The First Science Results from SPHERE: Disproving the Predicted Brown Dwarf around V471 Tau

Variations of eclipse arrival times have recently been detected in several post common envelope binaries consisting of a white dwarf and a main sequence companion star. The generally favoured explanation for these timing variations is the gravitational pull of one or more circumbinary substellar objects periodically moving the center of mass of the host binary. Using the new extreme-AO instrument SPHERE, we image the prototype eclipsing post-common envelope binary V471 Tau in search of the brown dwarf that is believed to be responsible for variations in its eclipse arrival times. We report that an unprecedented contrast of 12.1 magnitudes in the H band at a separation of 260 mas was achieved, but resulted in a non-detection. This implies that there is no brown dwarf present in the system unless it is three magnitudes fainter than predicted by evolutionary track models, and provides damaging evidence against the circumbinary interpretation of eclipse timing variations. In the case of V471 Tau, a more consistent explanation is offered with the Applegate mechanism, in which these variations are prescribed to changes in the quadrupole moment within the main-sequence sta

Sistema de informacion de apoyo a la licitacion y adjudicacion de obras sanitarias

69 p.Se construirá un sistema de Información para el proceso de licitación y adjudicación de obras sanitarias en ESSAM S.A. Este sistema considera el registro de información proveniente desde distintas fuentes, como por ejemplo, el registro de las bases de una determinada obra, las propuestas presentadas por los contratistas y las calificaciones que obtengan en terreno por la realización de una obra en particular. Con la información recolectada, el sistema debe ser capaz de: primero, gestionar el proceso de licitación y adjudicación; segundo, realizar un análisis multicriterio de las propuestas presentadas por los contratistas participantes de una licitación; tercero, construir un historial de las calificaciones de contratistas en obras ejecutadas para ESSAM S.A.; cuarto, llevar un registro cruzado de obras y contratistas. En este sentido, el sistema de información contendrá un subsistema de ayuda a la decisión

ANÁLISIS CLÍNICO Y ECONÓMICO DE LA HISTERECTOMÍA ABDOMINAL VERSUS LA HISTERECTOMÍA VAGINAL EN EL HOSPITAL CLÍNICO DE LA UNIVERSIDAD DE CHILE: REVISIÓN DE 2.338 CASOS

Antecedentes: La histerectomía es una intervención quirúrgica frecuente y de alto costo. Después de la operación cesárea, es el segundo procedimiento quirúrgico más frecuente en ginecología. Objetivos: Evaluar la relación costo/efectividad de la histerectomía vaginal versus la histerectomía abdominal. Método: Estudio retrospectivo observacional, en 2.338 pacientes sometidas a histerectomía por patología benigna en el Servicio de Ginecología del Hospital Clínico de la Universidad de Chile, en el período comprendido entre enero de 1997 a diciembre de 2005. Se analizaron variables clínicas y de costo entre las dos vías de abordaje. Resultados: La edad de las pacientes fluctuó entre 27 y 86 años. De las 2.338 histerectomías, la vía vaginal correspondió al 36,9% y la abdominal en el 63,1%; con una tasa de complicaciones de 29,8/100 mujeres operadas vaginalmente y de 42,8/100 mujeres operadas abdominalmente. Conclusión: Este estudio sugiere que el abordaje vaginal se asoció a tiempos operatorios más cortos, menor número de complicaciones y a costos más bajos que la vía abdomina

Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD

<p>Abstract</p> <p>Background</p> <p>A suggested role for T cells in COPD pathogenesis is based on associations between increased lung cytotoxic T lymphocyte (CD8⁺) numbers and airflow limitation. CD69 is an early T cell activation marker. Natural Killer cell group 2 D (NKG2D) receptors are co-stimulatory molecules induced on CD8⁺T cells upon activation. The activating function of NKG2 D is triggered by binding to MHC class 1 chain-related (MIC) molecules A and B, expressed on surface of stressed epithelial cells. The aim of this study was to evaluate the expression of MIC A and B in the bronchial epithelium and NKG2 D and CD69 on BAL lymphocytes in subjects with COPD, compared to smokers with normal lung function and healthy never-smokers.</p> <p>Methods</p> <p>Bronchoscopy with airway lavages and endobronchial mucosal biopsy sampling was performed in 35 patients with COPD, 21 healthy never-smokers and 16 smokers with normal lung function. Biopsies were immunohistochemically stained and BAL lymphocyte subsets were determined using flow cytometry.</p> <p>Results</p> <p>Epithelial CD3⁺lymphocytes in bronchial biopsies were increased in both smokers with normal lung function and in COPD patients, compared to never-smokers. Epithelial CD8⁺lymphocyte numbers were higher in the COPD group compared to never-smoking controls. Among gated CD3⁺cells in BAL, the percentage of CD8⁺NKG2D⁺cells was enhanced in patients with COPD and smokers with normal lung function, compared to never-smokers. The percentage of CD8⁺CD69⁺cells and cell surface expression of CD69 were enhanced in patients with COPD and smokers with normal lung function, compared to never-smokers. No changes in the expression of MIC A or MIC B in the airway epithelium could be detected between the groups, whereas significantly decreased soluble MICB was detected in bronchial wash from smokers with normal lung function, compared to never-smokers.</p> <p>Conclusions</p> <p>In COPD, we found increased numbers of cytotoxic T cells in both bronchial epithelium and airway lumen. Further, the proportions of CD69- and NKG2D-expressing cytotoxic T cells in BAL fluid were enhanced in both subjects with COPD and smokers with normal lung function and increased expression of CD69 was found on CD8⁺cells, indicating the cigarette smoke exposure-induced expansion of activated cytotoxic T cells, which potentially can respond to stressed epithelial cells.</p

Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema

BACKGROUND: Hepatocyte and keratinocyte growth factors are key growth factors in the process of alveolar repair. We hypothesized that excessive alveolar destruction observed in lung emphysema involves impaired expression of hepatocyte and keratinocyte growth factors or their respective receptors, c-met and keratinocyte growth factor receptor. The aim of our study was to compare the expression of hepatocyte and keratinocyte growth factors and their receptors in lung samples from 3 groups of patients: emphysema; smokers without emphysema and non-smokers without emphysema. METHODS: Hepatocyte and keratinocyte growth factor proteins were analysed by immunoassay and western blot; mRNA expression was measured by real time quantitative polymerase chain reaction. RESULTS: Hepatocyte and keratinocyte growth factors, c-met and keratinocyte growth factor receptor mRNA levels were similar in emphysema and non-emphysema patients. Hepatocyte growth factor mRNA correlated negatively with FEV1 and the FEV1/FVC ratio both in emphysema patients and in smokers with or without emphysema. Hepatocyte and keratinocyte growth factor protein concentrations were similar in all patients' groups. CONCLUSION: The expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema. Hepatocyte growth factor mRNA correlates with the severity of airflow obstruction in smokers

Polymorphism of viral dsRNA in Xanthophyllomyces dendrorhous strains isolated from different geographic areas

<p>Abstract</p> <p>Background</p> <p>Strains of the astaxanthin producing yeast <it>Xanthophyllomyces dendrorhous </it>have been isolated from different cold regions around the earth, and the presence of double stranded RNA (dsRNA) elements was described in some isolates. This kind of viruses is widely distributed among yeasts and filamentous fungi and, although generally are cryptic in function, their studies have been a key factor in the knowledge of important fungi. In this work, the characterization and genetic relationships among dsRNA elements were determined in strains representatives of almost all regions of the earth where <it>X. dendrorhous </it>have been isolated.</p> <p>Results</p> <p>Almost all strains of <it>X. dendrorhous </it>analyzed carry one, two or four dsRNA elements, of molecular sizes in the range from 0.8 to 5.0 kb. Different dsRNA-patterns were observed in strains with different geographic origin, being L1 (5.0 kb) the common dsRNA element. By hybridization assays a high genomic polymorphism was observed among L1 dsRNAs of different <it>X. dendrorhous </it>strains. Contrary, hybridization was observed between L1 and L2 dsRNAs of strains from same or different regions, while the dsRNA elements of minor sizes (M, S1, and S2) present in several strains did not show hybridization with neither L1 or L2 dsRNAs. Along the growth curve of UCD 67-385 (harboring four dsRNAs) an increase of L2 relative to L1 dsRNA was observed, whiles the S1/L1 ratio remains constant, as well as the M/L1 ratio of Patagonian strain. Strains cured of S2 dsRNA were obtained by treatment with anisomycin, and comparison of its dsRNA contents with uncured strain, revealed an increase of L1 dsRNA while the L2 and S1 dsRNA remain unaltered.</p> <p>Conclusion</p> <p>The dsRNA elements of <it>X. dendrorhous </it>are highly variable in size and sequence, and the dsRNA pattern is specific to the geographic region of isolation. Each L1 and L2 dsRNA are viral elements able to self replicate and to coexist into a cell, and L1 and S2 dsRNAs elements could be part of a helper/satellite virus system in <it>X. dendrorhous</it>.</p

Young Stellar Clusters Containing Massive Young Stellar Objects in the VVV Survey

This is an author-created, un-copyedited version of an article published in The Astronomical Journal. IOP Publishing is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at: at doi: https://doi.org/10.3847/0004-6256/152/3/74. © 2016. The American Astronomical Society. All rights reserved. IOPScience PublishingThe purpose of this research is to study the connection of global properties of eight young stellar clusters projected in the Vista Variables in the Via Lactea (VVV) ESO Large Public Survey disk area and their young stellar object population. The analysis in based on the combination of spectroscopic parallax-based reddening and distance determinations with main sequence and pre-main sequence ishochrone fitting to determine the basic parameters (reddening, age, distance) of the sample clusters. The lower mass limit estimations show that all clusters are low or intermediate mass (between 110 and 1800 Mo), the slope Gamma of the obtained present-day mass functions of the clusters is close to the Kroupa initial mass function. On the other hand, the young stellar objects in the surrounding cluster's fields are classified by low resolution spectra, spectral energy distribution fit with theoretical predictions, and variability, taking advantage of multi-epoch VVV observations. All spectroscopically confirmed young stellar objects (except one) are found to be massive (more than 8 Mo). Using VVV and GLIMPSE color-color cuts we have selected a large number of new young stellar object candidates, which are checked for variability and 57% are found to show at least low-amplitude variations. In few cases it was possible to distinguish between YSO and AGB classification on the basis of the light curves.Peer reviewedFinal Accepted Versio

Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations

Airway inflammation increases during acute exacerbations of COPD. Extrinsic factors, such as airway infections, increased air pollution, and intrinsic factors, such as increased oxidative stress and altered immunity may contribute to this increase. The evidence for this and the potential mechanisms by which various aetiological agents increase inflammation during COPD exacerbations is reviewed. The pathophysiologic consequences of increased airway inflammation during COPD exacerbations are also discussed. This review aims to establish a cause and effect relationship between etiological factors of increased airway inflammation and COPD exacerbations based on recently published data. Although it can be speculated that reducing inflammation may prevent and/or treat COPD exacerbations, the existing anti-inflammatory treatments are modestly effective