Cordies:Expressive event correlation in distributed systems

Complex Event Processing (CEP) is the method of choice for the observation of system states and situations by means of events. A number of systems have been introduced that provide CEP in selected environments. Some are restricted to centralised systems, or to systems with synchronous communication, or to a limited space of event relations that are defined in advance. Many modern systems, though, are inherently distributed and asynchronous, and require a more powerful CEP. We present Cordies, a distributed system for the detection of correlated events that is designed for the operation in large-scale, heterogeneous networks and adapts dynamically to changing network conditions. With its expressive language to describe event relations, it is suitable for environments where neither the event space nor the situations of interest are predefined but are constantly adapted. In addition, Cordies supports Quality-of-Service (QoS) for communication in distributed event correlation detection

Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing

BACKGROUND: Somatosensation of the mammalian head is mainly mediated by the trigeminal nerve that provides innervation of diverse tissues like the face skin, the conjunctiva of the eyes, blood vessels and the mucouse membranes of the oral and nasal cavities. Trigeminal perception encompasses thermosensation, touch, and pain. Trigeminal chemosensation from the nasal epithelia mainly evokes stinging, burning, or pungent sensations. In vitro characterization of trigeminal primary sensory neurons derives largely from analysis of complete neuronal populations prepared from sensory ganglia. Thus, functional properties of primary trigeminal afferents depending on the area of innervation remain largely unclear. RESULTS: We established a PrV based tracing technique to identify nasal and cutaneous trigeminal neurons in vitro. This approach allowed analysis and comparison of identified primary afferents by means of electrophysiological and imaging measurement techniques. Neurons were challenged with several agonists that were reported to exhibit specificity for known receptors, including TRP channels and purinergic receptors. In addition, TTX sensitivity of sodium currents and IB4 binding was investigated. Compared with cutaneous neurons, a larger fraction of nasal trigeminal neurons showed sensitivity for menthol and capsaicin. These findings pointed to TRPM8 and TRPV1 receptor protein expression largely in nasal neurons whereas for cutaneous neurons these receptors are present only in a smaller fraction. The majority of nasal neurons lacked P2X(3 )receptor-mediated currents but showed P2X(2)-mediated responses when stimulated with ATP. Interestingly, cutaneous neurons revealed largely TTX resistant sodium currents. A significantly higher fraction of nasal and cutaneous afferents showed IB4 binding when compared to randomly chosen trigeminal neurons. CONCLUSION: In conclusion, the usability of PrV mediated tracing of primary afferents was demonstrated. Using this technique it could be shown that compared with neurons innervating the skin nasal trigeminal neurons reveal pronounced chemosensitivity for TRPM8 and TRPV1 channel agonists and only partially meet properties typical for nociceptors. In contrast to P2X(3 )receptors, TRPM8 and TRPV1 receptors seem to be of pronounced physiological relevance for intranasal trigeminal sensation

Gravity compensation in complex plasmas by application of a temperature gradient

Micron sized particles are suspended or even lifted up in a gas by thermophoresis. This allows the study of many processes occurring in strongly coupled complex plasmas at the kinetic level in a relatively stress-free environment. First results are presented. The technique is also of interest for technological applications.Comment: 4 pages, 4 figures, final version to be published in Phys. Rev. Let