High-efficiency degenerate four wave-mixing in triply resonant nanobeam cavities

We demonstrate high-efficiency, degenerate four-wave mixing in triply resonant Kerr $\chi^(3)$ photonic crystal (PhC) nanobeam cavities. Using a combination of temporal coupled mode theory and nonlinear finite-difference time-domain (FDTD) simulations, we study the nonlinear dynamics of resonant four-wave mixing processes and demonstrate the possibility of observing high-efficiency limit cycles and steady-state conversion corresponding to $\approx 100$% depletion of the pump light at low powers, even including effects due to losses, self- and cross-phase modulation, and imperfect frequency matching. Assuming operation in the telecom range, we predict close to perfect quantum efficiencies at reasonably low $\sim$ 50 mW input powers in silicon micrometer-scale cavities

Classical and fluctuation-induced electromagnetic interactions in micronscale systems: designer bonding, antibonding, and Casimir forces

Whether intentionally introduced to exert control over particles and macroscopic objects, such as for trapping or cooling, or whether arising from the quantum and thermal fluctuations of charges in otherwise neutral bodies, leading to unwanted stiction between nearby mechanical parts, electromagnetic interactions play a fundamental role in many naturally occurring processes and technologies. In this review, we survey recent progress in the understanding and experimental observation of optomechanical and quantum-fluctuation forces. Although both of these effects arise from exchange of electromagnetic momentum, their dramatically different origins, involving either real or virtual photons, lead to different physical manifestations and design principles. Specifically, we describe recent predictions and measurements of attractive and repulsive optomechanical forces, based on the bonding and antibonding interactions of evanescent waves, as well as predictions of modified and even repulsive Casimir forces between nanostructured bodies. Finally, we discuss the potential impact and interplay of these forces in emerging experimental regimes of micromechanical devices.Comment: Review to appear on the topical issue "Quantum and Hybrid Mechanical Systems" in Annalen der Physi

Designing evanescent optical interactions to control the expression of Casimir forces in optomechanical structures

We propose an optomechanical structure consisting of a photonic-crystal (holey) membrane suspended above a layered silicon-on-insulator substrate in which resonant bonding/antibonding optical forces created by externally incident light from above enable all-optical control and actuation of stiction effects induced by the Casimir force. In this way, one can control how the Casimir force is expressed in the mechanical dynamics of the membrane, not by changing the Casimir force directly but by optically modifying the geometry and counteracting the mechanical spring constant to bring the system in or out of regimes where Casimir physics dominate. The same optical response (reflection spectrum) of the membrane to the incident light can be exploited to accurately measure the effects of the Casimir force on the equilibrium separation of the membrane

Assessment of Cardiorespiratory Interactions During Spontaneous and Controlled Breathing: Non-linear Model-free Analysis

In this work, nonlinear model-free methods for bivariate time series analysis have been applied to study cardiorespiratory interactions. Specifically, entropy-based (i.e. Transfer Entropy and Cross Entropy) and Convergent Cross Mapping asymmetric coupling measures have been computed on heart rate and breathing time series extracted from electrocardiographic (ECG) and respiratory signals acquired on 19 young healthy subjects during an experimental protocol including spontaneous and controlled breathing conditions. Results evidence a bidirectional nature of cardiorespiratory interactions, and highlight clear similarities and differences among the three considered measures

Control of buckling in large micromembranes using engineered support structures

In this paper we describe a general method to avoid stress-induced buckling of thin and large freestanding membranes. We show that using properly designed supports, in the form of microbeams, we can reduce the out-of-plane deflection of the membrane while maintaining its stiffness. As a proof of principle, we used a silicon-on-insulator (SOI) platform to fabricate 30 µm wide, 220 nm thick, free-standing Si membranes, supported by four 15 µm long and 3 µm wide microbeams. Using our approach, we are able to achieve an out-of-plane deformation of the membrane smaller than 50 nm in spite of 39 MPa of compressive internal stress. Our method is general, and can be applied to different material systems with compressive or tensile internal stress.United States. Defense Advanced Research Projects Agency. (Contract N66001-09-1-2070-DOD

Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity

Our research, inspired by the pioneering works of Isaac Witz in the 1980s, established that 40% of human metastatic melanomas express ectopically inhibitory Fc gamma receptors (FcγRIIB), while they are detected on less than 5% of primary cutaneous melanoma and not on melanocytes. We demonstrated that these tumoral FcγRIIB act as decoy receptors that bind the Fc portion of antimelanoma IgG, which may prevent Fc recognition by the effector cells of the immune system and allow the metastatic melanoma to escape the humoral/natural immune response. The FcγRIIB is able to inhibit the ADCC (antibody dependent cell cytotoxicity) in vitro. Interestingly, the percentage of melanoma expressing the FcγRIIB is high (70%) in organs like the liver, which is rich in patrolling NK (natural killer) cells that exercise their antitumoral activity by ADCC. We found that this tumoral FcγRIIB is fully functional and that its inhibitory potential can be triggered depending on the specificity of the anti-tumor antibody with which it interacts. Together these observations elucidate how metastatic melanomas interact with and potentially evade humoral immunity and provide direction for the improvement of anti-melanoma monoclonal antibody therapy

Improved understanding of dynamic water and mass budgets of high‐alpine karst systems obtained from studying a well‐defined catchment area

Large areas of Europe, especially in the Alps, are covered by carbonate rocks and in many alpine regions, karst springs are important sources for drinking water supply. Because of their high variability and heterogeneity, the understanding of the hydrogeological functioning of karst aquifers is of particular importance for their protection and utilisation. Climate change and heavy rainfall events are major challenges in managing alpine karst aquifers which possess an enormous potential for future drinking water supply. In this study, we present research from a high‐alpine karst system in the UNESCO Biosphere Reserve Großes Walsertal in Austria, which has a clearly defined catchment and is drained by only one spring system. Results show that (a) the investigated system is a highly dynamic karst aquifer with distinct reactions to rainfall events in discharge and electrical conductivity; (b) the estimated transient atmospheric CO2 sink is about 270 t/a; (c) the calculated carbonate rock denudation rate is between 23 and 47 mm/1000a and (d) the rainfall‐discharge behaviour and the internal flow dynamics can be successfully simulated using the modelling package KarstMod. The modelling results indicate the relevance of matrix storage in determining the discharge behaviour of the spring, particularly during low‐flow periods. This research and the consequent results can contribute and initiate a better understanding and management of alpine karst aquifers considering climate change with more heavy rainfall events and also longer dry periods.The investigated karst system contributes to the transient atmospheric CO2 sink with about 270 t/a. Carbonate denudation rates vary between 23 and 47 mm/1000a. Rainfall‐discharge modelling results indicate the importance of matrix storage particularly during low‐flow periods. imageBundesministerium für Bildung und Forschung http://dx.doi.org/10.13039/501100002347FP7 People: Marie‐Curie Actions http://dx.doi.org/10.13039/10001126

Optomechanical and photothermal interactions in suspended photonic crystal membranes

We present here an optomechanical system fabricated with novel stress management techniques that allow us to suspend an ultrathin defect-free silicon photonic-crystal membrane above a Silicon-on-Insulator (SOI) substrate with a gap that is tunable to below 200 nm. Our devices are able to generate strong attractive and repulsive optical forces over a large surface area with simple in- and out- coupling and feature the strongest repulsive optomechanical coupling in any geometry to date (g[subscript OM]/2π ≈ −65 GHz/nm). The interplay between the optomechanical and photo-thermal-mechanical dynamics is explored, and the latter is used to achieve cooling and amplification of the mechanical mode, demonstrating that our platform is well-suited for potential applications in low-power mass, force, and refractive-index sensing as well as optomechanical accelerometry.United States. Defense Advanced Research Projects Agency. (Contract N66001-09-1-2070-DOD)National Science Foundation (U.S.) (CAREER Grant