3,062 research outputs found
Seagrass can mitigate negative ocean acidification effects on calcifying algae
The ultimate effect that ocean acidification (OA) and warming will have on the physiology of calcifying algae is still largely uncertain. Responses depend on the complex interactions between seawater chemistry, global/local stressors and species-specific physiologies. There is a significant gap regarding the effect that metabolic interactions between coexisting species may have on local seawater chemistry and the concurrent effect of OA. Here, we manipulated CO2 and temperature to evaluate the physiological responses of two common photoautotrophs from shallow tropical marine coastal ecosystems in Brazil: the calcifying alga Halimeda cuneata, and the seagrass Halodule wrightii. We tested whether or not seagrass presence can influence the calcification rate of a widespread and abundant species of Halimeda under OA and warming. Our results demonstrate that under elevated CO2, the high photosynthetic rates of H. wrightii contribute to raise H. cuneata calcification more than two-fold and thus we suggest that H. cuneata populations coexisting with H. wrightii may have a higher resilience to OA conditions. This conclusion supports the more general hypothesis that, in coastal and shallow reef environments, the metabolic interactions between calcifying and non-calcifying organisms are instrumental in providing refuge against OA effects and increasing the resilience of the more OA-susceptible species.E.B. would like to thank the Coordenação de Aperfeiçoamento de Pessoas de Nível Superior (CAPES) for Masters
funding. Funding for this project came from the Synergism grant (CNPq 407365/2013-3). We extend our thanks
to the Brazil-based Projeto Coral Vivo and its sponsor PetroBras Ambiental for providing the Marine Mesocosm
structure and experimental assistance.info:eu-repo/semantics/publishedVersio
A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases
This project was supported by grants from the Wellcome Trust and the Medical Research Council UK (G.F.). J.S.C. and L.Y. are supported by the Wellcome Trust (079643/Z/06/Z)
Common Origin of Soft mu-tau and CP Breaking in Neutrino Seesaw and the Origin of Matter
Neutrino oscillation data strongly support mu-tau symmetry as a good
approximate flavor symmetry of the neutrino sector, which has to appear in any
viable theory for neutrino mass-generation. The mu-tau breaking is not only
small, but also the source of Dirac CP-violation. We conjecture that both
discrete mu-tau and CP symmetries are fundamental symmetries of the seesaw
Lagrangian (respected by interaction terms), and they are only softly broken,
arising from a common origin via a unique dimension-3 Majorana mass-term of the
heavy right-handed neutrinos. From this conceptually attractive and simple
construction, we can predict the soft mu-tau breaking at low energies, leading
to quantitative correlations between the apparently two small deviations
\theta_{23} - 45^o and \theta_{13} - 0^o. This nontrivially connects the
on-going measurements of mixing angle \theta_{23} with the upcoming
experimental probes of \theta_{13}. We find that any deviation of \theta_{23} -
45^o must put a lower limit on \theta_{13}. Furthermore, we deduce the low
energy Dirac and Majorana CP violations from a common soft-breaking phase
associated with mu-tau breaking in the neutrino seesaw. Finally, from the soft
CP breaking in neutrino seesaw we derive the cosmological CP violation for the
baryon asymmetry via leptogenesis. We fully reconstruct the leptogenesis
CP-asymmetry from the low energy Dirac CP phase and establish a direct link
between the cosmological CP-violation and the low energy Jarlskog invariant. We
predict new lower and upper bounds on the \theta_{13} mixing angle, 1^o <
\theta_{13} < 6^o. In addition, we reveal a new hidden symmetry that dictates
the solar mixing angle \theta_12 by its group-parameter, and includes the
conventional tri-bimaximal mixing as a special case, allowing deviations from
it.Comment: 60pp, JCAP in Press, v2: only minor stylistic refinements (added Daya
Bay's future sensitivity in Figs.2+8, shortened some eqs, added new
Appendix-A and some references), comments are welcome
Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells
Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells’ proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region
Lens epithelium-derived growth factor/p75 (LEDGF/p75) is a transcriptional coactivator involved in stress response, autoimmune disease, cancer and HIV replication. A fusion between the nuclear pore protein NUP98 and LEDGF/p75 has been found in human acute and chronic myeloid leukemia and association of LEDGF/p75 with mixed-lineage leukemia (MLL)/menin is critical for leukemic transformation. During lentiviral replication, LEDGF/p75 tethers the pre-integration complex to the host chromatin resulting in a bias of integration into active transcription units (TUs). The consensus function of LEDGF/p75 is tethering of cargos to chromatin. In this regard, we determined the LEDGF/p75 chromatin binding profile. To this purpose, we used DamID technology and focused on the highly annotated ENCODE (Encyclopedia of DNA Elements) regions. LEDGF/p75 primarily binds downstream of the transcription start site of active TUs in agreement with the enrichment of HIV-1 integration sites at these locations. We show that LEDGF/p75 binding is not restricted to stress response elements in the genome, and correlation analysis with more than 200 genomic features revealed an association with active chromatin markers, such as H3 and H4 acetylation, H3K4 monomethylation and RNA polymerase II binding. Interestingly, some associations did not correlate with HIV-1 integration indicating that not all LEDGF/p75 complexes on the chromosome are amenable to HIV-1 integration
Effects of Degraded Optical Conditions on Behavioural Responses to Alarm Cues in a Freshwater Fish
Prey organisms often use multiple sensory cues to gain reliable information about imminent predation threat. In this study we test if a freshwater fish increases the reliance on supplementary cues when the reliability of the primary cue is reduced. Fish commonly use vision to evaluate predation threat, but may also use chemical cues from predators or injured conspecifics. Environmental changes, such as increasing turbidity or water colour, may compromise the use of vision through changes in the optical properties of water. In an experiment we tested if changes in optical conditions have any effects on how crucian carp respond to chemical predator cues. In turbidity treatments we added either clay or algae, and in a brown water colour treatment we added water with a high humic content. We found that carp reduced activity in response to predator cues, but only in the turbidity treatments (clay, algae), whereas the response in the brown water treatment was intermediate, and not significantly different from, clear and turbid water treatments. The increased reliance on chemical cues indicates that crucian carp can compensate for the reduced information content from vision in waters where optical conditions are degraded. The lower effect in brown water may be due to the reduction in light intensity, changes in the spectral composition (reduction of UV light) or to a change in chemical properties of the cue in humic waters
Studies of the decays D^0 \rightarrow K_S^0K^-\pi^+ and D^0 \rightarrow K_S^0K^+\pi^-
The first measurements of the coherence factor R_{K_S^0K\pi} and the average
strong--phase difference \delta^{K_S^0K\pi} in D^0 \to K_S^0 K^\mp\pi^\pm
decays are reported. These parameters can be used to improve the determination
of the unitary triangle angle \gamma\ in B^- \rightarrow
decays, where is either a D^0 or a D^0-bar meson decaying to
the same final state, and also in studies of charm mixing. The measurements of
the coherence factor and strong-phase difference are made using
quantum-correlated, fully-reconstructed D^0D^0-bar pairs produced in e^+e^-
collisions at the \psi(3770) resonance. The measured values are R_{K_S^0K\pi} =
0.70 \pm 0.08 and \delta^{K_S^0K\pi} = (0.1 \pm 15.7) for an
unrestricted kinematic region and R_{K*K} = 0.94 \pm 0.12 and \delta^{K*K} =
(-16.6 \pm 18.4) for a region where the combined K_S^0 \pi^\pm
invariant mass is within 100 MeV/c^2 of the K^{*}(892)^\pm mass. These results
indicate a significant level of coherence in the decay. In addition, isobar
models are presented for the two decays, which show the dominance of the
K^*(892)^\pm resonance. The branching ratio {B}(D^0 \rightarrow
K_S^0K^+\pi^-)/{B}(D^0 \rightarrow K_S^0K^-\pi^+) is determined to be 0.592 \pm
0.044 (stat.) \pm 0.018 (syst.), which is more precise than previous
measurements.Comment: 38 pages. Version 3 updated to include the erratum information.
Errors corrected in Eqs (25), (26), 28). Fit results updated accordingly, and
external inputs updated to latest best known values. Typo corrected in Eq(3)-
no other consequence
Updated Measurement of the Strong Phase in D0 --> K+pi- Decay Using Quantum Correlations in e+e- --> D0 D0bar at CLEO
We analyze a sample of 3 million quantum-correlated D0 D0bar pairs from 818
pb^-1 of e+e- collision data collected with the CLEO-c detector at E_cm = 3.77
GeV, to give an updated measurement of \cos\delta and a first determination of
\sin\delta, where \delta is the relative strong phase between doubly
Cabibbo-suppressed D0 --> K+pi- and Cabibbo-favored D0bar --> K+pi- decay
amplitudes. With no inputs from other experiments, we find \cos\delta = 0.81
+0.22+0.07 -0.18-0.05, \sin\delta = -0.01 +- 0.41 +- 0.04, and |\delta| = 10
+28+13 -53-0 degrees. By including external measurements of mixing parameters,
we find alternative values of \cos\delta = 1.15 +0.19+0.00 -0.17-0.08,
\sin\delta = 0.56 +0.32+0.21 -0.31-0.20, and \delta = (18 +11-17) degrees. Our
results can be used to improve the world average uncertainty on the mixing
parameter y by approximately 10%.Comment: Minor revisions, version accepted by PR
Higher-order multipole amplitudes in charmonium radiative transitions
Using 24 million decays in CLEO-c, we have searched
for higher multipole admixtures in electric-dipole-dominated radiative
transitions in charmonia. We find good agreement between our data and
theoretical predictions for magnetic quadrupole (M2) amplitudes in the
transitions and ,
in striking contrast to some previous measurements. Let and
denote the normalized M2 amplitudes in the respective aforementioned decays,
where the superscript refers to the angular momentum of the . By
performing unbinned maximum likelihood fits to full five-parameter angular
distributions, we determine the ratios and , where
the theoretical predictions are independent of the charmed quark magnetic
moment and are and .Comment: 32 pages, 7 figures, acceptance updat
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