148 research outputs found
Cereal Genome Evolution: Grasses, line up and form a circle
AbstractThe genomes of six major grass species can be aligned by dissecting the individual chromosomes into segments and rearranging these linkage blocks into highly similar structures
Coherence Time Effects on J/psi Production and Suppression in Relativistic Heavy Ion Collisions
Using a coherence time extracted from high precision proton-nucleus Drell-Yan
measurements and a nuclear absorption cross section extracted from pA
charmonium production experiments, we study J/psi production and absorption in
nucleus-nucleus collisions. We find that coherence time effects are large
enough to affect the measured J/psi-to-Drell-Yan ratio. The S+U data at 200A
GeV/c measured by NA38 are reproduced quantitatively without the introduction
of any new parameters. However, when compared with recent NA50 measurements for
Pb+Pb at 158A GeV/c, the data is not reproduced in trend or in magnitude.Comment: 8 pages, 2 figure
High-p_T pion and kaon production in relativistic nuclear collisions
High-p_T pion and kaon production is studied in relativistic proton-proton,
proton-nucleus, and nucleus-nucleus collisions in a wide energy range. Cross
sections are calculated based on perturbative QCD, augmented by a
phenomenological transverse momentum distribution of partons (``intrinsic
k_T''). An energy dependent width of the transverse momentum distribution is
extracted from pion and charged hadron production data in
proton-proton/proton-antiproton collisions. Effects of multiscattering and
shadowing in the strongly interacting medium are taken into account.
Enhancement of the transverse momentum width is introduced and parameterized to
explain the Cronin effect. In collisions between heavy nuclei, the model
over-predicts central pion production cross sections (more significantly at
higher energies), hinting at the presence of jet quenching. Predictions are
made for proton-nucleus and nucleus-nucleus collisions at RHIC energies.Comment: 26 pages in Latex, 19 EPS figure
Differential directed flow in Au+Au collisions
We present experimental data on directed flow in semi-central Au+Au
collisions at incident energies from 90 to 400 A MeV. For the first time for
this energy domain, the data are presented in a transverse momentum
differential way. We study the first order Fourier coefficient v1 for different
particle species and establish a gradual change of its patterns as a function
of incident energy and for different regions in rapidity.Comment: 5 pages, Latex, 5 eps figures, accepted for publication in Phys. Rev.
C (Rapid Communications). Data files available at
http://www-linux.gsi.de/~andronic/fopi/v1.htm
Directed flow in Au+Au, Xe+CsI and Ni+Ni collisions and the nuclear equation of state
We present new experimental data on directed flow in collisions of Au+Au,
Xe+CsI and Ni+Ni at incident energies from 90 to 400A MeV. We study the
centrality and system dependence of integral and differential directed flow for
particles selected according to charge. All the features of the experimental
data are compared with Isospin Quantum Molecular Dynamics (IQMD) model
calculations in an attempt to extract information about the nuclear matter
equation of state (EoS). We show that the combination of rapidity and
transverse momentum analysis of directed flow allow to disentangle various
parametrizations in the model. At 400A MeV, a soft EoS with momentum dependent
interactions is best suited to explain the experimental data in Au+Au and
Xe+CsI, but in case of Ni+Ni the model underpredicts flow for any EoS. At 90A
MeV incident beam energy, none of the IQMD parametrizations studied here is
able to consistently explain the experimental data.Comment: RevTeX, 20 pages, 30 eps figures, accepted for publication in Phys.
Rev. C. Data files available at http://www.gsi.de/~fopiwww/pub
Impact of a Prior Cancer Diagnosis on Quality of Care and Survival Following Acute Myocardial Infarction: Retrospective Population-Based Cohort Study in England
BACKGROUND: An increasing proportion of patients with cancer experience acute myocardial infarction (AMI). We investigated
differences in quality of AMI care and survival between patients with and without previous cancer diagnoses.
METHODS: A retrospective cohort study using Virtual Cardio-Oncology Research Initiative data. Patients aged 40+ years
hospitalized in England with AMI between January 2010 and March 2018 were assessed, ascertaining previous cancers
diagnosed within 15 years. Multivariable regression was used to assess effects of cancer diagnosis, time, stage, and site on
international quality indicators and mortality.
RESULTS: Of 512388 patients with AMI (mean age, 69.3 years; 33.5% women), 42187 (8.2%) had previous cancers.
Patients with cancer had significantly lower use of ACE (angiotensin-converting enzyme) inhibitors/angiotensin receptor
blockers (mean percentage point decrease [mppd], 2.6% [95% CI, 1.8–3.4]) and lower overall composite care (mppd,
1.2% [95% CI, 0.9–1.6]). Poorer quality indicator attainment was observed in patients with cancer diagnosed in the last
year (mppd, 1.4% [95% CI, 1.8–1.0]), with later stage disease (mppd, 2.5% [95% CI, 3.3–1.4]), and with lung cancer
(mppd, 2.2% [95% CI, 3.0–1.3]). Twelve-month all-cause survival was 90.5% in noncancer controls and 86.3% in adjusted
counterfactual controls. Differences in post-AMI survival were driven by cancer-related deaths. Modeling improving quality
indicator attainment to noncancer patient levels showed modest 12-month survival benefits (lung cancer, 0.6%; other
cancers, 0.3%).
CONCLUSIONS: Measures of quality of AMI care are poorer in patients with cancer, with lower use of secondary prevention
medications. Findings are primarily driven by differences in age and comorbidities between cancer and noncancer populations
and attenuated after adjustment. The largest impact was observed in recent cancer diagnoses (<1 year) and lung cancer.
Further investigation will determine whether differences reflect appropriate management according to cancer prognosis or
whether opportunities to improve AMI outcomes in patients with cancer exist
Toxicidade do alumínio e efeito do ácido giberélico em linhas quase isogênicas de trigo com o caráter permanência verde e maturação sincronizada
Meiotic behavior of interspecific hybrids between artificially tetraploidized sexual Brachiaria ruziziensis and tetraploid apomictic B. brizantha (Poaceae)
Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease after Reduced-Intensity Conditioning Allogeneic Transplantation
The combination of a calcineurin inhibitor (CNI) such as tacrolimus (TAC) or cyclosporine (CYSP) with methotrexate (MTX) or with mycophenolate mofetil (MMF) has been commonly used for graft-versus-host disease (GVHD) prophylaxis after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT), but there are limited data comparing efficacy of the 2 regimens. We evaluated 1564 adult patients who underwent RIC alloHCT for acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and myelodysplastic syndrome (MDS) from 2000 to 2013 using HLA-identical sibling (matched related donor [MRD]) or unrelated donor (URD) peripheral blood graft and received CYSP or TAC with MTX or MMF for GVHD prophylaxis. Primary outcomes of the study were acute and chronic GVHD and overall survival (OS). The study divided the patient population into 4 cohorts based on regimen: MMF-TAC, MMF-CYSP, MTX-TAC, and MTX-CYSP. In the URD group, MMF-CYSP was associated with increased risk of grade II to IV acute GVHD (relative risk [RR], 1.78; P <.001) and grade III to IV acute GVHD (RR, 1.93; P =.006) compared with MTX-TAC. In the URD group, use of MMF-TAC (versus MTX-TAC) lead to higher nonrelapse mortality. (hazard ratio, 1.48; P =.008). In either group, no there was no difference in chronic GVHD, disease-free survival, and OS among the GVHD prophylaxis regimens. For RIC alloHCT using MRD, there are no differences in outcomes based on GVHD prophylaxis. However, with URD RIC alloHCT, MMF-CYSP was inferior to MTX-based regimens for acute GVHD prevention, but all the regimens were equivalent in terms of chronic GVHD and OS. Prospective studies, targeting URD recipients are needed to confirm these results
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