Diagnosis and treatment of missing upper lateral incisors part 2

These two articles aim to outline the assessment and explain the treatment options for those patients who present with missing upper lateral incisors. In Part 1, emphasis is placed on the diagnosis and need for a combined orthodontic-restorative approach to provide optimal patient care. Clinical Relevance: The management of patients with absence of one or both lateral incisors can be an aesthetic and functional challenge. Frequently, a number of different factors need to be considered in order to achieve the best end result. We suggest that a combined orthodontic-restorative approach be considered at the start of the planning process, in order to consider all treatment possibilities. </jats:p

Analysis of width/height ratio and gingival zenith in patients with bilateral agenesis of maxillary lateral incisor

OBJECTIVE: The purpose of this study was to evaluate the width/length ratio and the gingival zenith (GZ), by means of dental casts and digital caliper, in patients with missing maxillary lateral incisors after treatment. METHODS: The sample was composed of 52 subjects divided into 3 groups: BRG (n = 18), patients with bilateral agenesis treated with tooth re-contouring; BIG (n = 10) patients with agenesis treated with implants and CG (n = 24), control group. The data were analyzed using Shapiro-Wilk, Spearman correlation, Wilcoxon, Kruskal-Wallis, t test and ANOVA tests (p < 0.05). RESULTS: For the width/length ratio of the lateral incisors, BIG presented the lowest mean values (0.72 right and left), when compared with other groups. However, comparison between groups presented statistically significant differences for the right lateral incisor (BIG x CG) and for the canine (BRG x CG). GZ data evaluation showed the greatest difference for BRG (0.5 right and 0.48 left). BIG (0.95 right and 0.98 left) and CG (0.98 right and 0.8 left) presented more similar values, nevertheless, without statistical difference (p > 0.05). GZ data for the right and left sides of the smile were not considered statistically different. CONCLUSION: Although no statistical difference was found in the comparison between the groups, analysis of the descriptive values showed that group BIG showed the greatest difference in values with regard to width/length ratio. Regarding gingival zenith, BRG showed the greatest difference.<br>OBJETIVO: o propósito desse estudo foi analisar, por meio de modelos de estudo e paquímetro digital, a proporção largura/altura e o zênite gengival (ZG) em pacientes com agenesia bilateral do incisivo lateral superior após o tratamento. MÉTODOS: a amostra consistiu de 52 voluntários divididos em 3 grupos: GBR (n=18), pacientes com agenesia bilateral tratados com reanatomizações dentárias; GBI (n=10), pacientes com agenesia bilateral tratados com implantes; e GC (n=24), grupo controle. Os dados foram avaliados por meio dos testes de Shapiro-Wilk, Wilcoxon, Kruskal-Wallis, teste t, ANOVA (p<0,05) e correlação de Spearman. RESULTADOS: para a proporção largura/altura dos incisivos laterais, o GBI apresentou menores valores (0,72 direito e esquerdo), quando comparado aos demais. Porém, a comparação intergrupos revelou diferenças estatisticamente significativas para o incisivo lateral direito (GBI x GC) e para o canino (GBR x GC). A avaliação das medianas obtidas para o ZG demonstrou que o GBR foi o mais destoante (0,5 direito e 0,48 esquerdo), e que o GBI (0,95 direito e 0,98 esquerdo) e o GC (0,98 direito e 0,8 esquerdo) apresentaram valores semelhantes, sem diferença estatisticamente significativa (p>0,05). Os valores obtidos para os lados direito e esquerdo foram considerados iguais dentro de cada grupo. CONCLUSÃO: embora não tenham sido encontradas diferenças estatísticas na comparação entre os grupos, pela análise descritiva dos dados, o GBI foi o grupo que apresentou as medidas mais destoantes dos demais em relação à proporção largura/altura, sendo que, para o zênite gengival, a maior diferença observada foi no GBR

A multidisciplinary approach for the management of hypodontia: case report

Hypodontia is the congenital absence of one or more teeth and may affect permanent teeth. Several options are indicated to treat hypodontia, including the maintenance of primary teeth or space redistribution for restorative treatment with partial adhesive bridges, tooth transplantation, and implants. However, a multidisciplinary approach is the most important requirement for the ideal treatment of hypodontia. This paper describes a multidisciplinary treatment plan for congenitally missing permanent mandibular second premolars involving orthodontics, implantology and prosthodontic specialties

Workflow description to dynamically model beta-arrestin signaling networks

International audienceDynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and confrontation with kinetic biological data. Despite its standardization, dynamic modeling of signaling networks still requires successive technical steps that need to be carefully performed. Here, we detail these steps by going through the mathematical and statistical framework. We explain how it can be applied to the understanding of β-arrestin-dependent signaling networks. We illustrate our methodology through the modeling of β-arrestin recruitment kinetics at the Follicle Stimulating Hormone (FSH) receptor supported by in-house Bioluminescence Resonance Energy Transfer (BRET) data