and stress-induced premature senescence and apoptosis, including p16, p21, p53, hTERT and cleaved caspase-3, was not different between RA and OA patients. Mean telomere length was shorter in the RA group compared to the OA group. CONCLUSIONS: In the present study we found evidence that chronic inflammation in RA does not affect the in vitro regenerative potential of human satellite cells. Identification of mechanisms influencing muscle regeneration by modulation of its microenvironment may, therefore, be more appropriate
A descriptive model of patient readiness, motivators, and hepatitis C treatment uptake among Australian prisoners
Background: Hepatitis C virus infection (HCV) has a significant global health burden with an estimated 2%â3% of the world's population infected, and more than 350,000 dying annually from HCV-related conditions including liver failure and liver cancer. Prisons potentially offer a relatively stable environment in which to commence treatment as they usually provide good access to health care providers, and are organised around routine and structure. Uptake of treatment of HCV, however, remains low in the community and in prisons. In this study, we explored factors affecting treatment uptake inside prisons and hypothesised that prisoners have unique issues influencing HCV treatment uptake as a consequence of their incarceration which are not experienced in other populations. Method and Findings: We undertook a qualitative study exploring prisoners' accounts of why they refused, deferred, delayed or discontinued HCV treatment in prison. Between 2010 and 2013, 116 Australian inmates were interviewed from prisons in New South Wales, Queensland, and Western Australia. Prisoners experienced many factors similar to those which influence treatment uptake of those living with HCV infection in the community. Incarceration, however, provides different circumstances of how these factors are experienced which need to be better understood if the number of prisoners receiving treatment is to be increased. We developed a descriptive model of patient readiness and motivators for HCV treatment inside prisons and discussed how we can improve treatment uptake among prisoners.Conclusion: This study identified a broad and unique range of challenges to treatment of HCV in prison. Some of these are likely to be diminished by improving treatment options and improved models of health care delivery. Other barriers relate to inmate understanding of their illness and stigmatisation by other inmates and custodial staff and generally appear less amenable to change although there is potential for peer-based education to address lack of knowledge and stigma
Science that "knows" and science that "asks"
Clinician-researchers and experimental scientists do not speak the same language; they have different professional environments and different end-points in their research. This creates considerable problems of comprehension and communication, which constitute a major drawback in multidisciplinary work such as translational medicine. A stereotypic representation of both these worlds is presented as a starting point to encourage debate on this issue
- âŠ