Role of the intercalated disc in cardiac propagation and arrhythmogenesis

This review article discusses mechanisms underlying impulse propagation in cardiac muscle with specific emphasis on the role of the cardiac cell-to-cell junction, called the “intercalated disc.”The first part of this review deals with the role of gap junction channels, formed by connexin proteins, as a determinant of impulse propagation. It is shown that, depending on the underlying structure of the cellular network, decreasing the conductance of gap junction channels (so-called “electrical uncoupling”) may either only slow, or additionally stabilize propagation and reverse unidirectional propagation block to bidirectional propagation. This is because the safety factor for propagation increases with decreasing intercellular electrical conductance. The role of heterogeneous connexin expression, which may be present in disease states, is also discussed. The hypothesis that so-called ephaptic impulse transmission plays a role in heart and can substitute for electrical coupling has been revived recently. Whereas ephaptic transmission can be demonstrated in theoretical simulations, direct experimental evidence has not yet been presented. The second part of this review deals with the interaction of three protein complexes at the intercalated disc: (1) desmosomal and adherens junction proteins, (2) ion channel proteins, and (3) gap junction channels consisting of connexins. Recent work has revealed multiple interactions between these three protein complexes which occur, at least in part, at the level of protein trafficking. Such interactions are likely to play an important role in the pathogenesis of arrhythmogenic cardiomyopathy, and may reveal new therapeutic concepts and targets

Music in Research and Rehabilitation of Disorders of Consciousness: Psychological and Neurophysiological Foundations

According to a prevailing view, the visual system works by dissecting stimuli into primitives, whereas the auditory system processes simple and complex stimuli with their corresponding features in parallel. This makes musical stimulation particularly suitable for patients with disorders of consciousness (DoC), because the processing pathways related to complex stimulus features can be preserved even when those related to simple features are no longer available. An additional factor speaking in favor of musical stimulation in DoC is the low efficiency of visual stimulation due to prevalent maladies of vision or gaze fixation in DoC patients. Hearing disorders, in contrast, are much less frequent in DoC, which allows us to use auditory stimulation at various levels of complexity. The current paper overviews empirical data concerning the four main domains of brain functioning in DoC patients that musical stimulation can address: perception (e.g., pitch, timbre, and harmony), cognition (e.g., musical syntax and meaning), emotions, and motor functions. Music can approach basic levels of patients’ self-consciousness, which may even exist when all higher-level cognitions are lost, whereas music induced emotions and rhythmic stimulation can affect the dopaminergic reward-system and activity in the motor system respectively, thus serving as a starting point for rehabilitation

Bilinear identities on Schur symmetric functions

A series of bilinear identities on the Schur symmetric functions is obtained with the use of Pluecker relations.Comment: Accepted to Journal of Nonlinear Mathematical Physics. A reference to a connected result is adde

Quantum matter wave dynamics with moving mirrors

When a stationary reflecting wall acting as a perfect mirror for an atomic beam with well defined incident velocity is suddenly removed, the density profile develops during the time evolution an oscillatory pattern known as diffraction in time. The interference fringes are suppressed or their visibility is diminished by several effects such as averaging over a distribution of incident velocities, apodization of the aperture function, atom-atom interactions, imperfect reflection or environmental noise. However, when the mirror moves with finite velocity along the direction of propagation of the beam, the visibility of the fringes is enhanced. For mirror velocities below beam velocity, as used for slowing down the beam, the matter wave splits into three regions separated by space-time points with classical analogues. For mirror velocities above beam velocity a visibility enhancement occurs without a classical counterpart. When the velocity of the beam approaches that of the mirror the density oscillations rise by a factor 1.8 over the stationary value.Comment: 5.2 pages, 6 figure

Magnetic edge states of impenetrable stripe

The electron motion in a strong perpendicular magnetic field close to the impenetrable stripe is considered by making use of the singular integral equation technique. The energy spectrum is calculated and compared with the energy spectrum of the round antidot.Comment: REVTeX4 format, 9 pages with 9 figures (*.eps

Qualitative Assessment of General Aviation Pilots’ Perceptions of Preflight Weather Briefings

Prior to departing on a flight, General Aviation pilots complete a pre-flight planning process to ensure the safety of their flight. One aspect of the pre-flight planning process is obtaining a briefing on the weather conditions that the pilot might encounter along their flight route. Traditionally pilots have utilized a phone-in service run by Flight Services to aid in their assessment of weather conditions. However, research indicates that pilots are increasingly reliant on conducting self- briefing using online resources. The purpose of this study is to determine pilot perceptions of obtaining a phone-in brief in comparison to self-briefing

Transient tunneling effects of resonance doublets in triple barrier systems

Transient tunneling effects in triple barrier systems are investigated by considering a time-dependent solution to the Schr\"{o}dinger equation with a cutoff wave initial condition. We derive a two-level formula for incidence energies $E$ near the first resonance doublet of the system. Based on that expression we find that the probability density along the internal region of the potential, is governed by three oscillation frequencies: one of them refers to the well known Bohr frequency, given in terms of the first and second resonance energies of the doublet, and the two others, represent a coupling with the incidence energy $E$. This allows to manipulate the above frequencies to control the tunneling transient behavior of the probability density in the short-time regim

Customer service orientation on adhesion contracts

Hiring a service is a moment of great importance once it builds the perception of the service value and quality. Some companies may deal with that, assuming a greater importance when elaborating their service contracts. Usually law professional people elaborate these documents, but this may include legal attributes, not considering the service to the customers, as well as the customers’ point of view. In times of increasing on customer focus, market and service orientation, a question can be posted: to what extent company contracts show service or customer orientation? This paper compares the service orientation degree for Cable TV contracts from five companies, based on a theoretical model developed to this purpose. From a conceptual model for servant contract, four dimensions were assessed: physical aspects, reasonableness, intelligibility and customer focus. After subject evaluation by eight judges, analyzing the validation index (CVI), it was found that the contracts show moderate orientation to serve. Furthermore, results show that the five surveyed company’s contracts showed a similar overall performance, i.e., none stood out over the other. The study presents important practical efficacy, because it can guide the Cable TV companies to adopt improvement strategies in elaboration of contracts, so that the contractual instruments be would reviewed of clauses that promote the sensation of better service to their customer. Thus, this article directs the manager to the aspect that deserves more attention, i.e, which dimensions require further refinement and direction to serv

Strong Spherical Asymptotics for Rotor-Router Aggregation and the Divisible Sandpile

The rotor-router model is a deterministic analogue of random walk. It can be used to define a deterministic growth model analogous to internal DLA. We prove that the asymptotic shape of this model is a Euclidean ball, in a sense which is stronger than our earlier work. For the shape consisting of $n=\omega_d r^d$ sites, where $\omega_d$ is the volume of the unit ball in $\R^d$, we show that the inradius of the set of occupied sites is at least $r-O(\log r)$, while the outradius is at most $r+O(r^\alpha)$ for any $\alpha > 1-1/d$. For a related model, the divisible sandpile, we show that the domain of occupied sites is a Euclidean ball with error in the radius a constant independent of the total mass. For the classical abelian sandpile model in two dimensions, with $n=\pi r^2$ particles, we show that the inradius is at least $r/\sqrt{3}$, and the outradius is at most $(r+o(r))/\sqrt{2}$. This improves on bounds of Le Borgne and Rossin. Similar bounds apply in higher dimensions.Comment: [v3] Added Theorem 4.1, which generalizes Theorem 1.4 for the abelian sandpile. [v4] Added references and improved exposition in sections 2 and 4. [v5] Final version, to appear in Potential Analysi