The effect of the co-administration of artemether, lumefantrine and selenium was studied in mice infected
with Plasmodium bergheiparasite. The mice were divided into seven groups of six animals per group.All groups
except A were parasitized. Group A (unparasitized/untreated) and B (parasitized/untreated) served as the positive
and negative control respectively, these were administered with olive oil. Animals in groups C and D were treated
with 8 and 48 mg/kg/bw of artemether and lumefantrine respectively while group E was treated with a combination
of artemether and lumefantrine (8: 48 mg/kg/bw). Animals in group F were treated with 0.945 mg/kg/bw of selenium
only and group G was treated with a combination of artemether, lumefantrine and selenium (8:48:0.945 mg/kg/bw).
All the treatment was done for a three day period. These animals were subsequently anaesthetized and the organs
were excised. Homogenates were prepared for aspartate aminotransferase (AST), alanine aminotransferase (ALT),
alkaline phosphatase (ALP), total protein, reduced Glutathione (GSH), superoxide dismutase (SOD), catalase (CAT)
and malondialdehyde (MDA) assays. The results showed a significant (p<0.05) difference in the levels of ALP and
MDA in group B, while a significant difference was observed in the levels of ALP, total protein, CAT and MDA in
group G when compared with the parasitized group. Histopathological analysis showed no presence of inflammatory
cells in group G when compared with group B. It may be concluded that the combination of artemether, lumefantrine
and selenium showed a more potent effect against the parasite than the group treated with artemether and
lumefantrine, thus, helps to combat post-infection oxidative stress in susceptible cells
