Illusory resizing of the painful knee is analgesic in symptomatic knee osteoarthritis

Background. Experimental and clinical evidence support a link between body represen- tations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size are analgesic; (ii) cumulative analgesic effects occur with sustained or repeated illusions. Methods. Participants with knee OA underwent eight conditions (order randomised): stretch and shrink visuotactile (congruent) illusions and corresponding visual, tactile and incongruent control conditions. Knee pain intensity (0-100 numerical rating scale; 0 = no pain at all and 100 D worst pain imaginable) was assessed pre- and post- condition. Condition (visuotactile illusion vs control) × Time (pre-/post-condition) repeated measure ANOVAs evaluated the effect on pain. In each participant, the most beneficial illusion was sustained for 3 min and was repeated 10 times (each during two sessions); paired t -tests compared pain at time 0 and 180s (sustained) and between illusion 1 and illusion 10 (repeated). Results. Visuotactile illusions decreased pain by an average of 7.8 points (95% CI [2.0-13.5]) which corresponds to a 25% reduction in pain, but the tactile only and visual only control conditions did not (Condition × Time interaction: p = 0:028). Visuotactile illusions did not differ from incongruent control conditions where the same visual manipulation occurred, but did differ when only the same tactile input was applied. Sustained illusions prolonged analgesia, but did not increase it. Repeated illusions increased the analgesic effect with an average pain decrease of 20 points (95% CI [6.9-33.1])-corresponding to a 40% pain reduction. Discussion. Visuotactile illusions are analgesic in people with knee OA. Our results suggest that visual input plays a critical role in pain relief, but that analgesia requires multisensory input. That visual and tactile input is needed for analgesia, supports multisensory modulation processes as a possible explanatory mechanism. Further research exploring the neural underpinnings of these visuotactile illusions is needed. For potential clinical applications, future research using a greater dosage in larger samples is warranted

Embodying the illusion of a strong, fit back in people with chronic low back pain. A pilot proof-of-concept study

Objective: This proof-of-concept pilot study aimed to investigate if a visual illusion that altered the size and muscularity of the back could be embodied and alter perception of the back. Methods: The back visual illusions were created using the MIRAGE multisensory illusion system. Participants watched real-time footage of a modified version of their own back from behind. Participants undertook one experimental condition, in which the image portrayed a muscled, fit-looking back (Strong), and two control conditions (Reshaped and Normal) during a lifting task. Embodiment, back perception as well as pain intensity and beliefs about the back during lifting were assessed. Results: Two participants with low back pain were recruited for this study: one with altered body perception and negative back beliefs (Participant A) and one with normal perception and beliefs (Participant B). Participant A embodied the Strong condition and pain and fear were less and both perceived strength and confidence were more than for the Normal or the Reshaped condition. Participant B did not embody the Strong condition and reported similar levels of pain, fear strength and confidence across all three conditions. Discussion: An illusion that makes the back look strong successfully induced embodiment of a visually modified back during a lifting task in a low back pain patient with altered body perception. Both participants tolerated the illusion, there were no adverse effects, and we gained preliminary evidence that the approach may have therapeutic potential

Thermal conductivity of building materials: an overview of its determination

A range of instruments are available to measure thermal conductivity of building materials. Some of these tools are heat-flow meter, hot plate, hot box and heat transfer analyzer. Thermal conductivity data derived by using different instruments can be different from each other. Implication of these variations in thermal conductivity is significant in terms of commercial profile of the insulations and also in terms of calculating energy saving in large scale use of that specific insulation. Thus it is important to know which of the measuring instrument for thermal conductivity can produce relatively accurate and representative result. This paper firstly looks at the methods and instrument for measuring thermal conductivity of building materials and secondly compares and analyses the results of testing thermal conductivity of fibrous insulations using a heat analyzer and a hot plate

The specialty choices of graduates from Brighton and Sussex Medical School: a longitudinal cohort study

BACKGROUND Since 2007 junior doctors in the UK have had to make major career decisions at a point when previously many had not yet chosen a specialty. This study examined when doctors in this new system make specialty choices, which factors influence choices, and whether doctors who choose a specialty they were interested in at medical school are more confident in their choice than those doctors whose interests change post-graduation. METHODS Two cohorts of students in their penultimate year at one medical school (n = 227/239) were asked which specialty interested them as a career. Two years later, 210/227 were sent a questionnaire measuring actual specialty chosen, confidence, influence of perceptions of the specialty and experiences on choice, satisfaction with medicine, personality, self-efficacy, and demographics. Medical school and post-graduation choices in the same category were deemed 'stable'. Predictors of stability, and of not having chosen a specialty, were calculated using bootstrapped logistic regression. Differences between specialties on questionnaire factors were analysed. RESULTS 50% responded (n = 105/277; 44% of the 239 Year 4 students). 65% specialty choices were 'stable'. Factors univariately associated with stability were specialty chosen, having enjoyed the specialty at medical school or since starting work, having first considered the specialty earlier. A regression found doctors who chose psychiatry were more likely to have changed choice than those who chose general practice. Confidence in the choice was not associated with stability. Those who chose general practice valued lifestyle factors. A psychiatry choice was associated with needing a job and using one's intellect to help others. The decision to choose surgical training tended to be made early. Not having applied for specialty training was associated with being lower on agreeableness and conscientiousness. CONCLUSION Medical school experiences are important in specialty choice but experiences post-graduation remain significant, particularly in some specialties (psychiatry in our sample). Career guidance is important at medical school and should be continued post-graduation, with senior clinicians supported in advising juniors. Careers advice in the first year post-graduation may be particularly important, especially for specialties which have difficulty recruiting or are poorly represented at medical school

The Response of Ionization Chambers to Relativistic Heavy Nuclei

As part of a recent calibration at the LBL Bevalac for the Heavy Nuclei Experiment on HEAO-3, we have compared the response of a set of laboratory ionization chambers to beams of _(26)Fe, _(36)Kr, _(54)Xe, _(67)Ho, and _(79)Au nuclei at maximum energies ranging from 1666 MeV/amu for Fe to 1049 MeV /amu for Au. The response of these chambers shows a significant deviation from the expected energy dependence, but only a slight deviation from Z^2 scaling

Structural-Properties Of Amorphous Hydrogenated Carbon .1. A High-Resolution Neutron-Diffraction Study

The structure of samples of amorphous hydrogenated carbon, prepared from acetylene and propane precursors, containing 35 and 32 at.% hydrogen, respectively, was investigated by time-of-flight neutron diffraction in the range 0.2-50 angstrom-1 using the ISIS spallation source. The large dynamic range of the data ensures a real-space resolution sufficient to reveal directly the proportions of sp2 and sp3 hybridized carbon. The results show that, in these hard carbon materials, the carbon-atom sites are predominantly sp2 bonded, and the carbon-carbon single bond:carbon-carbon double bond ratio is about 2.5:1. The detailed information on atomic correlations thus provided is used to discuss current structural models, and in particular the data are used to show that these models require significant modification

Embodying the illusion of a strong, fit back in people with chronic low back pain. A pilot proof-of-concept study

Objective: This proof-of-concept pilot study aimed to investigate if a visual illusion that altered the size and muscularity of the back could be embodied and alter perception of the back. Methods: The back visual illusions were created using the MIRAGE multisensory illusion system. Participants watched real-time footage of a modified version of their own back from behind. Participants undertook one experimental condition, in which the image portrayed a muscled, fit-looking back (Strong), and two control conditions (Reshaped and Normal) during a lifting task. Embodiment, back perception as well as pain intensity and beliefs about the back during lifting were assessed. Results: Two participants with low back pain were recruited for this study: one with altered body perception and negative back beliefs (Participant A) and one with normal perception and beliefs (Participant B). Participant A embodied the Strong condition and pain and fear were less and both perceived strength and confidence were more than for the Normal or the Reshaped condition. Participant B did not embody the Strong condition and reported similar levels of pain, fear strength and confidence across all three conditions. Discussion: An illusion that makes the back look strong successfully induced embodiment of a visually modified back during a lifting task in a low back pain patient with altered body perception. Both participants tolerated the illusion, there were no adverse effects, and we gained preliminary evidence that the approach may have therapeutic potential

A Multi-Component Measurement of the Cosmic Ray Composition Between 10^{17} eV and 10^{18} eV

The average mass composition of cosmic rays with primary energies between $10^{17}$eV and $10^{18}$eV has been studied using a hybrid detector consisting of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon array. Measurements have been made of the change in the depth of shower maximum, $X_{max}$, and in the change in the muon density at a fixed core location, $\rho_\mu(600m)$, as a function of energy. The composition has also been evaluated in terms of the combination of $X_{max}$ and $\rho_\mu(600m)$. The results show that the composition is changing from a heavy to lighter mix as the energy increases.Comment: 14 pages including 3 figures in revtex epsf style, submited to PR

Owning an overweight or underweight body: distinguishing the physical, experienced and virtual body

Our bodies are the most intimately familiar objects we encounter in our perceptual environment. Virtual reality provides a unique method to allow us to experience having a very different body from our own, thereby providing a valuable method to explore the plasticity of body representation. In this paper, we show that women can experience ownership over a whole virtual body that is considerably smaller or larger than their physical body. In order to gain a better understanding of the mechanisms underlying body ownership, we use an embodiment questionnaire, and introduce two new behavioral response measures: an affordance estimation task (indirect measure of body size) and a body size estimation task (direct measure of body size). Interestingly, after viewing the virtual body from first person perspective, both the affordance and the body size estimation tasks indicate a change in the perception of the size of the participant’s experienced body. The change is biased by the size of the virtual body (overweight or underweight). Another novel aspect of our study is that we distinguish between the physical, experienced and virtual bodies, by asking participants to provide affordance and body size estimations for each of the three bodies separately. This methodological point is important for virtual reality experiments investigating body ownership of a virtual body, because it offers a better understanding of which cues (e.g. visual, proprioceptive, memory, or a combination thereof) influence body perception, and whether the impact of these cues can vary between different setups

Constraints on Gamma-ray Emission from the Galactic Plane at 300 TeV

We describe a new search for diffuse ultrahigh energy gamma-ray emission associated with molecular clouds in the galactic disk. The Chicago Air Shower Array (CASA), operating in coincidence with the Michigan muon array (MIA), has recorded over 2.2 x 10^{9} air showers from April 4, 1990 to October 7, 1995. We search for gamma rays based upon the muon content of air showers arriving from the direction of the galactic plane. We find no significant evidence for diffuse gamma-ray emission, and we set an upper limit on the ratio of gamma rays to normal hadronic cosmic rays at less than 2.4 x 10^{-5} at 310 TeV (90% confidence limit) from the galactic plane region: (50 degrees < l < 200 degrees); -5 degrees < b < 5 degrees). This limit places a strong constraint on models for emission from molecular clouds in the galaxy. We rule out significant spectral hardening in the outer galaxy, and conclude that emission from the plane at these energies is likely to be dominated by the decay of neutral pions resulting from cosmic rays interactions with passive target gas molecules.Comment: Astrophysical Journal, submitted, 11 pages, AASTeX Latex, 3 Postscript figure