50 research outputs found
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-basedx-acidic amino acids as glutamate receptors ligands
Get PDFA novel series of bicyclo[1.1.1]pentane-based x-acidic amino acids, including (2S)- and (2R)-3-(30-carboxybicyclo[
1.1.1]pentyl)alanines (8 and 9), (2S)- and (2R)-2-(30-carboxymethylbicyclo[1.1.1]pentyl)glycines
(10 and 11), and (2S)- and (2R)-3-(30-phosphonomethylbicyclo[1.1.1]pentyl)glycines (12 and 13),
were synthesized and evaluated as glutamate receptor ligands. Among them, (2R)-3-(30-phosphonomethylbicyclo[
1.1.1]pentyl)glycine (13) showed relatively high affinity and selectivity at the NMDA
receptor. The results are also discussed in light of pharmacophoric modelling studies of NMDA agonists
and antagonists
<em>Hideko Mizuno e le origini dell’</em>ongaku manga (Hideko Mizuno and the birth of the <em>ongaku manga</em>)
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Genetic polymorphisms of renin-angiotensin-aldosterone and sympathetic nervous systems in early ischemic stroke
No full textβ-2 adrenergic receptor gene polymorphism may modulate sympathetic effects: an haplotype analysis.
No full textPossibile associazione di fenotipi ipertrofici cardiovascolari con un polimorfismo genetico dell’aldosterone sintetasi (CYP11B2 T/C –344).
No full textAnalisi aplotipica della variabilità genetica del recettore beta 2 adrenergico in rapporto a fenotipi cardiovascolari
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Association of β1-adrenergic receptor polymorphism with blood pressure and left ventricular mass in a population study
No full text9nonenoneM. Castellano; F. Rossi; M. Giacchè; F. Rivadossi; C. Perani; M.L. Muiesan; M. Beschi; D. Rizzoni; E. Agabiti RoseiCastellano, Maurizio; Rossi, Federica; M., Giacchè; Rivadossi, Francesca; C., Perani; Muiesan, Maria Lorenza; M., Beschi; Rizzoni, Damiano; AGABITI ROSEI, Enric
Relationship of an aldosterone synthase gene polymorphism with cardiovascular hypertrophic changes.
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