N′-(2-Methoxy­benzyl­idene)-2-nitro­benzo­hydrazide

The title compound, C15H13N3O4, was synthesized by the reaction of equimolar quanti­ties of 2-methoxy­benzaldehyde and 2-nitro­benzohydrazide in methanol. The dihedral angle between the two substituted benzene rings is 68.3 (2)°. In the crystal structure, inversion dimers linked by pairs of N—H⋯O hydrogen bonds occur

Resilient Moduli of Typical Missouri Soils and Unbound Granular Base Materials

The objective of this project is to accurately determine the resilient moduli for common Missouri subgrade soils and unbound granular base materials in accordance with the AASHTO T 307 test method. The test results included moduli data from 27 common subgrade soils out of the 99 Missouri soil associations and from 5 unbound granular bases. These materials were tested at their optimum water content and at an elevated water content, which would normally occur as a worse case scenario during the life of a pavement. The five unbound granular base materials were tested at two different gradations (high and low side of the Type 5 specification limits) as well as the aforementioned two water contents. Data are provided in the technical report format with all applicable tables and graphs. With the Missouri Department of Transportation (MoDOT) beginning to implement the new Mechanistic-Empirical (M-E) Design Guide for New and Rehabilitated Pavements, the project has accomplished determination of resilient modulus of subgrade soils and unbound granular bases materials used by MoDOT in its flexible pavements. The results of this project allow MoDOT pavement engineers to calibrate the design guide according to Missouri\u27s conditions and materials

Helicity at Photospheric and Chromospheric Heights

In the solar atmosphere the twist parameter $\alpha$ has the same sign as magnetic helicity. It has been observed using photospheric vector magnetograms that negative/positive helicity is dominant in the northern/southern hemisphere of the Sun. Chromospheric features show dextral/sinistral dominance in the northern/southern hemisphere and sigmoids observed in X-rays also have a dominant sense of reverse-S/forward-S in the northern/southern hemisphere. It is of interest whether individual features have one-to-one correspondence in terms of helicity at different atmospheric heights. We use UBF \Halpha images from the Dunn Solar Telescope (DST) and other \Halpha data from Udaipur Solar Observatory and Big Bear Solar Observatory. Near-simultaneous vector magnetograms from the DST are used to establish one-to-one correspondence of helicity at photospheric and chromospheric heights. We plan to extend this investigation with more data including coronal intensities.Comment: 5 pages, 1 figure, 1 table To appear in "Magnetic Coupling between the Interior and the Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200

A CDCL-style calculus for solving non-linear constraints

In this paper we propose a novel approach for checking satisfiability of non-linear constraints over the reals, called ksmt. The procedure is based on conflict resolution in CDCL style calculus, using a composition of symbolical and numerical methods. To deal with the non-linear components in case of conflicts we use numerically constructed restricted linearisations. This approach covers a large number of computable non-linear real functions such as polynomials, rational or trigonometrical functions and beyond. A prototypical implementation has been evaluated on several non-linear SMT-LIB examples and the results have been compared with state-of-the-art SMT solvers.Comment: 17 pages, 3 figures; accepted at FroCoS 2019; software available at <http://informatik.uni-trier.de/~brausse/ksmt/

Speaker recognition with hybrid features from a deep belief network

Learning representation from audio data has shown advantages over the handcrafted features such as mel-frequency cepstral coefficients (MFCCs) in many audio applications. In most of the representation learning approaches, the connectionist systems have been used to learn and extract latent features from the fixed length data. In this paper, we propose an approach to combine the learned features and the MFCC features for speaker recognition task, which can be applied to audio scripts of different lengths. In particular, we study the use of features from different levels of deep belief network for quantizing the audio data into vectors of audio word counts. These vectors represent the audio scripts of different lengths that make them easier to train a classifier. We show in the experiment that the audio word count vectors generated from mixture of DBN features at different layers give better performance than the MFCC features. We also can achieve further improvement by combining the audio word count vector and the MFCC features

Protocol for a systematic review and thematic synthesis of patient experiences of central venous access devices in anti-cancer treatment

Background: Three types of central venous access devices (CVADs)—peripherally inserted central catheters (PICCs), skin-tunnelled central catheters (Hickman-type devices), and implantable chest wall Ports (Ports)—are routinely used in the intravenous administration of anti-cancer treatment. These devices avoid the need for peripheral cannulation and allow for home delivery of treatment. Assessments of these devices have tended to focus on medical and economic factors, but there is increased interest in the importance of patient experiences and perspectives in this area. The aim of this systematic review is to synthesise existing research regarding patient experiences of these CVADs to help clinicians guide, prepare, and support patients receiving CVADs for the administration of anti-cancer treatment. Method: A systematic search of MEDLINE, Embase, and CINAHL research databases will be carried out along with a supplementary reference list search. This review will include quantitative, qualitative, and mixed methods studies published in peer-review journals, reporting some aspect(s) of patient experiences or perspectives regarding the use of PICC, Hickman, or Port CVADs for the administration of anti-cancer drugs. The methodological quality and risk of bias of included papers will be assessed using the Mixed Methods Appraisal Tool (MMAT). Relevant outcome data will be extracted from included studies and analysed using a thematic synthesis approach. Discussion: The results section of the review will comprise thematic synthesis of quantitative studies, thematic synthesis of qualitative studies, and the aggregation of the two. Results will aim to offer an account of current understandings of patient experiences and perspective regarding PICC, Hickman-type, and Port devices in the context of anti-cancer treatment. Confidence in cumulative evidence will be assessed using the Confidence in the Evidence from Reviews of Qualitative research (CERQual) approach

Factors influencing the approaches to studying of preclinical and clinical students and postgraduate trainees

<p>Abstract</p> <p>Background</p> <p>Students can be classified into three categories depending on their approaches to studying; namely, deep approach (DA), strategic approach (SA) and surface apathetic or superficial approach (SAA). The aim of this study was to identify factors affecting the approaches to studying among Sri Lankan medical undergraduates and post graduate trainees and to analyze the change in the pattern of study skills with time and experience.</p> <p>Method</p> <p>Pre-clinical and clinical students of the Faculty of Medicine, University of Colombo and postgraduate trainees in Surgery at the National Hospital of Sri Lanka were invited to complete the Approaches and Study Skills Inventory for Students (ASSIST) questionnaire.</p> <p>Results</p> <p>A total of 187 pre clinical (M: F = 96:91), 124 clinical (M: F = 61:63) and 53 post graduate trainees (M: F = 50:3) participated in the study. Approaches of male and female students were similar. SA was significantly affected by age among the preclinical students (p = 0.01), but not in other groups. Among pre-clinical students, males preferred a teacher who supported understanding (p = 0.04) but females preferred a passive transmission of information (p < 0.001). This, too, was not visible among other groups. A linear regression performed on group (batch), gender, island rank at GCE Advance Level (AL) examination, self appraisal score and the preference scores of type of teacher only managed to explain 35% or less of variance observed for each approach in individual groups.</p> <p>Conclusion</p> <p>Different factors affect the approach to studying in different groups but these explain only a small fraction of the variance observed.</p

N-Cyclo­propyl-N-[2-(2,4-difluoro­phen­yl)-2-hy­droxy-1-(1H-1,2,4-triazol-1-yl)prop­yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra­hydro­pyrimidin-1-yl)acetamide dichloro­methane 0.62-solvate

In the title compound, C21H22F2N6O4·0.62CH2Cl2, the difluoro-substituted benzene ring forms dihedral angles of 54.6 (3)° with the mean plane of the thymine ring and 50.9 (2)° with the triazole ring. The dihedral angle between the thymine and triazole rings is 7.4 (3)°. In the crystal, inter­molecular N—H⋯N and O—H⋯O hydrogen bonds link the main mol­ecules into chains along [10]. The CH2Cl2 solvent mol­ecule was refined as partial occupancy over two sets of sites with refined occupancies of 0.308 (9) and 0.310 (8)

Environmental responses of jellyfish polyps as drivers of medusa populations off the coast of Namibia

Jellyfish populations in the southeastern Atlantic off the coast of Namibia have increased subsequent to the decline of small pelagic fisheries at the end of the 1960s, although the environment there has also become warmer and the waters off Walvis Bay have become richer in zooplankton in recent years. Laboratory experiments were conducted with the scyphozoan jellyfish Chrysaora fulgida to investigate the effects of food density (0, 30, 70, 100 or 150 Artemia nauplii 200 ml–1), feeding frequency (once daily or once every third day) and water temperature (12, 16 or 20 °C) on the asexual reproduction, growth and development of polyps. The results of a generalised linear mixed-effects model reveal that all variables impacted asexual reproduction, with greater polyp production attained at higher food concentrations, increased feeding frequencies and increased temperatures. The most common mode of asexual reproduction was by lateral budding. These laboratory results suggest that polyps of C. fulgi a may have proliferated off Namibia in recent times, which would contribute to increased numbers of jellyfish there.DHE