Cardiovascular Risk Factors in a Suburban Community in Nigeria

The burden of hypertension, a silent killer, continues to increase in low- and middle-income countries. This study evaluated blood pressure (BP) in healthy adults to determine their risk of developing hypertension and to reduce associatedmorbidity of the disease. Overall, 182 subjects aged >16 years participated in the study. Systolic (SBP) and diastolic blood pressure (DBP) was measured after a resting period usingmercury sphygmomanometer. Randomblood glucose (RBG) concentration was also determined. Regression models were used to determine risk of high BP wit

COVID-19 Pandemic: Perception, Practices and Preparedness in Nigeria

Since Coronavirus disease 19 (COVID-19) pandemic was declared a public health emergency of international concern by the World Health Organization (WHO) on the 30th of January, 2020. Nigeria, with 343 cases and 10 deaths as at April 14, 2020 is classified as one of the countries at high risk of importation of the disease from China. The ability to limit and control local transmission after importation depends on the application and execution of strict measures of detection, prevention and control. The initial response of some percentage of the population was of doubt due to the ignorance of the far-reaching effect of the virus. More than 1,700 leaders of religious groups and communities in all 36 States and FCT were therefore sensitized to increase awareness level and consequences of COVID-19 among the populace. Major response activities were initiated before the first case was reported and were upgraded within weeks after the number of cases began to rise. Based on previous experience of perception, and awareness of other viral disease outbreaks, COVID-19 infection prevention and control interventions recommended by WHO are yet to be fully entrenched in the Nigerian public health system in order to reduce the general risk of contracting SARS-CoV-2 from infected individuals. There is therefore the need to execute strict measures of detection, prevention and control and drive compliance with the Nigeria Centre for Disease Control (NCDC) and WHO guidelines in Nigeria

POWER FACTOR CORRECTION USING STATIC CAPACITOR: A CASE STUDY OF NIGERIAN 330KV GRID SYSTEM

This paper work is concerned with the power factor correction using static capacitor being a case study of Nigerian 330kV Grid System. The research involves collection of various data relevant to the study from National Control Centre (NCC), Osogbo. The analysis is limited to the generator buses that have low power factors. Presented in this paper work is also the mathematical modeling of equations involving system monthly and annual savings. Simulations were done using MATLAB software package. The value of the static capacitor adopted and injected in each of the generator buses is 30kVar which is within the acceptable range of 25kVar to 40kVar. Where low power factors were noticed at the generator bus, static capacitor is injected to correct the low power factors especially at those buses. Typical examples are buses 2 (Jebba), 3 (Shiroro), 4 (Sapele), 5 (Delta) and 6 (Afam). The injection of static capacitor further leads to reduction in the load current in each of the generator buses and   consequently, an increase in the system annual savings

Enhanced Antioxidant Capacity Following Selenium Supplemented Antimalarial Therapy in Plasmodium berghei Infected Mice

The effect of the co-administration of artemether, lumefantrine and selenium was studied in mice infected with Plasmodium bergheiparasite. The mice were divided into seven groups of six animals per group.All groups except A were parasitized. Group A (unparasitized/untreated) and B (parasitized/untreated) served as the positive and negative control respectively, these were administered with olive oil. Animals in groups C and D were treated with 8 and 48 mg/kg/bw of artemether and lumefantrine respectively while group E was treated with a combination of artemether and lumefantrine (8: 48 mg/kg/bw). Animals in group F were treated with 0.945 mg/kg/bw of selenium only and group G was treated with a combination of artemether, lumefantrine and selenium (8:48:0.945 mg/kg/bw). All the treatment was done for a three day period. These animals were subsequently anaesthetized and the organs were excised. Homogenates were prepared for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein, reduced Glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) assays. The results showed a significant (p<0.05) difference in the levels of ALP and MDA in group B, while a significant difference was observed in the levels of ALP, total protein, CAT and MDA in group G when compared with the parasitized group. Histopathological analysis showed no presence of inflammatory cells in group G when compared with group B. It may be concluded that the combination of artemether, lumefantrine and selenium showed a more potent effect against the parasite than the group treated with artemether and lumefantrine, thus, helps to combat post-infection oxidative stress in susceptible cells

Epidemiology of Plasmodium falciparum infection and drug resistance markers in Ota Area, Southwestern Nigeria

Purpose: Effective routine monitoring and surveillance of parasite genes is a necessary strategy in the control of parasites’ resistance to antimalarial drugs, according to the WHO’s recommendation. This cross-sectional study therefore aimed at carrying out an epidemiological analysis on malaria incidence in Ado-Odo/Ota, Ogun State. Patients and methods: Blood and corresponding saliva samples were collected from 1,243 subjects of all ages and sex presenting with fever and a parasitemia level ≥2,000 between September 2016 and March 2018. Samples were collected from selected health facilities in the study area of Ogun state to establish the prevalence of falciparum malaria and determine resistance genes harbored by the parasites. The overall prevalence of falciparum malaria in the study site by microscopic examination was 45.86%. The highest incidence of 57.42% was recorded among male subjects. Point mutations of K76T and N86Y in the Pfcrt and pfmdr-1 genes, as well as non-synonymous mutations in Pfk13 genes, were screened for and sequenced for further analysis. Results: Pfcrt was detectable in 57.42% of blood and 51.02% of saliva samples, respectively. About 34.78% of the subjects that were confirmed microscopically harbored the Pfmdr-1 mutated gene while 26.67% of the saliva samples revealed Pfmdr-1. Epidemiological studies identified the presence of wild-type Pfk13 genes in 21.84% of blood and 44.44% of saliva samples correspondingly. For each of the genes evaluated, saliva portrayed great diagnostic performance when compared with blood. Conclusion: Findings from this study have established the prevalence of malaria and the resistance pattern of P. falciparum in the study area. The findings may help in formulating drug policies and suggest the use of saliva as a noninvasive point-of-care method of diagnosing malaria potentially deployable to rural endemic areas

Awareness of Cassava Peel Utilization Forms among Cassava Processors in Rural Communities of Southwest, Nigeria

Significant quantities of generated peels are been thrown on dumping sites in southwest, Nigeria thereby constituting a source of environmental pollution. This study assessed the awareness of cassava peel utilization forms among cassava processors in rural communities of southwest, Nigeria. Interview guide was used to elicit information from 200 cassava processors through a multistage sampling technique. Data were analyzed with both descriptive and inferential statistics. Result revealed that majority of the cassava processors were women (76.5%), married (75.0%), and members of cassava processing associations (89.5%) with 73.0% having at least primary education. The mean age and cassava processing experience were 53.01 and 22.76 years respectively. About 23.0% of the processed cassava tubers constituted peels. The study also revealed that 50% of the cassava processors discarded peels as waste, 26% sold generated peels while 24% fed the peels to their livestock. Also 93.5% of the cassava processors were not aware of any cassava peel utilization technology. Chi-square analysis revealed that significant association existed between existing practice on cassava peel utilization (χ2=17.341, p&lt;0.05) and cassava processors’ awareness of cassava peel utilization forms. The study concluded that substantial quantity of peel been generated is discarded as waste due to lack of awareness of cassava peel utilization technologies in the study areas. The study therefore recommended that improved technologies on the utilization of cassava peel should be popularized through result demonstration among cassava processors in southwest, Nigeria

Efficiency of Histidine Rich Protein II-Based Rapid Diagnostic Tests for Monitoring Malaria Transmission Intensities in an Endemic Area

In recent years there has been a global decrease in the prevalence of malaria due to scaling up of control measures, hence global control efforts now target elimination and eradication of the disease. However, a major problem associated with elimination is asymptomatic reservoir of infection especially in endemic areas. This study aims to determine the efficiency of histidine rich protein II (HRP-2) based rapid diagnostic tests (RDT) for monitoring transmission intensities in an endemic community in Nigeria during the pre-elimination stage. Plasmodium falciparum asymptomatic malaria infection in healthy individuals and symptomatic cases were detected using HRP-2. RDT negative tests were re-checked by microscopy and by primer specific PCR amplification of merozoite surface protein 2 (msp-2) for asexual parasites and Pfs25 gene for gametocytes in selected samples to detect low level parasitemia undetectable by microscopy. The mean age of the study population (n=280) was 6.12 years [95% CI 5.16 – 7.08, range 0.5 – 55], parasite prevalence was 44.6% and 36.3% by microscopy and RDT respectively (p =0.056). The parasite prevalence of 61.5% in children aged >2 – 10 years was significantly higher than 3.7% rate in adults >18years (p < 0.0001, χ2 = 60.45). RDT detected additional 29.6% asymptomatic cases but a lower specificity of 68.8% in symptomatic carriers. In 15 selected RDT positive samples, only 6 were positive by PCR and no gametocyte was detected. The results indicate that HRP-2 RDTs are a vital tool for understanding transmission dynamics and detecting immune-suppressed, recent and asymptomatic infections, thus crucial to tackle low level transmission and eliminating malaria in endemic areas

Epidemiology of Plasmodium falciparum infection and drug resistance markers in Ota Area, Southwestern Nigeria

Purpose: Effective routine monitoring and surveillance of parasite genes is a necessary strategy in the control of parasites’ resistance to antimalarial drugs, according to the WHO’s recommendation. This cross-sectional study therefore aimed at carrying out an epidemiological analysis on malaria incidence in Ado-Odo/Ota, Ogun State. Patients and methods: Blood and corresponding saliva samples were collected from 1,243 subjects of all ages and sex presenting with fever and a parasitemia level ≥2,000 between September 2016 and March 2018. Samples were collected from selected health facilities in the study area of Ogun state to establish the prevalence of falciparum malaria and determine resistance genes harbored by the parasites. The overall prevalence of falciparum malaria in the study site by microscopic examination was 45.86%. The highest incidence of 57.42% was recorded among male subjects. Point mutations of K76T and N86Y in the Pfcrt and pfmdr-1 genes, as well as non-synonymous mutations in Pfk13 genes, were screened for and sequenced for further analysis. Results: Pfcrt was detectable in 57.42% of blood and 51.02% of saliva samples, respectively. About 34.78% of the subjects that were confirmed microscopically harbored the Pfmdr-1 mutated gene while 26.67% of the saliva samples revealed Pfmdr-1. Epidemiological studies identified the presence of wild-type Pfk13 genes in 21.84% of blood and 44.44% of saliva samples correspondingly. For each of the genes evaluated, saliva portrayed great diagnostic performance when compared with blood. Conclusion: Findings from this study have established the prevalence of malaria and the resistance pattern of P. falciparum in the study area. The findings may help in formulating drug policies and suggest the use of saliva as a noninvasive point-of-care method of diagnosing malaria potentially deployable to rural endemic area

Appraisal of Nuclear Energy as an Alternative Option in South Africa’s Energy Scenario: A Multicriteria Analysis

South Africa is being confronted with an irregular power supply, leading to persistent load shedding due to aged and unreliable coal-fired power plants. Connected with coal as a generating source for electricity from fossil fuels are environmental concerns such as emissions of greenhouse gases and climate change impacts. Nuclear energy can allay the country’s dependence on coal as a source of energy. This article, therefore, reviews the feasibility of nuclear energy using a multicriteria analysis technique. A combination of Strengths, weaknesses, Opportunities, and Threats (SWOT) analysis and Analytical Hierarchy Process (AHP) was used to evaluate the external and internal factors that could either positively or negatively affect the country’s nuclear energy expansion drive. From the analysis, the country’s enabling laws and regulatory framework recorded the highest score of 39.2% under the strengths for the sector. In the case of the weaknesses, the high cost of construction and long construction framework recorded the highest weight, of 50.47%. Energy export and demand under the opportunities recorded a weight of 52.09%, ranking it as the highest opportunity for the sector. Seismic events were identified as the biggest threat for nuclear power expansion in the country, and the experts assigned a weight of 42.5% to this factor. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Acknowledgments: The authors acknowledge with thanks the Centre for Postgraduate Studies and the Postdoctoral Fellowship/Research Committee of the Cape Peninsula University of Technology, and the Directorate of Research and Innovations of the University of Venda