4,483 research outputs found
Evidence, Mechanisms and Improved Understanding of Controlled Salinity Waterflooding Part 1 : Sandstones
Acknowledgements TOTAL are thanked for partial supporting Jackson through the TOTAL Chairs programme at Imperial College London, for supporting Vinogradov through the TOTAL Laboratory for Reservoir Physics at Imperial College London, and for granting permission to publish this work.Peer reviewedPostprin
Neuropathie démyélinisante au cours d’un traitement par anti-TNF alpha et revue de la littérature
Introduction
Tumor necrosis factor- (TNF) blockers are efficient in the treatment of autoimmune disorders such as inflammatory bowel disease and rheumatoid arthritis, but can induce CNS adverse effects including retrobulbar optic neuritis or aggravation of multiple sclerosis.
Observation
We report a case of progressive demyelinating polyneuropathy after initiation of Adalimumab (Humira®). Corticosteroid and intravenous immunoglobulins were ineffective but the neuropathy improved within six months after adalimunab discontinuation.
Discussion
This case, and other reports recently published suggest that anti-TNF alpha drugs can induce demyelinating neuropathy.
Conclusion
Clinicians should be on the lookout for signs evocating neuropathy in patients given anti TNF alpha
A retrospective analysis of the effects of adopting individual transferable quotas in the Tasmanian red rock lobster,Jasus edwardsii, fishery
Individual transferable quotas (ITQ) were implemented in the Tasmanian red rock lobster fishery in 1998
and ten years later we assessed the impacts on the fishery. Particular attention was devoted to investigating the performances
of the fishery with regard to three features identified as major impacts in the literature: rationalization of the
fishing fleet, change in fishing strategy in order to maximise the fisher’s profit and concentration of fishing rights and
activity. On average, the fishery reacted as expected and reached its objective in terms of reconstruction of the biomass,
but the overall assessment in terms of resulting profitability is not very conclusive. There is no evidence of decrease of
the profitability over the period of the study but the fishery is more reactive to external factors on its export market in
China than to changes in its own structure.The first author is supported by a PhD scholarship
co-funded by IFREMER and the joint CSIRO-UTAS Quantitative
Marine Science program (QMS
RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity
A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. We assessed the functional effects of editing at this site by expressing homomeric RDL receptors in Xenopus oocytes. After replacement of arginine 122 with a glycine, both agonist and fipronil potencies were shifted to the right in either fipronil-sensitive receptors or mutated resistant receptors (A301G/T350M). These data provide the first insight on the influence of RNA editing on GABA receptor function
From point cloud to BIM: a survey of existing approaches
International audienceIn order to handle more efficiently projects of restoration, documentation and maintenance of historical buildings, it is essentialto rely on a 3D enriched model for the building. Today, the concept of Building Information Modelling (BIM) is widely adoptedfor the semantization of digital mockups and few research focused on the value of this concept in the field of cultural heritage.In addition historical buildings are already built, so it is necessary to develop a performing approach, based on a first step ofbuilding survey, to develop a semantically enriched digital model. For these reasons, this paper focuses on this chain startingwith a point cloud and leading to the well-structured final BIM; and proposes an analysis and a survey of existing approacheson the topics of: acquisition, segmentation and BIM creation. It also, presents a critical analysis on the application of this chainin the field of cultural heritag
Gene flow estimation with microsatellites in a Malagasy seed orchard of Eucalyptus grandis
International audienceEucalyptus grandis has a mixed-mating repro- ductive system. Malagasy Eucalyptus seed orchards were established 15 years ago with two aims both based on panmixia: open-pollinated seed production and genetic improvement. The panmixia hypothesis has never been confirmed in the seed orchard. From a seedling seed- orchard stand comprising 349 trees and using data obtained with six selected microsatellite markers, pater- nity analysis was performed for 724 offspring collected on 30 adult trees. Paternity assignment, based on exclu- sion procedures and likelihood-ratio method, was achieved with high accuracy; the exclusion probability value was 0.997. The outcrossing rate was very high (96.7%). More than 50% of potential male trees (199 out of 349) in the seed orchard contributed to pollination for 440 offspring of 30 progenies (8.6% of the basic population). The pollination rate from outside the seed orchard was high (39.2%), but might be due to the small size of this seed orchard. This study showed that "panmixia-like pollination" can be assume
Overview of the international fishing activities on the Cleaver Bank and Frisian Front : update with Dutch, British, Danish, German, Belgian, Swedish and French data for 2010-2015
In response to a request to Wageningen University & Research from the Dutch Ministry of Economic Affairs an update of the data and analysis on the value of the fishing activities of the Dutch, British, Danish, German, Belgian, Swedish and French fishing fleets on the proposed closed areas on the Cleaver Bank and Frisian Front was prepared. This report uses the method presented in Chapter 5 of ‘Effects of seabed protection on the Frisian Front and Central Oyster Grounds’ (Van Oostenbrugge et al. 2015) to update the reports already published by Wageningen Economic Research on fishing activity on the proposed closed areas on the Cleaver Bank and Frisian Front (Hamon et al. 2013; Oostenbrugge and Hamon 2014). The effort, value and landings by the Dutch, British, Danish, German, Belgian, Swedish and French fishing fleets are presented for a five year period (2010-2015) and show variations over the last years but generally show a decline in effort in both areas. Value of landings and gross value added show an upward trend for the Dutch fishery in the Cleaver Bank (with a low point in 2013) but a downward trend for the British, German and Belgian fleets and for the Frisian Front. Main target species of the Cleaver Bank are plaice, targeted by the beam trawl fleet, followed by mackerel, cod and whiting in the rest of the demersal fleet. On the Frisian Front, gillnets target mainly sole and cod. The total value of landings has remained relatively stable on the Cleaver Bank between €1.6m and €2m over years (with the exception of the low 2013 value at €0.7m) while it remained low for the Frisian Front around €17,000 per year on average for the fleets from the countries considered. Within fleets, the dependency of individuals on the areas to be closed can greatly vary although the value of landings in the proposed closures represent less than 1% of the total value of landings for the Dutch fleet. For the Dutch fisheries about 30 to 40 vessels fish a minor part (less than 10%) of their revenue from the proposed closed areas on the Cleaver Bank and only 1 or 2 vessels get more than 10% of their revenue from the proposed closures. Between 15 and 20 vessels would be impacted by a seasonal closure on the Frisian Front net fishery, of those vessels only one fished more than 10% of its revenue in the proposed closure for one year
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