Explaining LIGO's observations via isolated binary evolution with natal kicks

We compare binary evolution models with different assumptions about black-hole natal kicks to the first gravitational-wave observations performed by the LIGO detectors. Our comparisons attempt to reconcile merger rate, masses, spins, and spin-orbit misalignments of all current observations with state-of-the-art formation scenarios of binary black holes formed in isolation. We estimate that black holes (BHs) should receive natal kicks at birth of the order of $\sigma\simeq 200$ (50) km/s if tidal processes do (not) realign stellar spins. Our estimate is driven by two simple factors. The natal kick dispersion $\sigma$ is bounded from above because large kicks disrupt too many binaries (reducing the merger rate below the observed value). Conversely, the natal kick distribution is bounded from below because modest kicks are needed to produce a range of spin-orbit misalignments. A distribution of misalignments increases our models' compatibility with LIGO's observations, if all BHs are likely to have natal spins. Unlike related work which adopts a concrete BH natal spin prescription, we explore a range of possible BH natal spin distributions. Within the context of our models, for all of the choices of $\sigma$ used here and within the context of one simple fiducial parameterized spin distribution, observations favor low BH natal spin.Comment: 19 pages, 14 figures, as published in PR

Multi-timescale analysis of phase transitions in precessing black-hole binaries

This is the author accepted manuscript. The final version is available from APS via http://dx.doi.org/10.1103/PhysRevD.92.064016The dynamics of precessing binary black holes (BBHs) in the post-Newtonian regime has a strong timescale hierarchy: the orbital timescale is very short compared to the spin-precession timescale which, in turn, is much shorter than the radiation-reaction timescale on which the orbit is shrinking due to gravitational-wave emission. We exploit this timescale hierarchy to develop a multi-scale analysis of BBH dynamics elaborating on the analysis of Kesden et al. (2015). We solve the spin-precession equations analytically on the precession time and then implement a quasi-adiabatic approach to evolve these solutions on the longer radiation-reaction time. This procedure leads to an innovative "precession-averaged" post-Newtonian approach to studying precessing BBHs. We use our new solutions to classify BBH spin precession into three distinct morphologies, then investigate phase transitions between these morphologies as BBHs inspiral. These precession-averaged post-Newtonian inspirals can be efficiently calculated from arbitrarily large separations, thus making progress towards bridging the gap between astrophysics and numerical relativity.D.G. is supported by the UK STFC and the Isaac Newton Studentship of the University of Cambridge. M.K. is supported by Alfred P. Sloan Foundation grant FG-2015-65299. R.O'S. is supported by NSF grants PHY-0970074 and PHY-1307429. E.B. is sup- ported by NSF CAREER Grant PHY-1055103 and by FCT contract IF/00797/2014/CP1214/CT0012 under the IF2014 Programme. U.S. is supported by FP7- PEOPLE-2011-CIG Grant No. 293412, FP7-PEOPLE- 2011-IRSES Grant No.295189, H2020 ERC Consolida- tor Grant Agreement No. MaGRaTh-646597, SDSC and TACC through XSEDE Grant No. PHY-090003 by the NSF, Finis Terrae through Grant No. ICTS- CESGA-249, STFC Roller Grant No. ST/L000636/1 and DiRAC's Cosmos Shared Memory system through BIS Grant No. ST/J005673/1 and STFC Grant Nos. ST/H008586/1, ST/K00333X/1

Communication: Hole localization in Al-doped quartz SiO2 within ab initio hybrid-functional DFT

We investigate the long-standing problem of the hole localization at the Al impurity in quartz SiO$_2$, using a relatively recent DFT hybrid-functional method in which the exchange fraction is obtained \emph{ab initio}, based on an analogy with the static many-body COHSEX approximation to the electron self-energy. As the amount of the admixed exact exchange in hybrid functionals has been shown to be determinant for properly capturing the hole localization, this problem constitutes a prototypical benchmark for the accuracy of the method, allowing one to assess to what extent self-interaction effects are avoided. We obtain good results in terms of description of the charge localization and structural distortion around the Al center, improving with respect to the more popular B3LYP hybrid-functional approach. We also discuss the accuracy of computed hyperfine parameters, by comparison with previous calculations based on other self-interaction-free methods, as well as experimental values. We discuss and rationalize the limitations of our approach in computing defect-related excitation energies in low-dielectric-constant insulators.Comment: Accepted for publication in J. Chem. Phys. (Communications

The Digital Image Correlation technique applied to the deformation behavior of welded sheet joints

The existence of a welded zone generally influences the local strain and stress distribution especially in case of welding defects. A method able to measure the local deformability can hence give many important information about the real stress and strain fields useful to improve the welded structure design. In this experimental work, some new generation automotive steels have been considered, because of the well known welding problems due to their unstable microstructural condition. Such materials, known as Q&P steels and available only as thin sheets, require a suitable quenching process able to give high mechanical resistance and satisfying deformability. Some sheet samples were welded by electron beam technique, because it is able to reduce the width of the heat affected zone where the main microstructural changes are concentrated. From such samples, tensile specimens were machined. During the tensile tests, the deformations were measured both by a traditional extensometer and by a 3D Digital Image Correlation (3D DIC) technique. A preliminary investigation of the melted and the heat affected zones resulted in small dimensions (about 10 mm) and hence the measuring setup has been optimized in order maximize the achievable measuring resolution minimizing the resulting uncertainty. This result can be achieved by a pattern generated by a suitable software and by an accurate preparation of the surface where the pattern will be deposited on

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Decellularized aortic conduits: could their cryopreservation affect post-implantation outcomes? A morpho-functional study on porcine homografts

Decellularized porcine aortic valve conduits (AVCs) implanted in a Vietnamese Pig (VP) experimental animal model were matched against decellularized and then cryopreserved AVCs to assess the effect of cryopreservation on graft hemodynamic performance and propensity to in vivo repopulation by host\u2019s cells. VPs (n = 12) underwent right ventricular outflow tract substitution using AVC allografts and were studied for 15-month follow-up. VPs were randomized into two groups, receiving AVCs treated with decellularization alone (D; n = 6) or decellularization/cryopreservation (DC; n = 6), respectively. Serial echocardiography was carried out to follow up hemodynamic function. All explanted AVCs were processed for light and electron microscopy. No signs of dilatation, progressive stenosis, regurgitation, and macroscopic calcification were echocardiographically observed in both D and DC groups. Explanted D grafts exhibited near-normal features, whereas the presence of calcification, inflammatory infiltrates, and disarray of elastic lamellae occurred in some DC grafts. In the unaltered regions of AVCs from both groups, almost complete re-endothelialization was observed for both valve cusps and aorta walls. In addition, side-by-side repopulation by recipient\u2019s fibroblasts, myofibroblasts, and smooth muscle cells was paralleled by ongoing tissue remodeling, as revealed by the ultrastructural identification of typical canals of collagen fibrillogenesis and elastogenesis-related features. Incipient neo-vascularization and re-innervation of medial and adventitial tunicae of grafted aortic walls were also detected for both D and DC groups. Cryopreservation did not affect post-implantation AVC hemodynamic behavior and was topically propensive to cell repopulation and tissue renewal, although graft deterioration including calcification was present in several areas. Thus, these preliminary data provide essential information on feasibility of decellularization and cryopreservation coupling in the perspective of treatment optimization and subsequent clinical trials using similarly treated human allografts as innovative heart valve substitutes