Combined frequency-amplitude nonlinear modulation: theory and applications

In this work we formulate a generalized theoretical model to describe the nonlinear dynamics observed in combined frequency-amplitude modulators whose characteristic parameters exhibit a nonlinear dependence on the input modulating signal. The derived analytical solution may give a satisfactory explanation of recent laboratory observations on magnetic spin-transfer oscillators and fully agrees with results of micromagnetic calculations. Since the theory has been developed independently of the mechanism causing the nonlinearities, it may encompass the description of modulation processes of any physical nature, a promising feature for potential applications in the field of communication systems.Comment: 8 pages, 4 figures, to be published on IEEE Transactions on Magnetic

Noise Induced Phenomena in the Dynamics of Two Competing Species

Noise through its interaction with the nonlinearity of the living systems can give rise to counter-intuitive phenomena. In this paper we shortly review noise induced effects in different ecosystems, in which two populations compete for the same resources. We also present new results on spatial patterns of two populations, while modeling real distributions of anchovies and sardines. The transient dynamics of these ecosystems are analyzed through generalized Lotka-Volterra equations in the presence of multiplicative noise, which models the interaction between the species and the environment. We find noise induced phenomena such as quasi-deterministic oscillations, stochastic resonance, noise delayed extinction, and noise induced pattern formation. In addition, our theoretical results are validated with experimental findings. Specifically the results, obtained by a coupled map lattice model, well reproduce the spatial distributions of anchovies and sardines, observed in a marine ecosystem. Moreover, the experimental dynamical behavior of two competing bacterial populations in a meat product and the probability distribution at long times of one of them are well reproduced by a stochastic microbial predictive model.Comment: 23 pages, 8 figures; to be published in Math. Model. Nat. Phenom. (2016

Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action

Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the patients. Indeed, except for most of the immunotherapeutic agents, the complete lack of selectivity between normal and cancer cells for radio- and chemotherapy can make them potential antagonists of the host anti-cancer self-defense over time. Recently, the use of nutraceuticals as natural compounds corroborating anti-cancer standard therapy is emerging as a promising tool for their relative abundance, bioavailability, safety, low-cost effectiveness, and immuno-compatibility with the host. In this review, we outlined the anti-cancer properties of Lactoferrin (Lf), an iron-binding glycoprotein of the innate immune defense. Lf shows high bioavailability after oral administration, high selectivity toward cancer cells, and a wide range of molecular targets controlling tumor proliferation, survival, migration, invasion, and metastasization. Of note, Lf is able to promote or inhibit cell proliferation and migration depending on whether it acts upon normal or cancerous cells, respectively. Importantly, Lf administration is highly tolerated and does not present significant adverse effects. Moreover, Lf can prevent development or inhibit cancer growth by boosting adaptive immune response. Finally, Lf was recently found to be an ideal carrier for chemotherapeutics, even for the treatment of brain tumors due to its ability to cross the blood-brain barrier, thus globally appearing as a promising tool for cancer prevention and treatment, especially in combination therapies

On the conceptual design of the novel balanced rolling piston expander

This work presents a novel type of positive-displacement expander, named the balanced rolling piston expander. It proposes also a design procedure and assesses the mechanical behavior of a virtual prototype. The expander is conceptually capable of operating at higher fluid temperatures than other positive-displacement expanders, such as scroll- or screw-type machines. Moreover, it employs a radially balanced rotor, differently from common rolling piston technologies and does not require any timing mechanism for filling and emptying the working chambers, differently from Wankel or reciprocating solutions. The investigated virtual prototype is chosen for the study case of a small-scale heat recovery unit currently under investigation. The results indicate that a prototype of about 300 mm in diameter and 100 mm in length is capable of an ideal power of 20 kW. Moreover, vane accelerations can be relatively high but anyhow comparable to those in sliding vane machines, while pressure drops in percent terms are in general lower than 1%. Lastly, load-induced displacements are manageable by a proper radial clearance at room temperature. In brief, the balanced rolling piston expander is a promising option for small-scale power generation units operating with temperatures not achievable by common technologies and, hence, it deserves further investigation

Explosion of a massive, He-rich star at z=0.16

We present spectroscopic and photometric data of the peculiar SN 2001gh, discovered by the 'Southern inTermediate Redshift ESO Supernova Search' (STRESS) at a redshift z=0.16. SN 2001gh has relatively high luminosity at maximum (M_B = -18.55 mag), while the light curve shows a broad peak. An early-time spectrum shows an almost featureless, blue continuum with a few weak and shallow P-Cygni lines that we attribute to HeI. HeI lines remain the only spectral features visible in a subsequent spectrum, obtained one month later. A remarkable property of SN 2001gh is the lack of significant spectral evolution over the temporal window of nearly one month separating the two spectra. In order to explain the properties of SN 2001gh, three powering mechanism are explored, including radioactive decays of a moderately large amount of 56Ni, magnetar spin-down, and interaction of SN ejecta with circumstellar medium. We favour the latter scenario, with a SN Ib wrapped in a dense, circumstellar shell. The fact that no models provide an excellent fit with observations, confirms the troublesome interpretation of the nature of SN 2001gh. A rate estimate for SN 2001gh-like event is also provided, confirming the intrinsic rarity of these objects.Comment: 11 pages, 8 figures, 3 tables. Accepted by MNRA

Spectropolarimetry of the Classical T Tauri Star TW Hydrae

We present high resolution (R ~ 60,000) circular spectropolarimetry of the classical T Tauri star TW Hydrae. We analyze 12 photospheric absorption lines and measure the net longitudinal magnetic field for 6 consecutive nights. While no net polarization is detected the first five nights, a significant photospheric field of Bz = 149 \pm 33 G is found on the sixth night. To rule out spurious instrumental polarization, we apply the same analysis technique to several non-magnetic telluric lines, detecting no significant polarization. We further demonstrate the reality of this field detection by showing that the splitting between right and left polarized components in these 12 photospheric lines shows a linear trend with Lande g-factor times wavelength squared, as predicted by the Zeeman effect. However, this longitudinal field detection is still much lower than that which would result if a pure dipole magnetic geometry is responsible for the mean magnetic field strength of 2.6 kG previously reported for TW Hya. We also detect strong circular polarization in the He I 5876 and the Ca II 8498 emission lines, indicating a strong field in the line formation region of these features. The polarization of the Ca II line is substantially weaker than that of the He I line, which we interpret as due to a larger contribution to the Ca II line from chromospheric emission in which the polarization signals cancel. However, the presence of polarization in the Ca II line indicates that accretion shocks on Classical T Tauri stars do produce narrow emission features in the infrared triplet lines of Calcium.Comment: One tar file. The paper has 22 pages, 5 figures. Accepted by AJ on Sep 10, 200

A chemotaxonomic investigation on Vitis vinifera L. 3. Characterization of Vitis biotypes via root apex proteins

Soluble proteins from root tips were used as biochemical markers to study, taxonomically and systematically, Vitis biotypes. Analyses of total proteins in the pH range 3.5-10 and of the enzymes AcP, ADH, EST, PGM and POD indicate that only in the case of proteins and AcP the staining intensity of all samples and the variation of band pattern is taxonomically informative. A comparison between seed storage proteins and root tip proteins and an automatic data acquisition system is included

Probing the Galactic Bulge with deep Adaptive Optics imaging: the age of NGC 6440

We present first results of a pilot project aimed at exploiting the potentiality of ground based adaptive optics imaging in the near infrared to determine the age of stellar clusters in the Galactic Bulge. We have used a combination of high resolution adaptive optics (ESO-VLT NAOS-CONICA) and wide-field (ESO-NTT-SOFI) photometry of the metal rich globular cluster NGC 6440 located towards the inner Bulge, to compute a deep color magnitude diagram from the tip of the Red Giant Branch down to J~22$, two magnitudes below the Main Sequence Turn Off (TO). The magnitude difference between the TO level and the red Horizontal Branch has been used as an age indicator. It is the first time that such a measurement for a bulge globular cluster has been obtained with a ground based telescope. From a direct comparison with 47 Tuc and with a set of theoretical isochrones, we concluded that NGC 6440 is old and likely coeval to 47 Tuc. This result adds a new evidence that the Galactic Bulge is ~2 Gyr younger at most than the pristine, metal poor population of the Galactic Halo

Strategies of tailored nanomaterials for electrochemiluminescence signal enhancements

Nanomaterials and their applications were studied extensively over the past few decades due to their properties which are associated mainly with the nanoscale sizes and unique characteristics that they have. Among many applications, these nanomaterials have been playing great, multifaceted roles in increasing the analytical performances of electrochemiluminescence (ECL). In this article, we review the main possible approaches – based on nanoparticles – to modify the photophysical properties of the excited state generated as a consequence of the electrochemical stimulus and in particular taking profit of the so-called metal-enhanced fluorescence (MEF) and resonance energy transfer (RET) processes. We believe that these strategies will lead to the design of very efficient systems that can substantially increase the possible successful applications of ECL

A Surprising Reversal of Temperatures in the Brown-Dwarf Eclipsing Binary 2MASS J05352184-0546085

The newly discovered brown-dwarf eclipsing binary 2MASS J05352184-0546085 provides a unique laboratory for testing the predictions of theoretical models of brown-dwarf formation and evolution. The finding that the lower-mass brown dwarf in this system is hotter than its higher-mass companion represents a challenge to brown-dwarf evolutionary models, none of which predict this behavior. Here we present updated determinations of the basic physical properties of 2M0535-05, bolstering the surprising reversal of temperatures with mass in this system. We compare these measurements with widely used brown-dwarf evolutionary tracks, and find that the temperature reversal can be explained by some models if the components of 2M0535-05 are mildly non-coeval, possibly consistent with dynamical simulations of brown-dwarf formation. Alternatively, a strong magnetic field on the higher-mass brown dwarf might explain its anomalously low surface temperature, consistent with emerging evidence that convection is suppressed in magnetically active, low-mass stars. Finally, we discuss future observational and theoretical work needed to further characterize and understand this benchmark system.Comment: 31 pages, 7 figures, accepted by Ap