Wet Refractivity tomographic reconstruction over small areas using an ad-hoc GPS receivers network

One of the most attractive scientific issues in the use of GNSS (Global Navigation Satellite System) signal from a meteorological point of view, is the retrieval of high resolution tropospheric water vapour maps. The real-time (or quasi real-time) knowledge of such distributions could be very useful for several applications, from operative meteorology to atmospheric modeling. Moreover, the exploitation of wet refractivity field reconstruction techniques can be used for atmospheric delay compensation purposes and, as a very promising activity, it could be applied for example to calibrate SAR or Interferometric-SAR (In-SAR) observations for land remote sensing. This is in fact one of the objectives of the European Space Agency project METAWAVE (Mitigation of Electromagnetic Transmission errors induced by Atmospheric Water vapour Effects), in which several techniques were investigated and results were compared to identify a strategy to remove the contribution of water vapour induced propagation delays in In-SAR products. Within this project, the tomographic reconstruction of three dimensional wet refractivity fields on a small atmospheric volume (16km x 20 km x 10 km height, from 2 km to 4 km horizontal resolution and 1 km vertical resolution), was performed considering real tropospheric delays observations acquired by a GNSS network (9 dual frequency GPS receivers) deployed over Como area (Italy), during 12-18 October, 2008. Acquired L1 and L2 carrier phase observations have been processed in terms of hourly averaged Zenith Wet Delays. These vertical informations have been mapped along the correspondent line of sights (by up-sampling at 30 second sample times the 15 minutes GPS satellites positions obtained from IGS files) and inverted using a tomographic procedure. The used algorithm performs a first reconstruction (namely, the tomographic pre-processing) based on generalized inversion mechanisms, in order to define a low resolution first guess for the following step. This second step inverts GPS observables using a more refined algebraic tomographic reconstruction algorithm, in order to improve both vertical and horizontal resolution. Despite limitations due to the network design, internal consistency tests prove the efficiency of the adopted tomographic approach: the rms of the difference between reconstructed and GNSS observed Zenith Wet Delays (ZWD) are in the order of 4 mm. A good agreement is also observed between our ZWDs and corresponding delays obtained by vertically integrating independent wet refractivity fields, taken by co-located meteorological analysis. Finally, during the observing period, reconstructed vertical wet refractivity profiles evolution reveals water vapour variations induced by simple cloud covering. Even if our main goal was to demonstrate the effectiveness in adopting tomographic reconstruction procedures for the evaluation of propagation delays inside water vapour fields, the actual water vapour vertical variability and its evolution with time is well reproduced, demonstrating also the effectiveness of the inferred 3D wet refractivity fields. Even if results obtained were satisfactory, limitations due to the observation geometry, to the GNSS propagation delay information extraction form observables and to the applied tomographic technique will be highlighted, in order to trace the road-map toward future improvements in this challenging fiel

Advanced Vacuum Systems for Analytical Electron Microscopy

Recent technological advancements such as significantly improved power supply stability and polepiece design, as well as increased accelerating voltage all contribute to the primary objective of the scanning electron microscope (SEM): higher resolution. Similarly, the advent of analytical electron microscopy (AEM) has also expanded the scope of applications to include energy-dispersive spectrometry, wavelength-dispersive spectrometry, and electron probe analysis. Specimen contamination and damage has become increasingly problematic as SEMs are used as analytical instruments. In an effort to minimize contamination and etching, and thereby benefit from these advances, cleaner and more efficient vacuum systems are required. Such benefits were realized when, for the first time, a Cameca microprobe\u27s diffusion pump was replaced by a low vibration cryogenic vacuum pump, resulting in faster pump down and lower ultimate vacuum pressures

Spin Chains in an External Magnetic Field. Closure of the Haldane Gap and Effective Field Theories

We investigate both numerically and analytically the behaviour of a spin-1 antiferromagnetic (AFM) isotropic Heisenberg chain in an external magnetic field. Extensive DMRG studies of chains up to N=80 sites extend previous analyses and exhibit the well known phenomenon of the closure of the Haldane gap at a lower critical field H_c1. We obtain an estimate of the gap below H_c1. Above the lower critical field, when the correlation functions exhibit algebraic decay, we obtain the critical exponent as a function of the net magnetization as well as the magnetization curve up to the saturation (upper critical) field H_c2. We argue that, despite the fact that the SO(3) symmetry of the model is explicitly broken by the field, the Haldane phase of the model is still well described by an SO(3) nonlinear sigma-model. A mean-field theory is developed for the latter and its predictions are compared with those of the numerical analysis and with the existing literature.Comment: 11 pages, 4 eps figure

Low mass star formation and subclustering in the HII regions RCW 32, 33 and 27 of the Vela Molecular Ridge. A photometric diagnostics to identify M-type stars

Most stars born in clusters and recent results suggest that star formation (SF) preferentially occurs in subclusters. Studying the morphology and SF history of young clusters is crucial to understanding early SF. We identify the embedded clusters of young stellar objects (YSOs) down to M stars, in the HII regions RCW33, RCW32 and RCW27 of the Vela Molecular Ridge. Our aim is to characterise their properties, such as morphology and extent of the clusters in the three HII regions, derive stellar ages and the connection of the SF history with the environment. Through public photometric surveys such as Gaia, VPHAS, 2MASS and Spitzer/GLIMPSE, we identify YSOs with IR, Halpha and UV excesses, as signature of circumstellar disks and accretion. In addition, we implement a method to distinguish M dwarfs and giants, by comparing the reddening derived in several optical/IR color-color diagrams, assuming suitable theoretical models. Since this diagnostic is sensitive to stellar gravity, the procedure allows us to identify pre-main sequence stars. We find a large population of YSOs showing signatures of circumstellar disks with or without accretion. In addition, with the new technique of M-type star selection, we find a rich population of young M stars with a spatial distribution strongly correlated to the more massive population. We find evidence of three young clusters, with different morphology. In addition, we identify field stars falling in the same region, by securely classifying them as giants and foreground MS stars. We identify the embedded population of YSOs, down to about 0.1 Msun, associated with the HII regions RCW33, RCW32 and RCW27 and the clusters Vela T2, Cr197 and Vela T1, respectively, showing very different morphologies. Our results suggest a decreasing SF rate in Vela T2 and triggered SF in Cr197 and Vela T1.Comment: Accepted for publication in A&A; 20 pages, 22 figures, 6 table

Papillomavirus E5: the smallest oncoprotein with many functions

Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncoproteins of PVs: E5, E6 and E7 are known to contribute to tumour progression. While the oncogenic activities of E6 and E7 are well characterised, the role of E5 is still rather nebulous. The widespread causal association of PVs with cancer makes their study worthwhile not only in humans but also in animal model systems. The Bovine PV (BPV) system has been the most useful animal model in understanding the oncogenic potential of PVs due to the pivotal role of its E5 oncoprotein in cell transformation. This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent

Polymorphism, phonon dynamics and carrier-phonon coupling in pentacene

The crystal structure and phonon dynamics of pentacene is computed with the Quasi Harmonic Lattice Dynamics (QHLD) method, based on atom-atom potential. We show that two crystalline phases of pentacene exist, rather similar in thermodynamic stability and in molecular density. The two phases can be easily distinguished by Raman spectroscopy in the 10-100 cm-1 spectral region. We have not found any temperature induced phase transition, whereas a sluggish phase change to the denser phase is induced by pressure. The bandwidths of the two phases are slightly different. The charge carrier coupling to low-frequency phonons is calculated.Comment: 6 pages, 3 figures. Presented at ICFPAM-

The Commercial Application of Missile/Space Technology, Parts 1 and 2

This report is concerned with the transfer of technology from missile and space programs to non-missile/space applications in the United States. It presents the findings of a University of Denver Research Institute study sponsored by a National Aeronautics and Space Administration (NASA) grant awarded in November 1961. Initial stimulation for the unsolicited proposal leading to this study came from a 1960 Brookings Institution report to NASA, Proposed Studies on the Implications of Peaceful Space Activities for Human Affairs

CSI 2264: Simultaneous optical and X-ray variability in pre-Main Sequence stars. I: Time resolved X-ray spectral analysis during optical dips and accretion bursts in stars with disks

Pre-main sequence stars are variable sources. In stars with disks, this variability is related to the morphology of the inner circumstellar region (<0.1 AU) and that of the photosphere and corona, all impossible to be spatially resolved with present day techniques. This has been the main motivation for the Coordinated Synoptic Investigation of NGC 2264. In this paper, we focus on the stars with disks. We analyze the X-ray spectral properties extracted during optical bursts and dips in order to unveil the nature of these phenomena. We analyze simultaneous CoRoT and Chandra/ACIS-I observations to search for coherent optical and X-ray flux variability in stars with disks. Then, stars are analyzed in two different samples. In stars with variable extinction, we look for a simultaneous increase of optical extinction and X-ray absorption during the optical dips; in stars with accretion bursts, we search for soft X-ray emission and increasing X-ray absorption during the bursts. Results. We find evidence for coherent optical and X-ray flux variability among the stars with variable extinction. In 9/24 stars with optical dips, we observe a simultaneous increase of X-ray absorption and optical extinction. In seven dips, it is possible to calculate the NH/AV ratio in order to infer the composition of the obscuring material. In 5/20 stars with optical accretion bursts, we observe increasing soft X-ray emission during the bursts that we associate to the emission of accreting gas. It is not surprising that these properties are not observed in all the stars with dips and bursts, since favorable geometric configurations are required. The observed variable absorption during the dips is mainly due to dust-free material in accretion streams. In stars with accretion bursts, we observe on average a larger soft X-ray spectral component not observed in non accreting stars.Comment: Accepted for publication by Astronomy & Astrophysic

Neutrophil-tumor cell phagocytosis (cannibalism) in human turoms: an update and literature review

The recognition and removal of apoptotic cells by tissue macrophages and nonprofessional phagocytes, in a process called efferocytosis, is critical for development, tissue homeostasis and resolution of inflammation. Apoptotic bodies arising in tumor tissue are ingested by viable neoplastic cells and by resident macrophages. We described tumor cell phagocytosis of apoptotic neutrophils in human gastric carcinomas. This phenomenon is analogous to neutrophil efferocytosis performed by macrophages and by nonprofessional phagocytes during inflammatory reaction but is distinct by other types of cell-in-cell phenomena including emperipolesis and entosis both cytologically and biologically. In this review, we discussed them in their ultrastructural morphology, physiolo­gical roles, and clinicopathologic implications. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”

Wet Refractivity tomographic reconstruction over small areas using an ad-hoc GPS receivers network

One of the most attractive scientific issues in the use of GNSS (Global Navigation Satellite System) signal from a meteorological point of view, is the retrieval of high resolution tropospheric water vapour maps. The real-time (or quasi real-time) knowledge of such distributions could be very useful for several applications, from operative meteorology to atmospheric modeling. Moreover, the exploitation of wet refractivity field reconstruction techniques can be used for atmospheric delay compensation purposes and, as a very promising activity, it could be applied for example to calibrate SAR or Interferometric-SAR (In-SAR) observations for land remote sensing. This is in fact one of the objectives of the European Space Agency project METAWAVE (Mitigation of Electromagnetic Transmission errors induced by Atmospheric Water vapour Effects), in which several techniques were investigated and results were compared to identify a strategy to remove the contribution of water vapour induced propagation delays in In-SAR products. Within this project, the tomographic reconstruction of three dimensional wet refractivity fields on a small atmospheric volume (16km x 20 km x 10 km height, from 2 km to 4 km horizontal resolution and 1 km vertical resolution), was performed considering real tropospheric delays observations acquired by a GNSS network (9 dual frequency GPS receivers) deployed over Como area (Italy), during 12–18 October, 2008. Acquired L1 and L2 carrier phase observations have been processed in terms of hourly averaged Zenith Wet Delays. These vertical informations have been mapped along the correspondent line of sights (by up-sampling at 30 second sample times the 15 minutes GPS satellites positions obtained from IGS files) and inverted using a tomographic procedure. The used algorithm performs a first reconstruction (namely, the tomographic pre-processing) based on generalized inversion mechanisms, in order to define a low resolution first guess for the following step. This second step inverts GPS observables using a more refined algebraic tomographic reconstruction algorithm, in order to improve both vertical and horizontal resolution. Despite limitations due to the network design, internal consistency tests prove the efficiency of the adopted tomographic approach: the rms of the difference between reconstructed and GNSS observed Zenith Wet Delays (ZWD) are in the order of 4 mm. A good agreement is also observed between our ZWDs and corresponding delays obtained by vertically integrating independent wet refractivity fields, taken by co-located meteorological analysis. Finally, during the observing period, reconstructed vertical wet refractivity profiles evolution reveals water vapour variations induced by simple cloud covering. Even if our main goal was to demonstrate the effectiveness in adopting tomographic reconstruction procedures for the evaluation of propagation delays inside water vapour fields, the actual water vapour vertical variability and its evolution with time is well reproduced, demonstrating also the effectiveness of the inferred 3D wet refractivity fields. Even if results obtained were satisfactory, limitations due to the observation geometry, to the GNSS propagation delay information extraction form observables and to the applied tomographic technique will be highlighted, in order to trace the road-map toward future improvements in this challenging field