Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema: interim analysis of the RESTORE extension study

To evaluate the 2-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema (DME)

Evidence of Sex-specific Differences in Masticatory Jaw Movement Patterns

The complexity of human oral functional movements has not been studied in detail quantitatively, and only recently have studies begun to evaluate whether such movements contain sex-specific characteristics. Therefore, the purposes of this study were: (1) to quantify in detail the jaw movements and associated masticatory electromyographic activity occurring during gum chewing, and (2) to explore these data for evidence of sex specificity. Fourteen male and 17 female subjects participated in the study. Approximately 11 right- and 11 left-sided chewing cycles and associated masticatory electromyographic activity were sampled from each subject. The samples were quantified into 165 variables per chewing cycle, averaged to create a single multivariate vector for each subject, and then analyzed by a step-wise discriminant analysis. With a combination of 6 variables, a jackknifed cross-validation test found the probability of correct classification to be 93.5%. These findings support the hypothesis that masticatory jaw movements contain sex-specific features.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66870/2/10.1177_00220345970760031301.pd

Paternalistic Leadership: A Review and Agenda for Future Research

The growing interest in paternalistic leadership research has led to a recent proliferation of diverse definitions and perspectives, as well as a limited number of empirical studies. Consequently, the diversity of perspectives has resulted in conceptual ambiguities, as well as contradictory empirical findings. In this article, the authors review research on paternalistic leadership in an effort to assess the current state of the literature. They investigate the construct of paternalistic leadership and review the findings related to its outcomes and antecedents as well as the various measurement scales used in paternalistic leadership research. On the basis of this review, the article concludes with an agenda for future theoretical and empirical research on this emerging and intriguing new area for leadership research