Structure analysis of proteins, peptides and metal complexes by vibrational circular dichroism

There are two principal forms of vibrational optical activity (VOA), an IR form referred to as vibrational circular dichroism (VCD) and Raman form known as Raman optical activity (ROA). This paper reports examples of the application of VCD spectroscopy for the determination of the absolute configuration and conformation of chiral molecules, e. g. cyclic beta-lactams. VCD spectroscopy can be applied for the characterization of the conformation of proteins and peptides in solution. VCD based conformational analysis of cyclic peptides is discussed. Examples are the cyclic hexapeptide cyclo(Pro(2)-Gly-Pro(2)-Gly) and cyclic peptides comprising beta-homoamino acids (trans-2-aminocyclopentane or trans-2-aminocyclohexane carboxylic acid). Structure analysis by VCD of opiate peptides, glycopeptides, peptidomimetics and chiral transition metal complexes are also discussed

High Resolution Heavy Ion Track Structure Imaging

The difference in the relative biological efficincy (RBE) of ions of same linear energy transfer (LET) but different atomic number (Z) can be attributed to the difference in the radial ionisation distribution. In this contribution we present data from measurements of the spatial ionisation pattern of heavy ions of various Z but similar LET and compare the results with track structure data obtained by Monte Carlo simulations. The measurements were made with a time projection chamber with optical readout (Optical Avalanche Chamber, OPAC) which is able to quantitatively capture the spatial ionisation pattern of an ion traversing the chambe

Detectors for Energy-Resolved Fast Neutron Imaging

Two detectors for energy-resolved fast-neutron imaging in pulsed broad-energy neutron beams are presented. The first one is a neutron-counting detector based on a solid neutron converter coupled to a gaseous electron multiplier (GEM). The second is an integrating imaging technique, based on a scintillator for neutron conversion and an optical imaging system with fast framing capability

Environmental changes and violent conflict

This letter reviews the scientific literature on whether and how environmental changes affect the risk of violent conflict. The available evidence from qualitative case studies indicates that environmental stress can contribute to violent conflict in some specific cases. Results from quantitative large-N studies, however, strongly suggest that we should be careful in drawing general conclusions. Those large-N studies that we regard as the most sophisticated ones obtain results that are not robust to alternative model specifications and, thus, have been debated. This suggests that environmental changes may, under specific circumstances, increase the risk of violent conflict, but not necessarily in a systematic way and unconditionally. Hence there is, to date, no scientific consensus on the impact of environmental changes on violent conflict. This letter also highlights the most important challenges for further research on the subject. One of the key issues is that the effects of environmental changes on violent conflict are likely to be contingent on a set of economic and political conditions that determine adaptation capacity. In the authors' view, the most important indirect effects are likely to lead from environmental changes via economic performance and migration to violent conflict. © 2012 IOP Publishing Ltd

Missing Migrants in the Mediterranean : Addressing the Humanitarian Crisis Summary report

The Mediterranean Missing research project has sought to understand both the impact on families of having a relative missing in migration, and the law, policy and practice around the identification of bodies of dead migrants in Italy and Greece. Interviews with families of missing migrants from five countries confirmed the huge impact of not knowing the fate of loved ones, with families tortured by ambiguity and suffering a range of emotional and psychological consequences. In Lesbos, Greece, and Sicily, Italy, interviews with authorities, civil society and others confirm the presence of a policy vacuum around the issue of the missing, despite the duties on states imposed by human rights law. Investigation of deaths is inadequate, with effective post-mortem data collection and management challenged by the huge numbers of migrants , in some cases sufficiently to compromise future identification. In both Greece and Italy, response is characterised by a policy vacuum, with a large number of agencies with overlapping mandates lacking coordination. Whilst in Italy a dedicated Commission and its partners have demonstrated what can be done with appropriate resources, there is a need to ensure that all the dead benefit from such an approach. A constraint in both contexts remains the lack of outreach to families of the missing, who can provide ante-mortem data to enable identification, and who should anyway be at the centre of all efforts to address the issue and identify the dead