Trastornos de la comunicación en el autismo

[Resumen] El autismo es un trastorno generalizado del desarrollo caracterizado, entre otros rasgos, por una falta de interés y/o capacidad para la comunicación y para la interacción social. En este artículo hemos querido dar una visión general de los distintos rasgos que caracterizan el espectro autista, así conceptualizado por la gran variabilidad en la gravedad de sus síntomas. Entre estos, hemos descrito las deficiencias en la interacción social, las respuestas atípicas a los estímulos sensoriales, las deficiencias motoras y conductas atípicas, los trastornos afectivos, el repertorio limitado de actividades e intereses y las deficiencias cognitivas. Nos hemos centrado en los trastornos del lenguaje y en los síndromes principales, para finalmente, proporcionar una visión general de las principales intervenciones encaminadas al desarrollo y mejora de la comunicación en el autism

Portland cement pastes analysed by synchrotron and laboratory X-ray imaging

Portland Cement (PC) is the most used construction material and the derived building materials have very complex hierarchical microstructures. Quantitative characterization of their microstructures is of paramount importance for assessing the performance and durability of the final products. As cement performance is controlled by its phase composition and microstructure, in particular, the pore network plays a critical role in the mechanical properties and durability. The chemical and hydration changes in PC binders affect their performances mainly because of the binding properties of the main component, the so-called C-S-H gel. Here, we analyse porosity in PC pastes using laboratory and synchrotron X-ray micro-tomography with different water to cement mass ratios (w/c) after 28 days of hydration. Monochromatic synchrotron X-ray microtomography is used for reference and the main aim is determining volume percentage of different components with focus on porosity. It will be shown, as expected, that higher amount of water (that increases fluidity of pastes) results in higher porosities at 28 days of hydration. Therefore, in the histogram and tomograms more pores, hydrated materials, and less anhydrous materials would appear with increasing w/c (see Figure 1). The excellent spatial resolution (and slightly better contrast) of synchrotron experiments serve as reference for data analysis. Despite 0.2-0.3 m voxel-sizes in all the used experimental setups (see Figure 2), the laboratory tomograms show some limitations that will be discussed. In this work, a two-steps approach is followed. Firstly, we will report the analysis of the histograms by classifying in the three types of components based on grey-levels: i) pores, ii) hydrated components; and iii) unreacted cement phases. Secondly, segmented pore contribution will be further analyzed and the results from laboratory tomograms will be compared with the reference values derived from synchrotron data.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Relationship between Parenting Styles and Aggressiveness in Adolescents

Abstract Introduction. Physical and verbal aggressive behavior that children and adolescents sho

Occupational therapy and professional identity: narratives of professionals through life history. study protocol

[Abstract] Project title: Occupational therapy and professional identity: narratives of professionals through life history. Study Protocol. Design: Qualitative research, using a socio-critical paradigm and biographical-narrative method where participants were selected through theoretical sampling and snowball sampling strategy. Data collection techniques were life stories, constructed through biograms, self-reports and biographical interviews. Abductive reasoning was used along with structural analysis techniques, narrative analysis, and ATLAS. ti software. Objective: To describe and analyze the occupational construct of the professional identity of occupational therapists in Spain. Specific Objectives: (1) Analyze life events, transitions, and turning points that contribute to the outlining of the life journey of professional identity. (2) Explore the management of professional tasks. (3) Analyze the nature of the knowledge required to carry out the role. (4) Examine in detail the strategies applied to the personal engagement of occupational therapists. Study Population and Total Number of Participants: The study population consisted of professionals who are currently working as occupational therapists in Spain. The number of participants was established when data saturation was reached, with a total of nine informants

Analysis of occupational therapy students’ pedagogical practices for the forging of professional identity and development of professional intelligence: a scoping review

Review[Abstract] Pedagogical practices contribute to enhancing professional intelligence which is an indicator of maturity and development of professional identity. The research guiding question was: What are the pedagogical practices involved in occupational therapy students' professional identity formation? A scoping review using a six-stage methodological framework was used to capture a variety of evidence describing how professional identity has been conceptualised and integrated into the occupational therapy curriculum while noticing a link to professional intelligence. Databases included were: Ovid MEDLINE, CINAHL, PsycINFO, ProQuest ERIC, Scopus, Web of Science, CSIC, Dialnet, PubMed, Pubmed Central, OTDBASE and Scielo. Qualitative content analysis was used to categorise learning outcomes into five components of professional identity that were associated with the pedagogical practices identified in the studies. n = 58 peer-reviewed journal articles were recorded. The articles were classified as intervention studies (n = 31; 53.4%), reviews (n = 12; 20.7%) and theoretical articles (n = 15; 25.9%). To ensure the feasibility of collecting and reporting results, we narrowed the focus to n = 31 intervention studies that provided information on pedagogical practices and learning outcomes on professional identity forging in students. This scoping review illustrates the variety of contexts in which students learn, the multiple dimensions of identity establishment, and the variety of pedagogical practices. These findings can be used to adapt and design focused formative curricula that support the development of professional identity

Belite calcium sulfoaluminate cement early hydration: citric acid sensitivity.

Three buckets, corresponding to three selected samples, of the same type of belite calcium sulfoaluminate (BCSA) cements have been studied. These cements show very similar elemental and mineralogical compositions, and textural properties. Mortars, for mechanical strength characterisation at 3 and 24 hours, were prepared by two different methodologies: i) with w/c of 0.40 without citric acid and ii) with w/c=0.40 and adding 0.375 wt% by weight of cement (bwc) of citric acid used as a retarder. On the one hand, the mechanical strengths, at 24 hours, obtained by the three mortars prepared by both methodologies are almost coincident, 61(5) MPa without citric acid and 61(4) MPa for the mortars prepared with citric acid. On the other hand, the early mechanical strengths at 3 hours for the mortars prepared without citric acid are also almost coincident among the three cements, i.e. ~49(3) MPa. However, when the citric acid is added, the mechanical strengths at 3 hours are quite different among the three buckets, i.e. 34(1), 42(1) and 48(1) MPa, respectively. The main aim of this study is to understand the reasons causing the different early mechanical strengths. First of all, a full characterization of the three cements has been performed: textural properties, elemental composition by X-Ray Fluorescence (XRF) and mineralogical composition, including the amorphous content, by Laboratory X-Ray Powder Diffraction (LXRPD) combined with the Rietveld method. Moreover, the soluble sulphate contents within the first minutes of hydration are being determined. An isothermal calorimetry study at 20ºC for pastes without and with different amounts of citric acid will be presented as well as in situ X-Ray powder diffraction data analysis. The results will be discussed to give a picture of the early hydration behaviour of these BCSA cements.CTS cement corporation, CSA research Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Efectos del entrenamiento interválico de alta intensidad durante el periodo transitorio en jugadores de fútbol sub-19

Actualmente existe un creciente interés por la aplicación del entrenamiento interválico de alta intensidad (HIIT) en fútbol (Buchheit et al. 2013). La eficacia mostrada por esta metodología de entrenamiento para mejorar las variables del rendimiento ha provocado una mayor aplicación en deportes colectivos (Iaia et al. 2009). Sin embargo, es escasa la literatura científica acerca de su impacto en fútbol. Por ello, el objetivo del trabajo es comparar los efectos sobre el rendimiento del HIIT versus entrenamiento tradicional durante el periodo transitorio invernal en jugadores de fútbol sub-19

Many-particle Brownian and Langevin Dynamics Simulations with the Brownmove package

<p>Abstract</p> <p>Background</p> <p>Brownian Dynamics (BD) is a coarse-grained implicit-solvent simulation method that is routinely used to investigate binary protein association dynamics, but due to its efficiency in handling large simulation volumes and particle numbers it is well suited to also describe many-protein scenarios as they often occur in biological cells.</p> <p>Results</p> <p>Here we introduce our "brownmove" simulation package which was designed to handle many-particle problems with varying particle numbers and allows for a very flexible definition of rigid and flexible protein and polymer models. Both a Brownian and a Langevin dynamics (LD) propagation scheme can be used and hydrodynamic interactions are treated efficiently with our recently introduced TEA-HI ansatz [Geyer, Winter, JCP 130 (2009) 114905]. With simulations of constrained polymers and flexible models of spherical proteins we demonstrate that it is crucial to include hydrodynamics when multi-bead models are used in BD or LD simulations. Only then both the translational and the rotational diffusion coefficients and the timescales of the internal dynamics can be reproduced correctly. In the third example project we show how constant density boundary conditions [Geyer et al, JCP 120 (2004) 4573] can be used to set up a non-equilibrium simulation of diffusional transport across an array of fixed obstacles. Finally, we demonstrate how the agglomeration dynamics of multiple particles with attractive patches can be analysed conveniently with the help of a dynamic interaction network.</p> <p>Conclusions</p> <p>Combining BD and LD propagation, fast hydrodynamics, a flexible protein model, and interfaces for "open" simulation settings, our freely available "brownmove" simulation package constitutes a new platform for coarse-grained many-particle simulations of biologically relevant diffusion and transport processes.</p

Effect of alkanolamines in kaolinitic calcined clays pozzolanic reactivity.

Five kaolinitic clays with different amounts of kaolinite, ranging between ~70 wt% and ~30 wt%, have been studied to unravel the possible activation effect of alkanolamines on the aluminate fraction of calcined clays. This is of interest for enhancing the reactivity of LC3 binders. These clays were calcinated at 860ºC for 4 h and ground to particle sizes of DV,50 ~10 μm. Three alkanolamines were selected: triisopropanolamine (TIPA), triethanolamine (TEA) and methyldiethanolamine (MDEOA), added in two dosages, 0.025 and 0.050 wt% (by weight of calcined clay, bwcc). The role of alkanolamines as activators in calcined clays was assessed following the ASTM c1897 standard bases on R3-tests. Concretely, first by measuring the heat evolved due to the pozzolanic reaction of the calcined clay and Ca(OH)2 (i.e. R3 mixture) by isothermal calorimetry at 40ºC during 7 days, and second, the bounded water by measuring the weight loss of R3 mixture after heating them at 350ºC.This study concludes that there is no significant activation of the pozzolanic activity of kaolinitic calcined clays just by adding alkanolamines. However, a mild activation was observed, i.e., higher heat evolved up to 7 days, by adding 0.05 wt% bwcc of TIPA, TEA and MDEOA to a high kaolinite content disordered metakaolin with high specific surface area calcined clay.PID2020-114650RB-I00 CTS cement corporation Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Inflammasome in als skeletal muscle: Nlrp3 as a potential biomarker

Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders, we hypothesized that levels of inflammasome components could help in diagnosis or prognosis of amyotrophic lateral sclerosis (ALS). Gene and protein expression was assayed by RT-PCR and Western blot. Spearman’s correlation coefficient was used to determine the linear correlation of transcriptional expression levels with longevity throughout disease progression in mice models. Kaplan-Meier analysis was performed to evaluate MCC950 effects (NLRP3 inhibitor) on lifespan of SOD1G93A mice. The results showed significant alterations in NLRP3 inflammasome gene and protein levels in the skeletal muscle of SOD1G93A mice. Spearman’s correlation coefficient revealed a positive association between Nlrp3 transcriptional levels in skeletal muscle and longevity of SOD1G93A mice (r = 0.506; p = 0.027). Accordingly, NLRP3 inactivation with MCC950 decreased the lifespan of mice. Furthermore, NLRP3 mRNA levels were significantly elevated in the blood of ALS patients compared to healthy controls (p = 0.03). In conclusion, NLRP3 could be involved in skeletal muscle pathogenesis of ALS, either through inflammasome or independently, and may play a dual role during disease progression. NLRP3 gene expression levels could be used as a biomarker to improve diagnosis and prognosis in skeletal muscle from animal models and also to support diagnosis in clinical practice with the blood of ALS patients