AMELIORATING THE SPATIAL RESOLUTION OF HYPERION HYPERSPECTRAL DATA. THE CASE OF ANTIPAROS ISLAND

In this study seven fusion techniques and more especially the Ehlers, Gram-Schmidt, High Pass Filter, Local Mean Matching (LMM), Local Mean and Variance Matching (LMVM), Pansharp and PCA, were used for the fusion of Hyperion hyperspectral data with ALI panchromatic data. The panchromatic data have a spatial resolution of 10m while the hyperspectral data have a spatial resolution of 30m. All the fusion techniques are designed for use with classical multispectral data. Thus, it is quite interesting to investigate the assessment of the common used fusion algorithms with the hyperspectral data. The study area is Antiparos Island in the Aegean Sea

On the Terminal Location Uncertainty in Elliptical Footprints: Application in Air-to-Ground Links

Wireless transmitters (Txs) radiating directionally downwards often generate circular footprints on the ground. In certain scenarios, using elliptical cells can offer increased flexibility for providing user coverage, owing to the unique network characteristics. For instance, an elliptical footprint can be produced when a practical directional antenna with unequal azimuth and elevation half-power beamwidths is used in high-speed railway networks. Another common scenario involves the production of an elliptical footprint when an airborne Tx radiates at an angle by tilting its directional antenna by a few degrees. This paper aims to investigate, for the first time, the association between the random user location within an elliptical coverage area and the performance of a wireless communication link by considering these scenarios. We assume an unmanned aerial vehicle (UAV) as a Tx, although a tall cellular base station tower could also be employed without losing generality. To better understand the impact of random location, we derive relevant distance metrics and investigate the outage probability of the link for the two scenarios, taking both random terminal location and fading impairments into account. The findings may provide valuable insights into the performance of similar wireless systems.Comment: 23 pages, 11 figure

Prognostic DNA methylation markers for sporadic colorectal cancer: a systematic review

Background Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients and that can stratify high-risk early stage patients from low-risk early stage patients are urgently needed for better management of CRC. During the last decades, a large variety of prognostic DNA methylation markers has been published in the literature. However, to date, none of these markers are used in clinical practice. Methods To obtain an overview of the number of published prognostic methylation markers for CRC, the number of markers that was validated independently, and the current level of evidence (LoE), we conducted a systematic review of PubMed, EMBASE, and MEDLINE. In addition, we scored studies based on the REMARK guidelines that were established in order to attain more transparency and complete reporting of prognostic biomarker studies. Eighty-three studies reporting on 123 methylation markers fulfilled the study entry criteria and were scored according to REMARK. Results Sixty-three studies investigated single methylation markers, whereas 20 studies reported combinations of methylation markers. We observed substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology. The median (range) REMARK score for the studies was 10.7 points (4.5 to 17.5) out of a maximum of 20 possible points. The median REMARK score was lower in studies, which reported a p value below 0.05 versus those, which did not (p = 0.005). A borderline statistically significant association was observed between the reported p value of the survival analysis and the size of the study population (p = 0.051). Only 23 out of 123 markers (17%) were investigated in two or more study series. For 12 markers, and two multimarker panels, consistent results were reported in two or more study series. For four markers, the current LoE is level II, for all other markers, the LoE is lower. Conclusion This systematic review reflects that adequate reporting according to REMARK and validation of prognostic methylation markers is absent in the majority of CRC methylation marker studies. However, this systematic review provides a comprehensive overview of published prognostic methylation markers for CRC and highlights the most promising markers that have been published in the last two decades

Evaluation of current therapeutic strategies in Behçet's disease

Behçet's disease (BD) is a chronic relapsing vasculitis with multifunctional pathogenesis. The mucocutaneous and ocular lesions are the commonest manifestations, but BD also affects the musculoskeletal, intestinal, cardiac, and central nervous system. BD therapy is based on the suppression of the inflammatory process, using immunomodulating and immunosuppressive agents. In selected cases, invasive procedures may be required. © Clinical Rheumatology 2010

Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease

 Behçet’s disease is a chronic, recurrent, inflammatory disorder characterized by orogenital ulcers and skin lesions; serious manifestations also include ocular, large vessel, gastrointestinal and neurological involvement. Genetic and unknown environmental factors modify the wide clinical spectrum of the disease. During the long clinical course of the disease, testicular and epididymal involvement has been reported, with scrotal pain and swelling being the most common symptoms. In this review, we discuss the various aspects of epididymo-orchitis in Behcet’s disease patients, and we evaluate the diagnostic approaches as well as the empirical therapeutic modalities of this entity.

Juvenile Adamantiades-Behçet Disease

Adamantiades-Behçet disease (ABD) is a chronic, multisystemic, recurrent, inflammatory vascular disorder of unknown etiology. Patients with symptoms initially appearing at the age of 16 or less are considered as cases of juvenile-onset ABD (JABD). JABD is relatively rare compared to ABD of adults, and only case reports and case studies have been published regarding this subtype of the disease. Epidemiology, clinical features, diagnosis and treatment of JABD are discussed in this review. © 2016 S. Karger AG, Basel

Juvenile Adamantiades-Behçet disease

Adamantiades-Behçet disease (ABD) is a chronic, multisystemic, recurrent, inflammatory vascular disorder of unknown etiology. Patients with symptoms initially appearing at the age of 16 or less are considered as cases of juvenile-onset ABD (JABD). JABD is relatively rare compared to ABD of adults, and only case reports and case studies have been published regarding this subtype of the disease. Epidemiology, clinical features, diagnosis and treatment of JABD are discussed in this review