Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach

__Abstract__ Systemic treatment with tumor necrosis factor (TNF) is associated with side-effects, limiting its clinical use in the treatment of malignancies. To investigate the feasibility of other routes of administration experimental and clinical studies were started to establish the toxicity and antitumor activity of TNF after intratumoral (i.t.) injection. In a rat model for colon adenocarcinoma, tumor fragments, implanted subcutaneously or under the hepatic capsule, were treated with TNF injected i.v. or i.t. A dosage of 40 μg/kg was lethal when given i.v., but not i.t. Injection of TNF (40 μg/kg) directly into the tumor resulted in inhibition of tumor growth in the subcutaneous as well as subhepatic tumor model. A phase I study was started in patient

Visual acuity and quality of life in dry eye disease: Proceedings of the OCEAN group meeting

This article was developed from a roundtable meeting held on 16 January 2015 by the OCEAN group in Paris, France

EXTREME PRICING GOES VIRAL: LESSONS FOR TEACHING PRICE CONTROLS

Price controls are a popular topic among students. However, the effects of implementing price controls are not as straightforward as students typically expect, especially the unintended consequences that students tend to overlook. This paper provides three teaching guides designed to teach price controls which can be easily implemented in an introductory-level economics course. We build on the work of Geerling et al. (2023c) by using short-form viral videos from popular platforms such as YouTube and TikTok, which match the streaming and content medium of choice for Gen Z. The use of celebrities and social media influencers make abstract teaching moments more relatable to students. As such, this paper offers a unique opportunity for creatively teaching economics to a new generation of students

Bazinganomics: Economics of The Big Bang Theory

url:http://www.bazinganomics.com The website is designed to provide instructors with clips, explanations, and lesson plans related to economics concepts from TV’s 2nd most watched broadcast show of the 2014-2015 season, CBS’s The Big Bang Theory. The site contains approximately 100 clips. As the show continues to air (currently signed through the 2016-2017 season) the authors plan to increase the number of clips and lesson plans

SWIFTONOMICS: USING TAYLOR SWIFT TO TEACH ECONOMICS

Taylor Swift is the most iconic music artist of her generation; her current Eras Tour is already the highest grossing of all time. Given her fame, fortune, and popularity among Millennials and Gen Z, which make up the vast majority of today’s college and high school students, Taylor Swift’s career offers a myriad of opportunities for teaching economics. The impact of her career has led to a new term entering the economics lexicon: Swiftonomics (the economics of Taylor Swift and Swift’s impact on the economy). This paper provides two lesson plans that make use of the Taylor Swift phenomenon to illustrate the concepts of supply and demand and exchange rates. For each lesson plan, we provide links to videos and news articles and a range of assessment activities involving Quizizz and a standalone handout which can be used in-class or assigned for homework. The size, diversity, and devotion of Taylor Swift’s fanbase (colloquially known as Swifties) presents economic educators with a unique opportunity to incorporate economic lessons within their current curriculum, from high school through to an introductory economics course at the college level

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents. In the last decade alone, the sensitivity of profiling technologies has undergone huge improvements in detection sensitivity, thus allowing quantification of minute samples, for example body fluids that were previously difficult to assay. As a consequence, there has been a huge increase in tear fluid investigation, predominantly in the field of ocular surface disease. As tears are a more accessible and less complex body fluid (than serum or plasma) and sampling is much less invasive, research is starting to focus on how disease processes affect the proteomic, lipidomic and metabolomic composition of the tear film. By determining compositional changes to tear profiles, crucial pathways in disease progression may be identified, allowing for more predictive and personalised therapy of the individual. This article will provide an overview of the various putative tear fluid biomarkers that have been identified to date, ranging from ocular surface disease and retinopathies to cancer and multiple sclerosis. Putative tear fluid biomarkers of ocular disorders, as well as the more recent field of systemic disease biomarkers, will be shown

Lesson Plans for Teaching Economics with The Big Bang Theory

Using examples in the classroom from current and past television shows and movies is becoming increasingly common. Being able to relate ideas back to a popular clip or episode allows the instructor to reach students in ways the traditional lecture cannot. Building on the work of Tierney, Mateer, Smith, Wooten, and Geerling (2016), this paper introduces five lesson plans tied to clips from The Big Bang Theory that can be used in high school (9-12) economics courses

Dietary patterns and risk of inflammatory bowel disease in Europe: Results from the EPIC study

Background: Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium and the subsequent development of Crohn’s disease (CD) and ulcerative colitis (UC). Methods: In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n=110) or UC (n=244) during followup were matched with four controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking. Results: Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI 0.32-1.19, p trend=0.19) and 0.63 (95% CI 0.28-1.42, p trend=0.23) for CD and 0.80 (95% CI 0.50-1.30, p trend=0.40) and 0.81 (95% CI 0.49-1.34, p trend=0.60) for UC. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI 0.49-1.47). Conclusions: Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect

Landscape change and biodiversity values of floodplains along the River Vistula, Poland.

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