Waveform-based speaker representations for speech synthesis

Speaker adaptation is a key aspect of building a range of speech processing systems, for example personalised speech synthesis. For deep-learning based approaches, the model parameters are hard to interpret, making speaker adaptation more challenging. One widely used method to address this problem is to extract a fixed length vector as speaker representation, and use this as an additional input to the task-specific model. This allows speaker-specific output to be generated, without modifying the model parameters. However, the speaker representation is often extracted in a task-independent fashion. This allows the same approach to be used for a range of tasks, but the extracted representation is unlikely to be optimal for the specific task of interest. Furthermore, the features from which the speaker representation is extracted are usually pre-defined, often a standard speech representation. This may limit the available information that can be used. In this paper, an integrated optimisation framework for building a task specific speaker representation, making use of all the available information, is proposed. Speech synthesis is used as the example task. The speaker representation is derived from raw waveform, incorporating text information via an attention mechanism. This paper evaluates and compares this framework with standard task-independent forms.EPSRC International Doctoral Scholarship, reference number 10348827; St. John’s College Internal Graduate Scholarship; the European Unions Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 655764; EPSRC grant EP/I031022/1 (Natural Speech Technology

Ground state correlations and structure of odd spherical nuclei

It is well known that the Pauli principle plays a substantial role at low energies because the phonon operators are not ideal boson operators. Calculating the exact commutators between the quasiparticle and phonon operators one can take into account the Pauli principle corrections. Besides the ground state correlations due to the quasiparticle interaction in the ground state influence the single particle fragmentation as well. In this paper, we generalize the basic QPM equations to account for both mentioned effects. As an illustration of our approach, calculations on the structure of the low-lying states in $^{131}$Ba have been performed.Comment: 12 pages, 1 figur

A Pulse Model in Log-domain for a Uniform Synthesizer

The quality of the vocoder plays a crucial role in the performance of parametric speech synthesis systems. In order to improve the vocoder quality, it is necessary to reconstruct as much of the perceived components of the speech signal as possible. In this paper, we first show that the noise component is currently not accurately modelled in the widely used STRAIGHT vocoder, thus, limiting the voice range that can be covered and also limiting the overall quality. In order to motivate a new, alternative, approach to this issue, we present a new synthesizer, which uses a uniform representation for voiced and unvoiced segments. This synthesizer has also the advantage of using a simple signal model compared to other approaches, thus offering a convenient and controlled alternative for future developments. Experiments analysing the synthesis quality of the noise component shows improved speech reconstruction using the suggested synthesizer compared to STRAIGHT. Additionally an experiment about analysis/resynthesis shows that the suggested synthesizer solves some of the issues of another uniform vocoder, Harmonic Model plus Phase Distortion (HMPD). In text-to-speech synthesis, it outperforms HMPD and exhibits a similar, or only slightly worse, quality to STRAIGHT’s quality, which is encouraging for a new vocoding approach.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 655764. The research for this paper was also partly supported by EPSRC grant EP/I031022/1 (Natural Speech Technology)

Clonal Complex 258, the Most Frequently Found Multilocus Sequence Type Complex in KPC-2-Producing Klebsiella pneumoniae Isolated in Brazilian Hospitals

Universidade Federal de São Paulo, Lab Alerta, Div Infect Dis, Dept Med, São Paulo, BrazilUniversidade Federal de São Paulo, Cent Lab, Hosp São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, Lab Alerta, Div Infect Dis, Dept Med, São Paulo, BrazilUniversidade Federal de São Paulo, Cent Lab, Hosp São Paulo, São Paulo, BrazilWeb of Scienc

Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD

Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD. Daily calcitriol therapy has been reported to improve linear growth in children with renal bone disease, and 1,25-dihydroxyvitamin D is a key regulator of chondrocyte proliferation and differentiation. Whereas large intermittent doses of calcitriol can lower serum parathyroid hormone (PTH) levels and reverse the skeletal changes of secondary hyperparathyroidism, the impact of intermittent calcitriol therapy on linear growth in children is not known. Thus, we studied 16 pre-pubertal patients with bone biopsy-proven secondary hyperparathyroidism who completed a 12-month prospective clinical trial of intermittent calcitriol therapy. Biochemical results and growth data obtained during intermittent calcitriol therapy were compared to values determined during the preceding 12 months of daily calcitriol therapy in each study subject; changes in bone histology were assessed after one year of intermittent calcitriol therapy. Z-scores for height did not change during 12 months of daily calcitriol therapy. Although the skeletal lesions of secondary hyperparathyroidism improved in most patients, Z-scores for height decreased from -1.8 ± 0.32 to -2.0 ± 0.33, P < 0.01, during intermittent calcitriol therapy. The largest reductions were seen in patients who developed adynamic bone lesions after 12 months of treatment. Delta Z-scores for height correlated with serum PTH, r = 0.71, P < 0.01, and alkaline phosphatase levels, r = 0.67, P < 0.01, during intermittent calcitriol therapy but not during daily calcitriol therapy. The data suggest that high dose intermittent calcitriol therapy adversely affects linear growth, particularly in patients with the adynamic lesion. The higher doses of calcitriol or the intermittent schedule of calcitriol administration may directly inhibit chondrocyte activity within growth plate cartilage of children with end-stage renal disease

Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates

We report the microbiological characterization of four New Delhi metallo-beta-lactamase-1 (bla(NDM-1))-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. bla(NDM-1) was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (bla(KPC-2)) or aminoglycoside-resistance methylase ( armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of bla(NDM-1) in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Med, Lab Especial Microbiol Clin, São Paulo, SP, BrazilDASA, Lab Diagnost Amer, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Dept Med, Lab Especial Microbiol Clin, São Paulo, SP, BrazilWeb of Scienc

Antimicrobial activity of a library of thioxanthones and their potential as efflux pump inhibitors

The overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the resistance-nodulation-division family) and the NorA, from the major facilitator superfamily. In bacteria, these structures can also favor virulence and adaptation mechanisms, such as quorum-sensing and the formation of biofilm. In this study, the design and synthesis of a library of thioxanthones as potential efflux pump inhib-itors are described. The thioxanthone derivatives were investigated for their antibacterial activity and inhibition of efflux pumps, biofilm formation, and quorum-sensing. The compounds were also studied for their potential to interact with P-glycoprotein (P-gp, ABCB1), an efflux pump present in mammalian cells, and for their cytotoxicity in both mouse fibroblasts and human Caco-2 cells. The results concerning the real-time ethidium bromide accumulation may suggest a potential bacterial efflux pump inhibition, which has not yet been reported for thioxanthones. Moreover, in vitro studies in human cells demonstrated a lack of cytotoxicity for concentrations up to 20 µM in Caco-2 cells, with some derivatives also showing potential for P-gp modulation.This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry-CIIMAR), and under the project PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds and structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF, and CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019

Population of isomers in decay of the giant dipole resonance

The value of an isomeric ratio (IR) in N=81 isotones ($^{137}$Ba, $^{139}$Ce, $^{141}$Nd and $^{143}$Sm) is studied by means of the ($\gamma, n)$ reaction. This quantity measures a probability to populate the isomeric state in respect to the ground state population. In ($\gamma, n)$ reactions, the giant dipole resonance (GDR) is excited and after its decay by a neutron emission, the nucleus has an excitation energy of a few MeV. The forthcoming $\gamma$ decay by direct or cascade transitions deexcites the nucleus into an isomeric or ground state. It has been observed experimentally that the IR for $^{137}$Ba and $^{139}$Ce equals about 0.13 while in two heavier isotones it is even less than half the size. To explain this effect, the structure of the excited states in the energy region up to 6.5 MeV has been calculated within the Quasiparticle Phonon Model. Many states are found connected to the ground and isomeric states by $E1$, $E2$ and $M1$ transitions. The single-particle component of the wave function is responsible for the large values of the transitions. The calculated value of the isomeric ratio is in very good agreement with the experimental data for all isotones. A slightly different value of maximum energy with which the nuclei rest after neutron decay of the GDR is responsible for the reported effect of the A-dependence of the IR.Comment: 16 pages, 4 Fig