Relationship between Quarry Activity and Municipal Spatial Planning: A Possible Mediation for the Case of Sardinia, Italy

Despite its economic importance, quarrying activity for the production of natural aggregates (sand, gravel, and crushed stone) can result in overexploitation of the natural environment. This paper investigates the current state of natural and recycled aggregates in Sardinia Italy and how to limit the production of natural aggregates (NA) and increase the use of recycled aggregates (RA). The municipalities of Cagliari, Sant’Antioco and Tortolì of Sardinia, Italy, were chosen as case studies because they fall within a particular territorial context. Owing to its geographic condition, the island of Sardinia must produce its own raw materials. The results of this research show how the combined use of NA and RA can help meet local and regional demand for aggregates. This proposal is derived from a needs assessment of NA based on urban masterplans for each municipality. Possible strategies for limiting the consumption of NA, as well as the use of RA, are also described

Urban redevelopment and energy saving. The case of the incentives in Italy, between risks and opportunities

Building construction consumes energy and materials. Even if the scientific community has developed two main voluntary protocols of building construction evaluation (BREAM and LEED), the authors argue that one of the main factors that could be incisive for a better environmental sustainability is to stimulate all possible initiatives, including the reuse of recyclable building materials, that currently, is a modest application. Based on this, the paper is organized in two parts. The first is an analysis of the Italian situation with regard to urban redevelopment and energy saving, considering the number of intiatives and costs handed out for each region. The second evaluates and proposes new insights on the basis of the obtained results

May a standard VOF numerical simulation adequately complete spillway laboratory measurements in an operational context? The case of Sa Stria Dam

The present work aims to assess whether a standard numerical simulation (RANS-VOF model with k e closure) can adequately model experimental measurements obtained in a dam physical model. The investigation is carried out on the Sa Stria Dam, a roller compacted concrete gravity dam currently under construction in Southern Sardinia (Italy). The original project, for which a physical model was simulated, included a downstream secondary dam. However, due to both economic and technical reasons, the secondary dam may not be built. Hence, it is important to assess the flood discharge routing and energy dissipation in the modified plan. Numerical validation is performed adopting the same laboratory configuration, in presence of the downstream dam, and results show a good agreement with mean experimental variables (i.e., pressure, water level). An alternative configuration without the downstream dam is here numerically tested to understand the conditions of flood discharge and assess whether its results can give relevant information for the design of mitigation measures. The topic is of interest also from a more general perspective. Indeed, the feasibility to integrate numerical models with existing laboratory measurements can be very useful not only for new constructions but also for existing dams, which may need either maintenance or upgrading works, such as in case of flood discharge increment

Oral microbiota, health, and cancer: the dual face of the same coin in the field of the host-microbe interactome

In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and microbes. On the other hand, molecular and cellular diversity and their involvement in health responses to changing host conditions have only recently been understood, through the development of brand-new laboratory tools based on ‘omics approaches. The continuous insertion of already conceptualized, new experimental large datasets and raw data onto bibliographic platforms means that they are now accessible for subsequent elaboration by other researchers. This aspect has allowed the creation of an interactive mesh of proteins, genes, and small molecules, usually called, interactome or interactomics

A gyro-elastic device for cloaking of elastic waves in micro-structured materials

The design of a structured gyro-elastic system capable of being used as a cloaking device for a discrete medium is discussed. The efficiency of the gyro-elastic cloak, composed of springs connecting periodically placed masses, attached to gyroscopic spinners, is examined in the transient regime. An important effect encountered shows that the speed of the reconstructed field can be altered by tuning the gyroscopes

Rare jaw bone tumor: The importance of multidisciplinary management and minimally invasive treatment

Objective: The aim of this study was to present a mini review of oral Cementoblastoma and to report a particular case of this tumor. The Cementoblastoma is a rare benign lesion that represents less than 1-6% of all odontogenic tumors. Cementoblastoma, in the current WHO classification of odontogenic tumors, falls under the category of mesenchymal tumors (WHO 2017) and it is characterized by the proliferation of cementum-like tissue and, in all cases, tends to be associated with an erupting permanent tooth, most often the first molar. Case Presentation: A 15-year-old female presented a great Cementoblastoma with cortical expansion that affected the left mandibular body, extending from the canine to the first premolar (size 28x24 mm) and involving the mandibular canal. Surgery was performed under general anesthesia with total excision of the lesion, which was then sent for histological analysis. Due to the high risk of nerve injuries and the extreme fragility of the remaining bone after surgery, which required plates and intermaxillary blockage, the surgical site was regenerated with an iliac crest graft together with autologous and synthetic bone. Results: For the mini-review, 107 articles were found, but only 26 were selected. The patient was monitored for 12 months after surgery; a perfect healing was reported without complications, and she showed no signs of recurrence. Conclusions: This case report emphasizes the usefulness of clinical choices in a rare case of cementoblastoma of great size in a very young patient. In this condition, finding the most effective eradicative and reconstructive treatment, following the last published protocols, could achieve optimal clinical and psychological patient outcomes

Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat.

Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology and techniques to monitor population activity in transgenic rats in vivo, we investigated the contribution of A13-DA neurons in reward and movement-related actions. Our work demonstrates a role for A13-DA neurons in grasping and handling of objects but not reward. A13-DA neurons responded strongly when animals grab and manipulate food items, whereas their inactivation or degeneration prevented animals from successfully doing so-a deficit partially attributed to a reduction in grip strength. By contrast, there was no relation between A13-DA activity and food-seeking behavior when animals were tested on a reward-based task that did not include a reaching/grasping response. Motivation for food was unaffected, as goal-directed behavior for food items was in general intact following A13 neuronal inactivation/degeneration. An anatomical investigation confirmed that A13-DA neurons project to the superior colliculus (SC) and also demonstrated a novel A13-DA projection to the reticular formation (RF). These results establish a functional role for A13-DA neurons in prehensile actions that are uncoupled from the motivational factors that contribute to the initiation of forelimb movements and help position A13-DA circuits into the functional framework regarding centrally located DA populations and their ability to coordinate movement

Interfacial waveforms in chiral lattices with gyroscopic spinners

We demonstrate a new method of achieving topologically protected states in an elastic hexagonal system of trusses by attaching gyroscopic spinners, which bring chirality to the system. Dispersive features of this medium are investigated in detail, and it is shown that one can manipulate the locations of stop-bands and Dirac points by tuning the parameters of the spinners. We show that, in the proximity of such points, uni-directional interfacial waveforms can be created in an inhomogeneous lattice and the direction of such waveforms can be controlled. The effect of inserting additional soft internal links into the system, which is thus transformed into a heterogeneous triangular lattice, is also investigated, as the hexagonal lattice represents the limit case of the heterogeneous triangular lattice with soft links. This work introduces a new perspective in the design of periodic media possessing non-trivial topological features

Design of a chiral elastic structure supporting interfacial waveforms

An infinite heterogeneous elastic triangular lattice connected to a non-uniform array of gyroscopic spinners is considered. An algorithm is described for generating interfacial waves that propagate along the boundaries of subdomains containing inhomogeneities in the spinner array. The interfacial waveforms have preferential directions that can be controlled through adjusting the frequency of excitation or the arrangement of the spinners