35,701 research outputs found
QFT results for neutrino oscillations and New Physics
The CP asymmetry in neutrino oscillations, assuming new physics at production
and/or detection processes, is analyzed. We compute this CP asymmetry using the
standard quantum field theory within a general new physics scenario that may
generate new sources of CP and flavor violation. Well known results for the CP
asymmetry are reproduced in the case of V -A operators, and additional
contributions from new physics operators are derived. We apply this formalism
to SUSY extensions of the Standard Model where the contributions from new
operators could produce a CP asymmetry observable in the next generation of
neutrino experiments.Comment: 6 pages, 3 figures, version to be published in Phys.Rev.
Stacking-induced fluorescence increase reveals allosteric interactions through DNA
From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics. Here we take advantage of the environment-sensitive photoisomerization of cyanine dyes to probe local and global changes in DNA structure. We report that a covalently attached Cy3 dye undergoes strong enhancement of fluorescence intensity and lifetime when stacked in a nick, gap or overhang region in duplex DNA. This is used to probe hybridization dynamics of a DNA hairpin down to the single-molecule level. We also show that varying the position of a single abasic site up to 20 base pairs away modulates the dye–DNA interaction, indicative of through-backbone allosteric interactions. The phenomenon of stacking-induced fluorescence increase (SIFI) should find widespread use in the study of the structure, dynamics and reactivity of nucleic acids
Phenomenology Tools on Cloud Infrastructures using OpenStack
We present a new environment for computations in particle physics
phenomenology employing recent developments in cloud computing. On this
environment users can create and manage "virtual" machines on which the
phenomenology codes/tools can be deployed easily in an automated way. We
analyze the performance of this environment based on "virtual" machines versus
the utilization of "real" physical hardware. In this way we provide a
qualitative result for the influence of the host operating system on the
performance of a representative set of applications for phenomenology
calculations.Comment: 25 pages, 12 figures; information on memory usage included, as well
as minor modifications. Version to appear in EPJ
Dual Response Models for the Fractional Quantum Hall Effect
It is shown that the Jain mapping between states of integer and fractional
quantum Hall systems can be described dynamically as a perturbative
renormalization of an effective Chern-Simons field theory. The effects of
mirror duality symmetries of toroidally compactified string theory on this
system are studied and it is shown that, when the gauge group is compact, the
mirror map has the same effect as the Jain map. The extrinsic ingredients of
the Jain construction appear naturally as topologically non-trivial field
configurations of the compact gauge theory giving a dynamical origin for the
Jain hierarchy of fractional quantum Hall states.Comment: 8 pages LaTe
RGB-D Tracking and Optimal Perception of Deformable Objects
Addressing the perception problem of texture-less objects that undergo large deformations and movements, this article presents a novel RGB-D learning-free deformable object tracker in combination with a camera position optimisation system for optimal deformable object perception. The approach is based on the discretisation of the object''s visible area through the generation of a supervoxel graph that allows weighting new supervoxel candidates between object states over time. Once a deformation state of the object is determined, supervoxels of its associated graph serve as input for the camera position optimisation problem. Satisfactory results have been obtained in real time with a variety of objects that present different deformation characteristics
Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice
Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients. We hypothesize that specific Fcγ receptors for IgG constant region participate in atherogenesis by regulating the inflammatory state of lesional macrophages. In vivo we examined the role of activating Fcγ receptors in atherosclerosis progression using bone marrow transplantation from mice deficient in γ-chain (the common signaling subunit of activating Fcγ receptors) to hyperlipidemic mice. Hematopoietic deficiency of Fcγ receptors significantly reduced atherosclerotic lesion size, which was associated with decreased number of macrophages and T lymphocytes, and increased T regulatory cell function. Lesions of Fcγ receptor deficient mice exhibited increased plaque stability, as evidenced by higher collagen and smooth muscle cell content and decreased apoptosis. These effects were independent of changes in serum lipids and antibody response to oxidized low-density lipoproteins. Activating Fcγ receptor deficiency reduced pro-inflammatory gene expression, nuclear factor-κB activity, and M1 macrophages at the lesion site, while increasing anti-inflammatory genes and M2 macrophages. The decreased inflammation in the lesions was mirrored by a reduced number of classical inflammatory monocytes in blood. In vitro, lack of activating Fcγ receptors attenuated foam cell formation, oxidative stress and pro-inflammatory gene expression, and increased M2-associated genes in murine macrophages. Our study demonstrates that activating Fcγ receptors influence the macrophage phenotypic balance in the artery wall of atherosclerotic mice and suggests that modulation of Fcγ receptor-mediated inflammatory responses could effectively suppress atherosclerosis
Recommended from our members
Impact of disorder on dynamics and ordering in the honeycomb-lattice iridate Na2IrO3
Kitaev's honeycomb spin-liquid model and its proposed realization in materials such as α-RuCl3, Li2IrO3, and Na2IrO3 continue to present open questions about how the dynamics of a spin liquid are modified in the presence of non-Kitaev interactions as well as the presence of inhomogeneities. Here we use Na23 nuclear magnetic resonance to probe both static and dynamical magnetic properties in single-crystal Na2IrO3. We find that the NMR shift follows the bulk susceptibility above 30 K but deviates from it below; moreover below TN the spectra show a broad distribution of internal magnetic fields. Both of these results provide evidence for inequivalent magnetic sites at low temperature, suggesting inhomogeneities are important for the magnetism. The spin-lattice relaxation rate is isotropic and diverges at TN, suggesting that the Kitaev cubic axes may control the critical quantum spin fluctuations. In the ordered state, we observe gapless excitations, which may arise from site substitution, emergent defects from milder disorder, or possibly be associated with nearby quantum paramagnetic states distinct from the Kitaev spin liquid
Bose-Einstein condensation in an optical lattice: A perturbation approach
We derive closed analytical expressions for the order parameter
and for the chemical potential of a Bose-Einstein Condensate loaded into
a harmonically confined, one dimensional optical lattice, for sufficiently
weak, repulsive or attractive interaction, and not too strong laser
intensities. Our results are compared with exact numerical calculations in
order to map out the range of validity of the perturbative analytical approach.
We identify parameter values where the optical lattice compensates the
interaction-induced nonlinearity, such that the condensate ground state
coincides with a simple, single particle harmonic oscillator wave function
- …