171 research outputs found
Langzeitige Änderungen des Salzgehaltes in der Unterweser
Anhand hundertjähriger Meßreihen wurden langfristige Salzgehaltsänderungen in der Unterweser und ihre möglichen Ursachen untersucht. Dabei wurde angestrebt, die natürlichen und die anthropogenen Einflüsse auf den Salzgehalt zu trennen. Trotz des unvollständigen Datensatzes konnten der Einfluß des Einzugsgebietes und Salzgehaltsschwankungen des angrenzenden Meeresgebietes nahezu eliminiert werden. Wegen der langzeitigen Änderungen der Gezeiten in der Nordsee waren genaue Aussagen über die Auswirkung der in den letzten hundert Jahren in der Unterweser durchgeführten Baumaßnahmen auf den Salzgehalt nicht möglich. Unsere Ergebnisse geben Hinweise für moderne Meßnetze zur Bestimmung der Wasserqualität
No attenuation of gastric distress or benefit to performance with adaptation to octanoate-rich esterified oils in female cyclists
A computational study of the effect of windscreen shape and flow resistivity on turbulent wind noise reduction
This is the published version. Copyright 2011 Acoustical Society of AmericaIn this paper, numerical simulations are used to study the turbulentwind noise reduction effect of microphone windscreens with varying shapes and flow resistivities. Typical windscreen shapes consisting of circular, elliptical, and rectangular cylinders are investigated. A turbulent environment is generated by placing a solid circular cylinder upstream of the microphone. An immersed-boundary method with a fifth-order weighted essentially non-oscillatory scheme is implemented to enhance the simulation accuracy for high-Reynolds number flow around the solid cylinder as well as at the interface between the open air and the porous material comprising the windscreen. The Navier–Stokes equations for incompressible flow are solved in the open air. For the flow inside the porous material, a modified form of the Zwikker–Kosten equation is solved. The results show that, on average, the circular and horizontal ellipse windscreens have similar overall wind noise reduction performance, while the horizontal ellipse windscreen with medium flow resistivity provides the most effective wind noise reduction among all the considered cases. The vertical ellipse windscreen with high flow resistivity, in particular, increases the wind noise because of increased self-generation of turbulence
Effect of withdrawal of fusafungine from the market on prescribing of antibiotics and other alternative treatments in Germany:a pharmacovigilance impact study
Carbenic nitrile imines: Properties and reactivity
Structures and properties of nitrile imines were investigated computationally at B3LYP and CCSD(T) levels. Whereas NBO analysis at the B3LYP DFT level invariably predicts a propargylic electronic structure, CCSD(T) calculations permit a clear distinction between propargylic, allenic, and carbenic structures. Nitrile imines with strong IR absorptions above ca. 2150 cm-1 have propargylic structures with a CN triple bond (RCNNSiMe 3 and R2BCNNBR2), and those with IR absorptions below ca. 2150 cm-1 are allenic (HCNNH, PhCNNH, and HCNNPh). Nitrile imines lacking significant cumulenic IR absorptions at 1900-2200 cm -1 are carbenic (R-(C:)-N=N-R′). Electronegative but lone pair-donating groups NR2, OR, and F stabilize the carbenic form of nitrile imines in the same way they stabilize "normal" singlet carbenes, including N-heterocyclic carbenes. NBO analyses at the CCSD(T) level confirm the classification into propargylic, allenic, and carbenic reactivity types. Carbenic nitrile imines are predicted to form azoketenes 21 with CO, to form [2+2] and [2+4] cycloadducts and borane adducts, and to cyclize to 1H-diazirenes of the type 24 in mildly exothermic reactions with activation energies in the range 29-38 kcal/mol. Such reactions will be readily accessible photochemically and thermally, e.g., under the conditions of matrix photolysis and flash vacuum thermolysis
Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
The Financial Burden of Non-Communicable Chronic Diseases in Rural Nigeria: Wealth and Gender Heterogeneity in Health Care Utilization and Health Expenditures
Objectives
Better insights into health care utilization and out-of-pocket expenditures for non-communicable chronic diseases (NCCD) are needed to develop accessible health care and limit the increasing financial burden of NCCDs in Sub-Saharan Africa.
Methods
A household survey was conducted in rural Kwara State, Nigeria, among 5,761 individuals. Data were obtained using biomedical and socio-economic questionnaires. Health care utilization, NCCD-related health expenditures and distances to health care providers were compared by sex and by wealth quintile, and a Heckman regression model was used to estimate health expenditures taking selection bias in health care utilization into account.
Results
The prevalence of NCCDs in our sample was 6.2%. NCCD-affected individuals from the wealthiest quintile utilized formal health care nearly twice as often as those from the lowest quintile (87.8% vs 46.2%, p = 0.002). Women reported foregone formal care more often than men (43.5% vs. 27.0%, p = 0.058). Health expenditures relative to annual consumption of the poorest quintile exceeded those of the highest quintile 2.2-fold, and the poorest quintile exhibited a higher rate of catastrophic health spending (10.8% among NCCD-affected households) than the three upper quintiles (4.2% to 6.7%). Long travel distances to the nearest provider, highest for the poorest quintile, were a significant deterrent to seeking care. Using distance to the nearest facility as instrument to account for selection into health care utilization, we estimated out-of-pocket health care expenditures for NCCDs to be significantly higher in the lowest wealth quintile compared to the three upper quintiles.
Conclusions
Facing potentially high health care costs and poor accessibility of health care facilities, many individuals suffering from NCCDs—particularly women and the poor—forego formal care, thereby increasing the risk of more severe illness in the future. When seeking care, the poor spend less on treatment than the rich, suggestive of lower quality care, while their expenditures represent a higher share of their annual household consumption. This calls for targeted interventions that enhance health care accessibility and provide financial protection from the consequences of NCCDs, especially for vulnerable populations
The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met. In fetal stages, HGF-neutralization, or c-Met gene destruction, leads to hypoplasia of many organs, indicating that HGF signals are essential for organ development. Endogenous HGF is required for self-repair of injured livers, kidneys, lungs and so on. In addition, HGF exerts protective effects on epithelial and non-epithelial organs (including the heart and brain) via anti-apoptotic and anti-inflammatory signals. During organ diseases, plasma HGF levels significantly increased, while anti-HGF antibody infusion accelerated tissue destruction in rodents. Thus, endogenous HGF is required for minimization of diseases, while insufficient production of HGF leads to organ failure. This is the reason why HGF supplementation produces therapeutic outcomes under pathological conditions. Moreover, emerging studies delineated key roles of HGF during tumor metastasis, while HGF-antagonism leads to anti-tumor outcomes. Taken together, HGF-based molecules, including HGF-variants, HGF-fragments and c-Met-binders are available as regenerative or anti-tumor drugs. Molecular analysis of the HGF-c-Met system could provide bridges between basic biology and clinical medicine
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