Can an evolutionary perspective shed light on maternal abuse of children?

Although the theory of evolution lies at the heart of contemporary biology, its influence on the study of child psychology and psychiatry has been limited. In earlier work we have argued that evolutionary thinking has much of value for clinicians. Here, we explore the possible significance of evolutionary theory for understanding child abuse by mothers, particularly neglect, emotional abuse and physical abuse. We draw on the research of anthropologists, primatologists and evolutionary theorists to make predictions about the environmental circumstances under which one would expect such abuse to be more prevalent. We discuss how in modern, Western cultures there is less understanding of the circumstances that may influence, even predispose, a mother to limit her emotional and material commitment to an infant or child. We use four short vignettes of clinical cases and one longer case description to illustrate the insights offered to clinicians by an evolutionary approach. We see our work both as contributing to greater understanding of these matters and as facilitating more compassionate models of care and intervention for women in such circumstances

Constraints on QCD Sum-rules from the H\"older Inequalities

A new technique based on H\"older's integral inequality is applied to QCD sum-rules to provide fundamental constraints on the sum-rule parameters. These constraints must be satisfied if the sum-rules are to consistently describe integrated physical cross-sections, but these constraints do not require any experimental data and therefore can be applied to any hadronic spectral function. As an illustration of this technique the Laplace sum-rules of the light-quark correlation function for the vector and the axial-vector currents are examined in detail. We find examples of inconsistency between the inequalities and sum-rule parameters used in some previous analyses of the vector and axial-vector channels.Comment: 13 pages, RevTeX, 4 figures available upon request, to appear in Phys. Lett

Chiral condensates from tau decay: a critical reappraisal

The saturation of QCD chiral sum rules is reanalyzed in view of the new and complete analysis of the ALEPH experimental data on the difference between vector and axial-vector correlators (V-A). Ordinary finite energy sum rules (FESR) exhibit poor saturation up to energies below the tau-lepton mass. A remarkable improvement is achieved by introducing pinched, as well as minimizing polynomial integral kernels. Both methods are used to determine the dimension d=6 and d=8 vacuum condensates in the Operator Product Expansion, with the results: {O}_{6}=-(0.00226 \pm 0.00055) GeV^6, and O_8=-(0.0053 \pm 0.0033) GeV^8 from pinched FESR, and compatible values from the minimizing polynomial FESR. Some higher dimensional condensates are also determined, although we argue against extending the analysis beyond dimension d = 8. The value of the finite remainder of the (V-A) correlator at zero momentum is also redetermined: \Pi (0)= -4 \bar{L}_{10}=0.02579 \pm 0.00023. The stability and precision of the predictions are significantly improved compared to earlier calculations using the old ALEPH data. Finally, the role and limits of applicability of the Operator Product Expansion in this channel are clarified.Comment: Replaced versio

How evolutionary thinking can help us to understand ADHD

We argue that current debates about attention-deficit hyperactivity disorder (ADHD) can be considered afresh using an evolutionary lens. We show how the symptoms of ADHD can often be considered adaptive to their specific environment. We suggest that, from an evolutionary point of view, ADHD symptoms might be understood to result from an ‘evolutionary mismatch’, in which current environmental demands do not fit with what evolution has prepared us to cope with. For example, in our ancestral environment of evolutionary adaptedness (EEA), children were not expected to sit still and concentrate on academic tasks for many hours a day. Understanding ADHD in terms of such a ‘mismatch’ raises significant issues regarding the management of childhood ADHD, including ethical ones. An approach based on the concept of mismatch could provide an alternative to current debates on whether ADHD results from nature or nurture and whether it is under- or over-diagnosed. It would allow clinicians and policy makers to take both the child and the environment into account and consider what might be desirable and feasible, both in society and for specific children, to lessen the mismatch

The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: Common diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of body mass index (BMI), waist circumference and fat percent (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels. METHODS: The first 2296 participants (mean age 76+/-6 years, 42% men) in the Age, Gene/Environment Susceptibility-Reykjavik Study, a multidisciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 single nucleotide polymorphisms (SNPs) in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference and percent fat were used to evaluate the association of genotypes to CRP levels (high-sensitivity method, range 0-10 mg l(-1)) in men and women separately. RESULTS: We focused on the SNP rs1205 that represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than noncarriers in a dose-dependent manner. Compared to the AA genotype, the slope of the increase in CRP with increasing BMI (P=0.045) and waist circumference (P=0.014) was different for the G allele carriers and of similar magnitude in both men and women. The rs1205 interactions were not significant for fat mass percent, suggesting a possible association with fat localization. CONCLUSIONS: This study further illuminates the known association between measures of adiposity and CRP levels and is shown to be dependent on variation in the rs1205 SNP of the CRP gene. The correlated increase in CRP levels with adiposity is accentuated by presence of the G allele

The Off Shell ρ\rho-ω\omega Mixing in the QCD Sum Rules

The $q^2$ dependence of the $\rho-\omega$ mixing amplitude is analyzed with the use of the QCD sum rules and the dispersion relation. Going off shell the mixing decreases, changes sign at $q^2 \simeq 0.4 m_{\rho}^2 > 0$ and is negative in the space like region. Implications of this result to the isospin breaking part of the nuclear force are discussed.Comment: 26 pages + 11 figures (PostScript

Pseudoscalar Glueball Mass: QCD vs. Lattice Gauge Theory Prediction

We study whether the pseudoscalar glueball mass in full QCD can differ from the prediction of quenched lattice calculations. Using properties of the correlator of the vacuum topological susceptibility we derive an expression for the upper bound on the QCD glueball mass. We show that the QCD pseudoscalar glueball is lighter than the pure Yang-Mills theory glueball studied in quenched lattice calculations. The mass difference between those two states is of order of $1/N_c$. The value calculated for the $0^{-+}$ QCD glueball mass can not be reconciled with any physical state observed so far in the corresponding channel. The glueball decay constant and its production rate in $J/\psi$ radiative decays are calculated. The production rate is large enough to be studied experimentally.Comment: 18 pages, LaTex fil

Calculation of gluon and four-quark condensates from the operator expansion

The magnitudes of gluon and four-quark condensates are found from the analysis of vector mesons consisting of light quarks (the families of $\rho$ and $\omega$ mesons) in the 3 loops approximation. The QCD model with infinite number of vector mesons is used to describe the function $R(s)$. This model describes well the experimental function $R(s)$. Polarization operators calculated with this model coincide with the Wilson operator expansion at large $Q^2$. The improved perturbative theory, such that the polarization operators have correct analytical properties, is used. The result is $<0 | (\alpha_s/\pi) G^2 | 0 > = 0.062 \pm 0.019 GeV^4$. The electronic widths of $\rho(1450)$ and $\omega(1420)$ are calculated.Comment: 18 pages, latex, changed content slightl

Retinopathy in old persons with and without diabetes mellitus: the Age, Gene/Environment Susceptibility--Reykjavik Study (AGES-R).

To access full text version of this article. Please click on the hyperlink "View/open" at the bottom of this pageWe aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus was defined as HbA(1c) ≥ 6.5% (>48 mmol/mol). Retinopathy was assessed by grading fundus photographs using the modified Airlie House adaptation of the Early Treatment Diabetic Retinopathy Study protocol. Associations between retinopathy and risk factors were estimated using odds ratios obtained from multivariate analyses. The overall prevalence of retinopathy in AGES-R was 12.4%. Diabetes mellitus was present in 516 persons (10.3%), for 512 of whom gradable fundus photos were available, including 138 persons (27.0%, 95% CI 23.2, 31.0) with any retinopathy. Five persons (1.0%, 95% CI 0.3, 2.3) had proliferative retinopathy. Clinically significant macular oedema was present in five persons (1.0%, 95% CI 0.3, 2.3). Independent risk factors for retinopathy in diabetic patients in a multivariate model included HbA(1c), insulin use and use of oral hypoglycaemic agents, the last two being indicators of longer disease duration. In 4478 participants without diabetes mellitus, gradable fundus photos were available for 4,453 participants, with retinopathy present in 476 (10.7%, 95% CI 9.8, 11.6) and clinically significant macular oedema in three persons. Independent risk factors included increasing age and microalbuminuria. Over three-quarters (78%) of retinopathy cases were found in persons without diabetes and a strong association between microalbuminuria and non-diabetic retinopathy was found. These results may have implications for patient management of the aged.NIH N01-AG-12100 NIH/NIA, National Eye Institute (NEI) of the NIH ZIAEY000401, Hjartavernd (the Icelandic Heart Association), Althingi (the Icelandic Parliament), University of Iceland