Gender differences in human immunodeficiency virus (HIV) RNA and CD4 cell counts among new entrants to HIV care

ABSTRACTClinic database extraction identified 806 new entrants to human immunodeficiency virus (HIV) care in Cleveland, OH, USA. At entry, women had higherCD4 counts and lower HIVRNAlevels than men (mean, 388 vs. 310 cells/µL, and 8.94 × 104 vs. 1.27 × 105 copies/mL, respectively), but the proportion of entrants with category C illnesses, category B conditions, sexually transmitted diseases and CD4 counts < 200 µL did not differ between genders. Hepatitis B seroprevalence was higher in men (8.7% vs. 0.6%), but there was no difference in hepatitis C prevalence. Whether women in Cleveland seek HIV care earlier, or whether early markers of HIV disease differ between the genders, remains to be determined

Non-nosocomial healthcare-associated infective endocarditis in Taiwan: an underrecognized disease with poor outcome

<p>Abstract</p> <p>Background</p> <p>Non-nosocomial healthcare-associated infective endocarditis (NNHCA-IE) is a new category of IE of increasing importance. This study described the clinical and microbiological characteristics and outcome of NNHCA-IE in Taiwan.</p> <p>Methods</p> <p>A retrospective study was conducted of all patients with IE admitted to the Kaohsiung Veterans General Hospital in Kaohsiung, Taiwan over a five-year period from July 2004 to July 2009. The clinical and microbiological features of NNHCA-IE were compared to those of community-acquired and nosocomial IE. Predictors for in-hospital death were determined.</p> <p>Results</p> <p>Two-hundred episodes of confirmed IE occurred during the study period. These included 148 (74%) community-acquired, 30 (15%) non-nosocomial healthcare-associated, and 22 (11%) nosocomial healthcare-associated IE. <it>Staphylococcus aureus </it>was the most frequent pathogen. Patients with NNHCA-IE compared to community-acquired IE, were older (median age, 67 vs. 44, years, <it>p </it>< 0.001), had more MRSA (43.3% vs. 9.5%, <it>p </it>< 0.001), more comorbidity conditions (median Charlson comorbidity index [interquartile range], 4[2-6] vs. 0[0-1], <it>p </it>< 0.001), a higher in-hospital mortality (50.0% vs. 17.6%, <it>p </it>< 0.001) and were less frequently recognized by clinicians on admission (16.7% vs. 47.7%, <it>p </it>= 0.002). The overall in-hospital mortality rate for all patients with IE was 25%. Shock was the strongest risk factor for in-hospital death (odds ratio 7.8, 95% confidence interval 2.4-25.2, <it>p </it>< 0.001).</p> <p>Conclusions</p> <p>NNHCA-IE is underrecognized and carries a high mortality rate. Early recognition is crucial to provide optimal management and improve outcome.</p

One Hundred Priority Questions for the Development of Sustainable Food Systems in Sub-Saharan Africa

Sub-Saharan Africa is facing an expected doubling of human population and tripling of food demand over the next quarter century, posing a range of severe environmental, political, and socio-economic challenges. In some cases, key Sustainable Development Goals (SDGs) are in direct conflict, raising difficult policy and funding decisions, particularly in relation to trade-offs between food production, social inequality, and ecosystem health. In this study, we used a horizon-scanning approach to identify 100 practical or research-focused questions that, if answered, would have the greatest positive impact on addressing these trade-offs and ensuring future productivity and resilience of food-production systems across sub-Saharan Africa. Through direct canvassing of opinions, we obtained 1339 questions from 331 experts based in 55 countries. We then used online voting and participatory workshops to produce a final list of 100 questions divided into 12 thematic sections spanning topics from gender inequality to technological adoption and climate change. Using data on the background of respondents, we show that perspectives and priorities can vary, but they are largely consistent across different professional and geographical contexts. We hope these questions provide a template for establishing new research directions and prioritising funding decisions in sub-Saharan Africa

Microclimate monitoring of Ariadne's house (Pompeii, Italy) for preventive conservation of fresco paintings

Background: Ariadne's house, located at the city center of ancient Pompeii, is of great archaeological value due to the fresco paintings decorating several rooms. In order to assess the risks for long-term conservation affecting the valuable mural paintings, 26 temperature data-loggers and 26 relative humidity data-loggers were located in four rooms of the house for the monitoring of ambient conditions. Results: Data recorded during 372 days were analyzed by means of graphical descriptive methods and analysis of variance (ANOVA). Results revealed an effect of the roof type and number of walls of the room. Excessive temperatures were observed during the summer in rooms covered with transparent roofs, and corrective actions were taken. Moreover, higher humidity values were recorded by sensors on the floor level. Conclusions: The present work provides guidelines about the type, number, calibration and position of thermohygrometric sensors recommended for the microclimate monitoring of mural paintings in outdoor or semi-confined environments. © 2012 Merello et al.; licensee Chemistry Central Ltd.This work was partially supported by the Spanish Government (Ministerio de Ciencia e Innovacion) under projects HAR2010-21944-C02-01 and HAR2010-21944-C02-02.Merello Giménez, P.; García Diego, FJ.; Zarzo Castelló, M. (2012). Microclimate monitoring of Ariadne's house (Pompeii, Italy) for preventive conservation of fresco paintings. Chemistry Central Journal. 6:145-161. https://doi.org/10.1186/1752-153X-6-145S1451616Ribera A, Olcina M, Ballester C: Pompeya Bajo Pompeya, las Excavaciones en la Casa de Ariadna. Valencia: Fundación MARQ; 2007.World Monuments Fund: World Monuments Watch: 100 Most Endangered Sites. New York: World Monuments Fund; 1996.Anter KF: Colours in Pompeiian cityscape: Adding pieces to the puzzle. Color Res Appl 2006,31(4):331–340.Harris J: Protecting Pompeii and the Italian heritage in 2012. http://www.i-italy.org/bloggers/18935/protecting-pompeii-and-italian-heritage-2012Augusti S: La Tecnica Dell’antica Pittura Parietale Pompeiana. Napoli: Gaetano Macchiaroli Editore; 1950.Miriello D, Barca D, Bloise A, Ciarallo A, Crisci GM, De Rose T, Gattuso C, Gazineo F, La Russa MF: Characterisation of archaeological mortars from Pompeii (Campania, Italy) and identification of construction phases by compositional data analysis. J Arch Sci 2010, 37:2207–2223.Castriota M, Cosco V, Barone T, De Santo G, Carafa P, Cazzanelli E: Micro-Raman characterizations of Pompei’s mortars. J Raman Spectrosc 2008,39(2):295–301.Maguregui M, Knuutinen U, Castro K, Madariaga JM: Raman spectroscopy as a tool to diagnose the impact and conservation state of Pompeian second and fourth style wall paintings exposed to diverse environments (House of Marcus Lucretius). J Raman Spectrosc 2010,41(11):1400–1409.Genestar C, Pons C, Más A: Analytical characterisation of ancient mortars from the archaeological Roman city of Pollentia (Balearic Islands, Spain). Anal Chim Acta 2006, 557:373–379.Duran A, Perez-Maqueda LA, Poyato J, Perez-Rodriguez JL: A thermal study approach to roman age wall painting mortars. J Therm Anal Calorim 2010,99(3):803–809.Pérez MC, García Diego F-J, Merello P, D’Antoni P, Fernández Navajas A, Ribera Lacomba A, Ferrazza L, Pérez Miralles J, Baró JL, Merce P, D’Antoni H, Curiel Esparza J: Ariadne’s house (Pompeii, Italy) wall paintings: a multidisciplinary study of its present state focused on a future restoration and preventive conservation. Mater Constr in pressBernardi A: Microclimate in the British Museum. London. Museum Manag Curat 1990, 9:169–182.Bernardi A, Camuffo D: Microclimate in the Chiericati Palace Municipal Museum. Vicenza. Museum Manag Curat 1995, 14:5–18.Camuffo D, Bernardi A, Sturaro G, Valentino A: The microclimate inside the Pollaiolo and Botticelli rooms in the Uffizi Gallery. Florence. J Cult Herit 2002, 3:155–161.La Gennusa M, Rizzo G, Scaccianoce G, Nicoletti F: Control of indoor environments in heritage buildings: Experimental measurements in an old Italian museum and proposal of a methodology. J Cult Herit 2005,6(2):147–155.Camuffo D, Sturaro G, Valentino A: Thermodynamic exchanges between the external boundary layer and the indoor microclimate at the Basilica of Santa Maria Maggiore, Rome, Italy: the problem of conservation of ancient works of art. Bound Lay Meteorol 1999, 92:243–262.Tabunschikov Y, Brodatch M: Indoor air climate requirements for Russian churches and cathedrals. Indoor Air 2004,14(Suppl 7):168–174.Loupa G, Charpantidou E, Kioutsioukis I, Rapsomanikis S: Indoor microclimate, ozone and nitrogen oxides in two medieval churches in Cyprus. Atmos Environ 2006, 40:7457–7466.Vuerich E, Malaspina F, Barazutti M, Georgiadis T, Nardino M: Indoor measurements of microclimate variables and ozone in the church of San Vincenzo (Monastery of Bassano Romano – Italy): a pilot study. Microchem J 2008, 88:218–223.García-Diego F-J, Zarzo M: Microclimate monitoring by multivariate statistical control: the renaissance frescoes of the cathedral of valencia (Spain). J Cult Herit 2010,11(3):339–344.Zarzo M, Fernández-Navajas A, García-Diego F-J: Long-term monitoring of fresco paintings in the Cathedral of Valencia (Spain) through humidity and temperature sensors in various locations for preventive conservation. Sensors 2011,11(9):8685–8710.Maekawa S, Lambert F, Meyer J: Environmental monitoring at Tiwanaku. Mater Res Soc Symp Proc 1995, 352:885–892.Lillie M, Smith R, Reed J, Inglis R: Southwest Scottish Crannogs: using in situ studies to assess preservation in wetland archaeological contexts. J Archaeol Sci 2008,35(7):1886–1900.Verdecchia F, Zoccatelli C, Norelli E, Miandro R: Integrated monitoring network for surface deformation in Capo Colonna archaeological area, Crotone. Italy. IAHS-AISH P 2010, 339:345–351.Nava S, Becherini F, Bernardi A, Bonazza A, Chiari M, García-Orellana I, Lucarelli F, Ludwig N, Migliori A, Sabbioni C, Udisti R, Valli G, Vecchi R: An integrated approach to assess air pollution threats to cultural heritage in a semi-confined environment: the case study of Michelozzo’s Courtyard in Florence (Italy). Sci Total Environ 2010,408(6):1403–1413.Hygrochron Temperature/Humidity Logger iButton with 8KB Data-Log Memory. Maxim Integrated Products. http://datasheets.maxim-ic.com/en/ds/DS1923.pdfTemperature Logger iButton with 8KB Data-Log Memory. Maxim Integrated Products. http://datasheets.maxim-ic.com/en/ds/DS1922L-DS1922T.pdfVisco G, Plattner SH, Fortini P, Di Giovanni S, Sammartino MP: Microclimate monitoring in the Carcer Tullianum: temporal and spatial correlation and gradients evidenced by multivariate analysis; first campaign. Chem Cent J 2012,6(Suppl 2):S11.UNI 10829: Works of Art of Historical Importance. Ambient Conditions for the Conservation. Measurement and Analysis. Milano: UNI Ente Nazionale Italiano di Unificazione; 1999.DM 10/2001: Atto di Indirizzo sui Criteri Tecnico-scientifici e Sugli Standard di Funzionamento e Sviluppo dei Musei. Ministero per i Beni e le Attività Culturali. Gazzeta Ufficiale della Repubblica Italiana (Official Bulletin of Italian Republica), Rome (Italy); 2001. DL 112/1998 art. 150 comma 6Camuffo D: Microclimate for Cultural Heritage. Amsterdam: Elsevier Science; 1998.ASTM E 104–02: Standard Practice for Maintaining Constant Relative Humidity by Means of Aqueous Solutions. West Conshohocken, PA: ASTM Intl; 2012.Statgraphics Software. http://www.statgraphics.ne

One hundred priority questions for the development of sustainable food systems in sub-Saharan Africa

Sub-Saharan Africa is facing an expected doubling of human population and tripling of food demand over the next quarter century, posing a range of severe environmental, political, and socio-economic challenges. In some cases, key Sustainable Development Goals (SDGs) are in direct conflict, raising difficult policy and funding decisions, particularly in relation to trade-offs between food production, social inequality, and ecosystem health. In this study, we used a horizon-scanning approach to identify 100 practical or research-focused questions that, if answered, would have the greatest positive impact on addressing these trade-offs and ensuring future productivity and resilience of food-production systems across sub-Saharan Africa. Through direct canvassing of opinions, we obtained 1339 questions from 331 experts based in 55 countries. We then used online voting and participatory workshops to produce a final list of 100 questions divided into 12 thematic sections spanning topics from gender inequality to technological adoption and climate change. Using data on the background of respondents, we show that perspectives and priorities can vary, but they are largely consistent across different professional and geographical contexts. We hope these questions provide a template for establishing new research directions and prioritising funding decisions in sub-Saharan Africa

The Interplay between Air Quality and Energy Efficiency in Museums, a Review

Data Availability Statement: No new data were created or analyzed in this study. Data sharing is not applicable to this article.Energy efficiency in museums and buildings that house works of art or cultural heritage appears to be a difficult achievement if indoor air quality has to be kept at appropriate levels for artefacts’ long-term sustainability. There is a gap in our scientific literature on the relationship between indoor air quality and energy efficiency, meaning that there are no numerical data that examine both of them simultaneously, although this is a theme that is broadly discussed by museum managers, curators, and scientists. It is certain that the two parameters, indoor air quality (IAQ) and energy efficiency (EEF) are conflicting and difficult to reconcile. Furthermore, IAQ is not only the determination of temperature, relative humidity, and CO2, as is usually presented. Using green or renewable energy does not make a building “energy efficient”. Hence, in the manuscript we review the literature on IAQ of museums and exhibition buildings, in conjunction with the consideration of their EEF. Hopefully, reviewing the literature for this problem may lead to carefully designed monitoring experiments. The selection, application, and testing of appropriate technological measures can lead to a new balance between the two conflicting parameters. Not only must solutions be found, but these solutions are necessary in the mitigation battle against climate change.This research received no external funding