Bioluminescence in Melosira varians Ag.

Bluish green bioluminescence in a diatom, Melosira varians Ag. growing in an abandoned tin mine in Cornwall was observed. Upon microscopic examination the chloroplasts of the algae were found to be very pale but no other feature was seen which could be correlated with the luminescence

Quantization of a self-interacting maximally charged string

We discuss the quantization of a self-interacting string consisting of maximally charged matter. We construct the Hamiltonian in the non-relativistic limit by expanding around a static solution of the Einstein-Maxwell field equations. Conformal symmetry is broken on the worldsheet, but a subgroup of the conformal group acts as the gauge group of the theory. Thus, the Faddeev-Popov quantization procedure of fixing the gauge is applicable. We calculate the Hamiltonian and show that, if properly quantized, the system possesses a well-defined ground state and the spacing of its energy levels is of order the Planck mass. This generalizes earlier results on a system of maximally charged black holes to the case of continuous matter distributions.Comment: 11 page

Canonical quantization of a particle near a black hole

We discuss the quantization of a particle near an extreme Reissner-Nordstrom black hole in the canonical formalism. This model appears to be described by a Hamiltonian with no well-defined ground state. This problem can be circumvented by a redefinition of the Hamiltonian due to de Alfaro, Fubini and Furlan (DFF). We show that the Hamiltonian with no ground state corresponds to a gauge in which there is an obstruction at the boundary of spacetime requiring a modification of the quantization rules. The redefinition of the Hamiltonian a la DFF corresponds to a different choice of gauge. The latter is a good gauge leading to standard quantization rules. Thus, the DFF trick is a consequence of a standard gauge-fixing procedure in the case of black hole scattering.Comment: 13 pages, ReVTeX, no figure

Quantization of maximally-charged slowly-moving black holes

We discuss the quantization of a system of slowly-moving extreme Reissner-Nordstrom black holes. In the near-horizon limit, this system has been shown to possess an SL(2,R) conformal symmetry. However, the Hamiltonian appears to have no well-defined ground state. This problem can be circumvented by a redefinition of the Hamiltonian due to de Alfaro, Fubini and Furlan (DFF). We apply the Faddeev-Popov quantization procedure to show that the Hamiltonian with no ground state corresponds to a gauge in which there is an obstruction at the singularities of moduli space requiring a modification of the quantization rules. The redefinition of the Hamiltonian a la DFF corresponds to a different choice of gauge. The latter is a good gauge leading to standard quantization rules. Thus, the DFF trick is a consequence of a standard gauge-fixing procedure in the case of black hole scattering.Comment: Corrected errors in the gauge-fixing procedur

Cytochrome P450associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae.

The role of cuticle changes in insecticide resistance in the major malaria vector Anopheles gambiae was assessed. The rate of internalization of 14C deltamethrin was significantly slower in a resistant strain than in a susceptible strain. Topical application of an acetone insecticide formulation to circumvent lipid-based uptake barriers decreased the resistance ratio by ∼50%. Cuticle analysis by electron microscopy and characterization of lipid extracts indicated that resistant mosquitoes had a thicker epicuticular layer and a significant increase in cuticular hydrocarbon (CHC) content (∼29%). However, the CHC profile and relative distribution were similar in resistant and susceptible insects. The cellular localization and in vitro activity of two P450 enzymes, CYP4G16 and CYP4G17, whose genes are frequently overexpressed in resistant Anopheles mosquitoes, were analyzed. These enzymes are potential orthologs of the CYP4G1/2 enzymes that catalyze the final step of CHC biosynthesis in Drosophila and Musca domestica, respectively. Immunostaining indicated that both CYP4G16 and CYP4G17 are highly abundant in oenocytes, the insect cell type thought to secrete hydrocarbons. However, an intriguing difference was indicated; CYP4G17 occurs throughout the cell, as expected for a microsomal P450, but CYP4G16 localizes to the periphery of the cell and lies on the cytoplasmic side of the cell membrane, a unique position for a P450 enzyme. CYP4G16 and CYP4G17 were functionally expressed in insect cells. CYP4G16 produced hydrocarbons from a C18 aldehyde substrate and thus has bona fide decarbonylase activity similar to that of dmCYP4G1/2. The data support the hypothesis that the coevolution of multiple mechanisms, including cuticular barriers, has occurred in highly pyrethroid-resistant An. gambiae.Fil: Balabanidou, Vasileia. Foundation for Research and Technology-Hellas; Grecia. Universidad de Creta; GreciaFil: Kampouraki, Anastasia. Universidad de Creta; GreciaFil: Mac Lean, Marina. University of Nevada; Estados UnidosFil: Blomquist, Gary J.. University of Nevada; Estados UnidosFil: Tittiger, Claus. University of Nevada; Estados UnidosFil: Juarez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Chalepakis, George. Universidad de Creta; GreciaFil: Anthousi, Amalia. Universidad de Creta; GreciaFil: Lynd, Amy. Liverpool School of Tropical Medicine; Reino UnidoFil: Antoine, Sanou. Liverpool School of Tropical Medicine; Reino UnidoFil: Hemingway, Janet. Liverpool School of Tropical Medicine; Reino UnidoFil: Ranson, Hilary. Liverpool School of Tropical Medicine; Reino UnidoFil: Lycett, Gareth J.. Liverpool School of Tropical Medicine; Reino UnidoFil: Vontas, John. Foundation for Research and Technology-Hellas; Grecia. Agricultural University of Athens; Greci

The Radial Distribution of the Interstellar Medium in Disk Galaxies: Evidence for Secular Evolution

One possible way for spiral galaxies to internally evolve would be for gas to flow to the center and form stars in a central disk (pseudo-bulge). If the inflow rate is faster than the rate of star formation, a central concentration of gas will form. In this paper we present radial profiles of stellar and 8 μm emission from polycyclic aromatic hydrocarbons (PAHs) for 11 spiral galaxies to investigate whether the interstellar medium in these galaxies contains a central concentration above that expected from the exponential disk. In general, we find that the two-dimensional CO and PAH emission morphologies are similar, and that they exhibit similar radial profiles. We find that in 6 of the 11 galaxies there is a central excess in the 8 μm and CO emission above the inward extrapolation of an exponential disk. In particular, all four barred galaxies in the sample have strong central excesses in both 8 μm and CO emission. These correlations suggest that the excess seen in the CO profiles is, in general, not simply due to a radial increase in the CO emissivity. In the inner disk, the ratio of the stellar to the 8 μm radial surface brightness is similar for 9 of the 11 galaxies, suggesting a physical connection between the average stellar surface brightness and the average gas surface brightness at a given radius. We also find that the ratio of the CO to 8 μm PAH surface brightness is consistent over the sample, implying that the 8 μm PAH surface brightness can be used as an approximate tracer of the interstellar medium

Warm Dust and Spatially Variable PAH Emission in the Dwarf Starburst Galaxy NGC 1705

We present Spitzer observations of the dwarf starburst galaxy NGC 1705 obtained as part of SINGS. The galaxy morphology is very different shortward and longward of ~5 microns: short-wavelength imaging shows an underlying red stellar population, with the central super star cluster (SSC) dominating the luminosity; longer-wavelength data reveals warm dust emission arising from two off-nuclear regions offset by ~250 pc from the SSC. These regions show little extinction at optical wavelengths. The galaxy has a relatively low global dust mass (~2E5 solar masses, implying a global dust-to-gas mass ratio ~2--4 times lower than the Milky Way average). The off-nuclear dust emission appears to be powered by photons from the same stellar population responsible for the excitation of the observed H Alpha emission; these photons are unassociated with the SSC (though a contribution from embedded sources to the IR luminosity of the off-nuclear regions cannot be ruled out). Low-resolution IRS spectroscopy shows moderate-strength PAH emission in the 11.3 micron band in the eastern peak; no PAH emission is detected in the SSC or the western dust emission complex. There is significant diffuse 8 micron emission after scaling and subtracting shorter wavelength data; the spatially variable PAH emission strengths revealed by the IRS data suggest caution in the interpretation of diffuse 8 micron emission as arising from PAH carriers alone. The metallicity of NGC 1705 falls at the transition level of 35% solar found by Engelbracht and collaborators; the fact that a system at this metallicity shows spatially variable PAH emission demonstrates the complexity of interpreting diffuse 8 micron emission. A radio continuum non-detection, NGC 1705 deviates significantly from the canonical far-IR vs. radio correlation. (Abridged)Comment: ApJ, in press; please retrieve full-resolution version from http://www.astro.wesleyan.edu/~cannon/pubs.htm

Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component

Activation-induced cytidine deaminase (AID) is expressed in B cells within germinal centers and is critically involved in class switch recombination and somatic hypermutation of immunoglobulin loci. Functionally active AID can additionally be detected within ectopic follicular structures developed at sites of chronic inflammation. Furthermore, AID may target non-Ig genes in B- and non-B-cell background. Therefore, AID-associated effects are of increasing interest in disease areas such as allergy, inflammation, autoimmunity, and cancer