Parametric thermal analysis for the optimization of Double Walled Tubes layout in the Water Cooled Lithium Lead inboard blanket of DEMO fusion reactor

Within the roadmap that will lead to the nuclear fusion exploitation for electric energy generation, the construction of a DEMOnstration (DEMO) reactor is, probably, the most important milestone to be reached since it will demonstrate the technological feasibility and economic competitiveness of an industrial-scale nuclear fusion reactor. In order to reach this goal, several European universities and research centres have joined their efforts in the EUROfusion action, funded by HORIZON 2020 UE programme. Within the framework of EUROfusion research activities, ENEA and University of Palermo are involved in the design of the Water-Cooled Lithium Lead Breeding Blanket (WCLL BB), that is one of the two BB concepts under consideration to be adopted in the DEMO reactor. It is mainly characterized by a liquid lithium-lead eutectic alloy acting as breeder (lithium) and neutron multiplier (lead), as well as by subcooled pressurized water as coolant. Two separate circuits, both characterized by a pressure of 15.5 MPa and inlet/outlet temperatures of 295 °C/328 °C, are deputed to cool down the First Wall (FW) and the Breeder Zone (BZ). The former consists in a system of radial-toroidal-radial C-shaped squared channels where countercurrent water flow occurs while the latter relies in the use of bundles of poloidal-radial Double Walled Tubes (DWTs) housed within the breeder. A parametric thermal study has been carried out in order to assess the best DWTs' layout assuring that the structural material maximum temperature does not overcome the allowable limit of 550 °C and that the overall coolant thermal rise fulfils the design target value of 33 °C. The study has been performed following a theoretical-numerical approach based on the Finite Element Method (FEM) and adopting the quoted Abaqus FEM code. Main assumptions and models together with results obtained are herewith reported and critically discussed

Additive effect of non-alcoholic fatty liver disease on metabolic syndrome-related endothelial dysfunction in hypertensive patients

Metabolic syndrome (MS) is characterized by an increased risk of incident diabetes and cardiovascular (CV) events, identifying insulin resistance (IR) and endothelial dysfunction as key elements. Moreover, non-alcoholic fatty liver disease (NAFLD) is bidirectionally linked with MS as a consequence of metabolic and inflammatory abnormalities. We addressed the question if the evolution in NAFLD might worsen endothelium-dependent vasodilating response in MS hypertensives. We recruited 272 Caucasian newly-diagnosed never-treated hypertensive outpatients divided into three groups according to the presence/absence of MS alone or in combination with NAFLD. MS and NAFLD were defined according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) and non-invasive fatty liver index, respectively. We determined IR by using the homeostasis model assessment (HOMA) index. Vascular function, as forearm blood flow (FBF), was determined through strain-gauge plethysmography after intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside. MS+NAFLD+ group showed worse metabolic, inflammatory and vascular profiles compared with MS-NAFLD- and MS+NAFLD-. HOMA resulted in being the strongest predictor of FBF both in the MS+NAFLD- and in the MS+NAFLD+ groups, accounting for 20.5% and 33.2% of its variation, respectively. In conclusion, we demonstrated that MS+NAFLD+ hypertensives show a worse endothelium-dependent vasodilation compared with MS+NAFLD-, allowing for consideration of NAFLD as an early marker of endothelial dysfunction in hypertensives

A workload-aware energy model for virtual machine migration

Energy consumption has become a significant issue for data centres. Assessing their consumption requires precise and detailed models. In the latter years, many models have been proposed, but most of them either do not consider energy consumption related to virtual machine migration or do not consider the variation of the workload on (1) the virtual machines (VM) and (2) the physical machines hosting the VMs. In this paper, we show that omitting migration and workload variation from the models could lead to misleading consumption estimates. Then, we propose a new model for data centre energy consumption that takes into account the previously omitted model parameters and provides accurate energy consumption predictions for paravirtualised virtual machines running on homogeneous hosts. The new model's accuracy is evaluated with a comprehensive set of operational scenarios. With the use of these scenarios we present a comparative analysis of our model with similar state-of-the-art models for energy consumption of VM Migration, showing an improvement up to 24% in accuracy of prediction. © 2015 IEEE

Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension

Objectives: Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value $155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes (T2D) and for subclinical organ damage. Thus, we addressed the question if 1-hour post-load plasma glucose levels, affects PWV and its central hemodynamic correlates, as augmentation pressure (AP) and augmentation index (AI). Methods: We enrolled 584 newly diagnosed hypertensives. All patients underwent OGTT and measurements of PWV, AP and AI. Insulin sensitivity was assessed by Matsuda-index. Results: Among participants, 424 were NGT and 160 had impaired glucose tolerance (IGT). Of 424 NGT, 278 had 1-h postload plasma glucose ,155 mg/dl (NGT,155) and 146 had 1-h post-load plasma glucose$155 mg/dl (NGT$155). NGT$155 had a worse insulin sensitivity and higher hs-CRP than NGT,155, similar to IGT subjects. In addition, NGT $155 in comparison with NGT,155 had higher central systolic blood pressure (134612 vs 131610 mmHg), as well as PWV (8.463.7 vs 6.761.7 m/s), AP (12.567.1 vs 9.865.7 mmHg) and AI (29.4611.9 vs 25.1612.4 regression analysis, 1-h post-load plasma glucose resulted the major determinant of all indices of vascular stiffness. Conclusion: Hypertensive NGT$155 subjects, compared with NGT,155, have higher PWV and its hemodynamic correlates that increase their cardiovascular risk profile

Ketogenic diet-induced weight loss is associated with an increase in vitamin d levels in obese adults

Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity. A ketogenic diet has proven to be very effective for weight loss, especially in reducing fat mass while preserving fat-free mass. The aim of this study was to investigate the effect of a ketogenic diet-induced weight loss on vitamin D status in a population of obese adults. We enrolled 56 obese outpatients, prescribed with either traditional standard hypocaloric Mediterranean diet (SHMD) or very low-calorie ketogenic diet (VLCKD). Serum 25(OH)D concentrations were measured by chemiluminescence. The mean value of serum 25-hydroxyvitamin D (25(OH)D) concentrations in the whole population at baseline was 17.8 +/- 5.6 ng/mL, without differences between groups. After 12 months of dietetic treatment, in VLCKD patients serum 25(OH)D concentrations increased from 18.4 +/- 5.9 to 29.3 +/- 6.8 ng/mL (p < 0.0001), vs 17.5 +/- 6.1 to 21.3 +/- 7.6 ng/mL (p = 0.067) in the SHMD group (for each kilogram of weight loss, 25(OH)D concentration increased 0.39 and 0.13 ng/mL in the VLCKD and in the SHMD groups, respectively). In the VLCKD group, the increase in serum 25(OH)D concentrations was strongly associated with body mass index, waist circumference, and fatty mass variation. In a multiple regression analysis, fatty mass was the strongest independent predictor of serum 25(OH)D concentration, explaining 15.6%, 3.3%, and 9.4% of its variation in the whole population, in SHMD, and VLCKD groups, respectively. We also observed a greater reduction of inflammation (evaluated by high-sensitivity C reactive protein (hsCRP) values) and a greater improvement in glucose homeostasis, confirmed by a reduction of HOMA values, in the VLCKD versus the SHMD group. Taken together, all these data suggest that a dietetic regimen, which implies a great reduction of fat mass, can improve vitamin D status in the obese

Sensitivity to reward and punishment: Associations with diet, alcohol consumption, and smoking

This study examined whether sensitivity to reward predicts a range of potentially health-damaging behaviours. Secondary objectives were to explore the relationship between these behaviours and sensitivity to punishment. Sensitivity to reward and punishment were assessed among 184 individuals using questionnaire measures of Behavioural Approach System (BAS) and Behavioural Inhibition System (BIS) sensitivity. Participants also completed a food frequency questionnaire and measures of alcohol consumption and smoking. Higher BAS sensitivity predicted higher fat intake, higher alcohol consumption, greater likelihood of binge drinking, greater likelihood of being a smoker and, amongst smokers, smoking frequency. Higher BIS sensitivity predicted lower alcohol consumption but higher sugar intake. Thus, sensitivity to reward appears to be a risk factor for lifestyle behaviours that contribute to poor health. Whilst BIS sensitivity seems to offer some protection with respect to alcohol intake, the results suggest that this does not extend to health-related behaviours, in which the negative consequences may be less immediate. Instead, BIS sensitivity predicted higher sugar intake. This is consistent with the view that BIS sensitivity leads to higher anxiety, which individuals may attempt to regulate by indulging in sugary foods

Attitude toward protest uniquely predicts (normative and nonnormative) political action by (advantaged and disadvantaged) group members

This is the author accepted manuscript. The final version is available on open access via the DOI in this recordOpen Practices: All data and materials for Studies 1-5 have been made publicly available via Open Science Framework and can be accessed at https://osf.io/emk5j. The plan for Study 4 was preregistered at Open Science Framework (https://osf.io/emk5j). This article has received badges for Open Data, Open Materials, and Preregistration. More information about the Open Practices badges can be found at https://osf.io/tvyxz/wiki/home/.We find evidence that explicit (but not implicit) measures of general attitude towards protest uniquely predict normative and nonnormative political action tendencies, and behavior, over and above extant models of political action. Protest attitude uniquely predicts both the political action tendencies of members of disadvantaged groups and willingness to engage in solidarity-based action on behalf of such groups. Furthermore, we find some evidence that protest attitude is able to account for the effects of mobilization messages over a political issue; these messages increase political action tendencies by making attitude towards protest more positive. The results indicate that overall attitude toward protest reflects a wide array of affective, cognitive, and behavioral factors associated with protest that more specific, established predictors of collective political action do not tap. As such, general protest attitude offers an important addition to extant models of collective political action and efforts to examine the psychological processes underpinning political cognition and action.Economic and Social Research Council (ESRC

Green composites based on pla and agricultural or marine waste prepared by fdm

Three dimensional-printability of green composites is recently growing in importance and interest, especially in the view of feasibility to valorize agricultural and marine waste to attain green fillers capable of reducing bioplastic costs, without compromising their processability and performance from an environmental and mechanical standpoint. In this work, two lignocellulosic fillers, obtained from Opuntia ficus indica and Posidonia oceanica, were added to PLA and processed by FDM. Among the 3D printed biocomposites investigated, slight differences could be found in terms of PLA molecular weight and filler aspect ratio. It was shown that it is possible to replace up to 20% of bioplastic with low cost and ecofriendly natural fillers, without significantly modifying the processability and the mechanical performance of the neat matrix; at the same time, an increase of surface hydrophilicity was found, with possible positive influence on the biodegradability of such materials after disposal

Validation of multi-physics integrated procedure for the HCPB breeding blanket

The wide range of requirements and constraints involved in the design of nuclear components for fusion reactors makes the development of multi-physics analysis procedures of utmost importance. In the framework of the European DEMO project, the Karlsruhe Institute of Technology (KIT) is dedicating several efforts to the development of a multi-physics analysis tool allowing the characterization of breeding blanket design points which are consistent from the neutronic, thermal-hydraulic and thermal-mechanical points of view. In particular, a procedure developed at KIT is characterized by the implementation of analysis software only. A preliminary step for the validation of such a procedure has been accomplished using a dedicated model of the DEMO Helium Cooled Pebble Bed Blanket 4th outboard module. A global model representative of nuclear irradiation in DEMO and two local models have been set up. Nuclear power deposition and the spatial distribution of its volumetric density have been calculated using Monte Carlo N-Particle transport code for the aforementioned models and compared in order to validate the procedure set up. The outcomes of this comparative study are herein presented and critically discussed