8 research outputs found
Fourier transform-ion cyclotron resonance study of the gas-phase acidities of germane and methylgermane; bond dissociation energy of germane
AbstractAn accurate gas-phase acidity for germane (enthalpy scale, equivalent to the proton affinity of GeHâ3), ÎŽ H°acid(GeH4) = 1502.0 ± 5.1 kJ molâ1, is obtained by constructing a consistent acidity ladder between GeH4 and H2S by using Fourier transform-ion cyclotron resonance spectrometry, and 0 and 298.15 K values for the first bond dissociation energy of GeH4 are proposed: D°0(H3G3-H) = 352 ± 9 kJ molâ1; D°(H3Ge-H) = 358 ± 9 kJ molâ1, respectively. These results are compared with experimental and theoretical data reported in the literature. Methylgermane was found to be a weaker acid than germane by approximately 35 kJ molâ1: ÎŽ H°acid (MeGeH3) = 1536.6 kJ molâ1
Approche pharmacologique dans la myopathie de Duchenne (nécessité d'un pré-requis sur la fonction respiratoire)
MONTPELLIER-BU MĂ©decine UPM (341722108) / SudocMONTPELLIER-BU MĂ©decine (341722104) / SudocSudocFranceF
Vers un accompagnement « inclusif » des adultes handicapé·es dans la formation professionnelle ?
Les politiques dites « inclusives » visent Ă privilĂ©gier lâaccueil des personnes handicapĂ©es dans le milieu ordinaire plutĂŽt quâen Ă©tablissements spĂ©cialisĂ©s. Tout comme dans la formation initiale, cette dynamique se dĂ©veloppe dans la formation professionnelle des adultes en recherche dâemploi. Ce CĂ©req Bref se penche ainsi sur une offre de compensation du handicap, le dispositif Formation AccompagnĂ©e, expĂ©rimentĂ© en Normandie et en cours dâessaimage sur tout le territoire. LâĂ©valuation pointe les enjeux de la prise en compte effective des limitations de capacitĂ©s des stagiaires, et du pĂ©rimĂštre des expertises des professionnel·les chargé·es de les accompagner durant leur parcours de formation
Characteristics and origin of the glass spherules from the Paleocene flood basalt province of western Greenland
International audienc
Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression
Abstract Skeletal muscle satellite cells are quiescent adult resident stem cells that activate, proliferate and differentiate to generate myofibres following injury. They harbour a robust proliferation potential and self-renewing capacity enabling lifelong muscle regeneration. Although several classes of microRNAs were shown to regulate adult myogenesis, systematic examination of stage-specific microRNAs during lineage progression from the quiescent state is lacking. Here we provide a genome-wide assessment of the expression of small RNAs during the quiescence/activation transition and differentiation by RNA-sequencing. We show that the majority of small RNAs present in quiescent, activated and differentiated muscle cells belong to the microRNA class. Furthermore, by comparing expression in distinct cell states, we report a massive and dynamic regulation of microRNAs, both in numbers and amplitude, highlighting their pivotal role in regulation of quiescence, activation and differentiation. We also identify a number of microRNAs with reliable and specific expression in quiescence including several maternally-expressed miRNAs generated at the imprinted Dlk1-Dio3 locus. Unexpectedly, the majority of class-switching miRNAs are associated with the quiescence/activation transition suggesting a poised program that is actively repressed. These data constitute a key resource for functional analyses of miRNAs in skeletal myogenesis, and more broadly, in the regulation of stem cell self-renewal and tissue homeostasis
Poésie et langue : aspects théoriques et didactiques
Cette livraison renoue avec lâhistoire un peu compliquĂ©e de la revue Pratiques et de la poĂ©sie, jadis au cĆur de son projet politique et didactique de rĂ©novation de lâenseignement du français. Mais au fil du temps, les numĂ©ros consacrĂ©s Ă la poĂ©sie, ou, mieux encore, lâintĂ©grant dans ses problĂ©matiques (syntaxe, sĂ©mantique, lexicologie, genre, rĂ©cit, Ă©crit-oral, ponctuation entre autres) Ă©taient devenus rares et de plus en plus pessimistes. Car la poĂ©sie, transgenre, trans-rĂ©gime (linguistique) et peut-ĂȘtre transdisciplinaire, peut opĂ©rer, sur la langue et sur lâenseignement, un triple effet, de stimulation, de loupe et de questionnement. Les poĂštes et les linguistes renouent ici les fils quâon avait laissĂ©s sâeffilocher, malgrĂ© les travaux sur la poĂ©sie de Saussure, rĂ©intĂ©grĂ©s dans une leçon moins structuraliste, et ceux mis au jour plus rĂ©cemment de Benveniste, de Coseriu (sans oublier ceux de Jakobson et Meschonnic) qui nous montrent quâil y a bien une tradition (indo)europĂ©enne et francophone de lien entre poĂ©sie et thĂ©ories de la langue â largement rĂ©assurĂ©e par Humboldt et MallarmĂ© au XIXe siĂšcle â quâil faut faire fructifier, loin dâune thĂ©orie de lâĂ©cart poĂ©tique, qui exclut la poĂ©sie de la langue et de la didactique du français. Les didacticiens de FLM et de FLE (soutenus par les poĂštes), avec leurs manuels, leurs genres dâactivitĂ©s et leurs gestes professionnels, peuvent-ils rester Ă la traine, au moment oĂč la psychologie cognitive, les thĂ©ories de la rĂ©ception littĂ©raire subjective, de la communication empirique et consumĂ©riste et de lâergonomie du travail semblent occuper tout lâespace scientifique et professionnel, et conduire la main des politiques ? Câest au contraire le bon moment oĂč la poĂ©sie, la linguistique et lâĂ©cologie de lâapprentissage doivent sâinviter au dĂ©bat public pour faire en sorte quâimaginaires singuliers, imaginaires collectifs, configurations littĂ©raires et textuelles dâun cĂŽtĂ©, et rĂ©flexivitĂ© raisonnĂ©e sur la langue et les Ćuvres de lâautre Ă©paulent, complĂštent ou contredisent les prĂ©cĂ©dentes dans « Le Grand Combat » de demain â celui de Michaux et de nous tous â de la lutte contre lâĂ©chec scolaire et la marginalisation sociale, et pour lâhumanisation dĂ©mocratique toujours Ă reconstruire. Demain, Ă nouveau, la poĂ©sie pourra rĂ©pondre : prĂ©sente
l-Arginine Decreases Inflammation and Modulates the Nuclear Factor-ÎșB/Matrix Metalloproteinase Cascade in Mdx Muscle Fibers
Duchenne muscular dystrophy (DMD) is a lethal, X-linked disorder associated with dystrophin deficiency that results in chronic inflammation, sarcolemma damage, and severe skeletal muscle degeneration. Recently, the use of l-arginine, the substrate of nitric oxide synthase (nNOS), has been proposed as a pharmacological treatment to attenuate the dystrophic pattern of DMD. However, little is known about signaling events that occur in dystrophic muscle with l-arginine treatment. Considering the implication of inflammation in dystrophic processes, we asked whether l-arginine inhibits inflammatory signaling cascades. We demonstrate that l-arginine decreases inflammation and enhances muscle regeneration in the mdx mouse model. Classic stimulatory signals, such as proinflammatory cytokines interleukin-1ÎČ, interleukin-6, and tumor necrosis factor-α, are significantly decreased in mdx mouse muscle, resulting in lower nuclear factor (NF)-ÎșB levels and activity. NF-ÎșB serves as a pivotal transcription factor with multiple levels of regulation; previous studies have shown perturbation of NF-ÎșB signaling in both mdx and DMD muscle. Moreover, l-arginine decreases the activity of metalloproteinase (MMP)-2 and MMP-9, which are transcriptionally activated by NF-ÎșB. We show that the inhibitory effect of l-arginine on the NF-ÎșB/MMP cascade reduces ÎČ-dystroglycan cleavage and translocates utrophin and nNOS throughout the sarcolemma. Collectively, our results clarify the molecular events by which l-arginine promotes muscle membrane integrity in dystrophic muscle and suggest that NF-ÎșB-related signaling cascades could be potential therapeutic targets for DMD management