The Importance of Nutrition in Hypertension

Arterial hypertension (AH) is considered to be one of the most relevant cardiovascular risk factors, and its wide prevalence in all age ranges makes it necessary to analyse all the possible causes and treatments. In this special issue, nutritional interventions are examined either as causes or as treatments of AH. [...]

The source and the age of the soil organic matter of Anthrosols in SW Norway

Recent investigations showed that humus‑rich topsoil’s around the Baltic Sea have been formed by the application of pyrogenic organic matter (Acksel et al., 2016, Geoderma Reg. 7, 187–200) and organic materials (e.g. animal manure, organic waste) linked with human activity and, consequently, these soils were classified as Anthrosols (Acksel et al., 2017 (submitted)). Such humus‑rich topsoil’s, which were strongly influenced by anthropogenic activities and classified as plaggic Anthrosols, were described in SW Norway (Schnepel et al., 2014, J. Plant Nutr. Soil Sci., 177 (4), 638–645.). However, the source and the formation time of the Anthrosols in Norway have not been investigated in detail. Therefore, we characterized the soil organic matter composition by pyrolysis-field ionisation-mass spectrometry (Py-FIMS), benzene polycarboxylic acids (BPCA) determination, examined the source of the SOM by isotopic signatures (d34S) and estimated the age of the SOM by 14C AMS dating in order to find out the beginning of Anthrosol formation. Py-FIMS revealed high portions of sterols and fatty acids, indicating inputs of manure, similar to plaggic Anthrosols in NW Germany. The BC portions (≈ 19 % BC of Corg) were similar to various Anthrosols (≈ 25 % BC of Corg) and Chernozems (≈ 13 % BC of Corg) worldwide and indicated an input of combustion residues to soils by early fire events. The d34S isotope signature of the SOM ranged from 10 to 13.4 ‰ at the islands and 10.6 to 15.2 in the Jaeren region of SW Norway, corresponded to the Anthrosols in the Baltic Sea region (Median: d34S = 11.5 ‰) and indicated an input of marine biomass (d34S of seaweed = 20 ‰). All these results complemented the study of Schnepel et al. (2014) and provided strong evidence that these soils were formed by human activities. Ongoing analyses of 14C ages from these soils enable to estimate the timing of the soil formation and link it to settlement history

GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC3

The Scutum complex in the inner disk of the Galaxy has a number of young star clusters dominated by red supergiants that are heavily obscured by dust extinction and observable only at infrared wavelengths. These clusters are important tracers of the recent star formation and chemical enrichment history in the inner Galaxy. During the technical commissioning and as a first science verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we secured high-resolution (R=50,000) near-infrared spectra of five red supergiants in the young Scutum cluster RSGC3. Taking advantage of the full YJHK spectral coverage of GIANO in a single exposure, we were able to measure several tens of atomic and molecular lines that were suitable for determining chemical abundances. By means of spectral synthesis and line equivalent width measurements, we obtained abundances of Fe and iron-peak elements such as Ni, Cr, and Cu, alpha (O, Mg, Si, Ca, Ti), other light elements (C, N, F, Na, Al, and Sc), and some s-process elements (Y, Sr). We found average half-solar iron abundances and solar-scaled [X/Fe] abundance patterns for most of the elements, consistent with a thin-disk chemistry. We found depletion of [C/Fe] and enhancement of [N/Fe], consistent with standard CN burning, and low 12C/13C abundance ratios (between 9 and 11), which require extra-mixing processes in the stellar interiors during the post-main sequence evolution. We also found local standard of rest V(LSR)=106 km/s and heliocentric V(HEL)=90 km/s radial velocities with a dispersion of 2.3 km/s. The inferred radial velocities, abundances, and abundance patterns of RSGC3 are very similar to those previously measured in the other two young clusters of the Scutum complex, RSGC1 and RSGC2, suggesting a common kinematics and chemistry within the Scutum complex

The minimal N=4 no-scale model from generalized dimensional reduction

We consider the generalized dimensional reduction of pure ungauged N=4, D=5 supergravity, where supersymmetry is spontaneously broken to N=2 or N=0 with identically vanishing scalar potential. We explicitly construct the resulting gauged D=4 theory coupled to a single vector multiplet, which provides the minimal N=4 realization of a no-scale model. We discuss its relation with the standard classification of N=4 gaugings, extensions to non-compact twists and to higher dimensions, the N=2 theories obtained via consistent Z_2 orbifold projections and prospects for further generalizations.Comment: 1+28 pages, no figures, JHEP3 LaTeX, published versio

Role and Efficacy of Intraoperative Evaluation of Resection Adequacy in Conservative Breast Surgery

In the present study we considered the histology of 51 patients who have undergone breast conservative surgery and the related 54 re-excisions that were performed in the same surgical procedure or in delayed procedures, in order to evaluate the role of intraoperative re-excisions in completing tumor removal. In 13% of the cases the re excision obtained the resection of the target lesion. In this study, the occurrence of residual neoplastic lesions in intraoperative re-excisions (24%) is lower than in delayed re-excisions (62%; P = .03). The residual lesions that we could find with definitive histology of re excision specimens are related with lesions with ill defined profile. In 77% of the cases of re excision with tumoral residual the lesion was close to the new resection margin, thus the re-excisions couldn't achieve an adequate ablation of the neoplasm. Invasive or preinvasive nature of the main lesion resected for each case and the approach to the evaluation of the first resection specimen adequacy (surgical or radiological) don't affect the rate of tumoral residual in intraoperative re-excisions. In conclusion, our data are consistent with a low efficacy of intraoperative re excision in obtaining a complete removal of the tumor; intraoperative radiologic evaluation of the first resection specimen is however imperative in defining the effective removal of the target lesion

IMU-based classification of resistive exercises for real-time training monitoring on board the international space station with potential telemedicine spin-off

The microgravity exposure that astronauts undergo during space missions lasting up to 6 months induces biochemical and physiological changes potentially impacting on their health. As a countermeasure, astronauts perform an in-flight training program consisting in different resistive exercises. To train optimally and safely, astronauts need guidance by on-ground specialists via a real-time audio/video system that, however, is subject to a communication delay that increases in proportion to the distance between sender and receiver. The aim of this work was to develop and validate a wearable IMU-based biofeedback system to monitor astronauts in-flight training displaying real-time feedback on exercises execution. Such a system has potential spin-offs also on personalized home/remote training for fitness and rehabilitation. 29 subjects were recruited according to their physical shape and performance criteria to collect kinematics data under ethical committee approval. Tests were conducted to (i) compare the signals acquired with our system to those obtained with the current state-of-the-art inertial sensors and (ii) to assess the exercises classification performance. The magnitude square coherence between the signals collected with the two different systems shows good agreement between the data. Multiple classification algorithms were tested and the best accuracy was obtained using a MultiLayer Perceptron (MLP). MLP was also able to identify mixed errors during the exercise execution, a scenario that is quite common during training. The resulting system represents a novel low-cost training monitor tool that has space application, but also potential use on Earth for individuals working-out at home or remotely thanks to its ease of use and portability

Lines and continuum sky emission in the near infrared: observational constraints from deep high spectral resolution spectra with GIANO-TNG

Aims Determining the intensity of lines and continuum airglow emission in the H-band is important for the design of faint-object infrared spectrographs. Existing spectra at low/medium resolution cannot disentangle the true sky-continuum from instrumental effects (e.g. diffuse light in the wings of strong lines). We aim to obtain, for the first time, a high resolution infrared spectrum deep enough to set significant constraints on the continuum emission between the lines in the H-band. Methods During the second commissioning run of the GIANO high-resolution infrared spectrograph at La Palma Observatory, we pointed the instrument directly to the sky and obtained a deep spectrum that extends from 0.97 to 2.4 micron. Results The spectrum shows about 1500 emission lines, a factor of two more than in previous works. Of these, 80% are identified as OH transitions; half of these are from highly excited molecules (hot-OH component) that are not included in the OH airglow emission models normally used for astronomical applications. The other lines are attributable to O2 or unidentified. Several of the faint lines are in spectral regions that were previously believed to be free of line emission. The continuum in the H-band is marginally detected at a level of about 300 photons/m^2/s/arcsec^2/micron, equivalent to 20.1 AB-mag/arcsec^2. The observed spectrum and the list of observed sky-lines are published in electronic format. Conclusions Our measurements indicate that the sky continuum in the H-band could be even darker than previously believed. However, the myriad of airglow emission lines severely limits the spectral ranges where very low background can be effectively achieved with low/medium resolution spectrographs. We identify a few spectral bands that could still remain quite dark at the resolving power foreseen for VLT-MOONS (R ~6,600).Comment: 7 pages, 4 figures, to be published in Astronomy & Astrophysic

Phytochemical profile, antioxidant and antidiabetic activities of Adansonia digitata L. (baobab) from Mali, as source of health-promoting compounds

Background: Adansonia digitata L. (Malvaceae), also known as baobab, is a tree attracting recent interest especially due to the high nutritional value of the fruit pulp. However, few studies are reported on the secondary metabolite content, showing high variability due to geographic region. Methods: In this study, the chemical profiles of Malian commercial baobab fruits and leaves, focused on phenolic content, were investigated by HPLC coupled with a photodiode array (PDA)/UV and an electrospray ionization (ESI) mass spectrometer (MS) and gas chromatography (GC)/MS. In addition, the extracts of fruit pulps obtained from three different markets (Fruits 1, 2, and 3) were evaluated for their total phenolic content (TPC), antioxidant activity and α-glucosidase inhibition. Results: Baobab fruit pulps were found to be rich in procyanidins and flavonol glycosides, with tiliroside as the major constituent. The baobab leaves showed a similar profile respect to the fruits, but with more detected phenolics. All fruit pulp extracts exerted antioxidant activity (highest for Fruit 3) and higher α-glucosidase inhibition than acarbose used as standard. Conclusions: This study confirmed the variability of baobab with different origins and indicated Malian species baobab as promising source of health-promoting substances