Local and non-local measures of acceleration in cosmology

Current cosmological observations, when interpreted within the framework of a homogeneous and isotropic Friedmann-Lemaitre-Robertson-Walker (FLRW) model, strongly suggest that the Universe is entering a period of accelerating expansion. This is often taken to mean that the expansion of space itself is accelerating. In a general spacetime, however, this is not necessarily true. We attempt to clarify this point by considering a handful of local and non-local measures of acceleration in a variety of inhomogeneous cosmological models. Each of the chosen measures corresponds to a theoretical or observational procedure that has previously been used to study acceleration in cosmology, and all measures reduce to the same quantity in the limit of exact spatial homogeneity and isotropy. In statistically homogeneous and isotropic spacetimes, we find that the acceleration inferred from observations of the distance-redshift relation is closely related to the acceleration of the spatially averaged universe, but does not necessarily bear any resemblance to the average of the local acceleration of spacetime itself. For inhomogeneous spacetimes that do not display statistical homogeneity and isotropy, however, we find little correlation between acceleration inferred from observations and the acceleration of the averaged spacetime. This shows that observations made in an inhomogeneous universe can imply acceleration without the existence of dark energy.Comment: 19 pages, 10 figures. Several references added or amended, some minor clarifications made in the tex

On the Possibility of Anisotropic Curvature in Cosmology

In addition to shear and vorticity a homogeneous background may also exhibit anisotropic curvature. Here a class of spacetimes is shown to exist where the anisotropy is solely of the latter type, and the shear-free condition is supported by a canonical, massless 2-form field. Such spacetimes possess a preferred direction in the sky and at the same time a CMB which is isotropic at the background level. A distortion of the luminosity distances is derived and used to test the model against the CMB and supernovae (using the Union catalog), and it is concluded that the latter exhibit a higher-than-expected dependence on angular position. It is shown that future surveys could detect a possible preferred direction by observing ~ 20 / (\Omega_{k0}^2) supernovae over the whole sky.Comment: Extended SNe analysis and corrected some CMB results. Text also extended and references added. 8 pages, 5 figure

Cytomegalovirus-associated pulmonary exacerbation in patients with cystic fibrosis.

CMV is an unusual cause of pulmonary exacerbation in immunocompetent individuals with CF http://ow.ly/Rdds30hlnjV

Homoconjugation enhances the photophysical and electrochemical properties of a new 3D intramolecular charge transfer iptycene displaying deep blue emission

A new structural class of 3D molecule capable of intramolecular charge transfer (ICT) is introduced, based upon an electron poor ring-fused triptycene core. Its photophysical and electrochemical properties are evaluated in comparison with an analogous molecule, representative of a single fin of the iptycene. Homoconjugation through the delocalised LUMO of the iptycene facilitates a great increase in transition probability both to and from the ICT state, while the deep blue photoluminescence of the single fin is retained. The peripherally distributed HOMO of the iptycene also permits reversible access to a tricationic state in a single step and at an oxidation potential lower than that of the single fin. This first example demonstrates great potential for this 3D design concept in producing new optoelectronic molecular materials

An Improved Treatment of Optics in the Lindquist-Wheeler Models

We consider the optical properties of Lindquist-Wheeler (LW) models of the Universe. These models consist of lattices constructed from regularly arranged discrete masses. They are akin to the Wigner-Seitz construction of solid state physics, and result in a dynamical description of the large-scale Universe in which the global expansion is given by a Friedmann-like equation. We show that if these models are constructed in a particular way then the redshifts of distant objects, as well as the dynamics of the global space-time, can be made to be in good agreement with the homogeneous and isotropic Friedmann-Lemaitre-Robertson-Walker (FLRW) solutions of Einstein's equations, at the level of <3% out to z~2. Angular diameter and luminosity distances, on the other hand, differ from those found in the corresponding FLRW models, while being consistent with the 'empty beam' approximation, together with the shearing effects due to the nearest masses. This can be compared with the large deviations found from the corresponding FLRW values obtained in a previous study that considered LW models constructed in a different way. We therefore advocate the improved LW models we consider here as useful constructions that appear to faithfully reproduce both the dynamical and observational properties of space-times containing discrete masses.Comment: 7 pages, 5 figure

Altered collective mitochondrial dynamics in the Arabidopsis \u3ci\u3emsh1\u3c/i\u3e mutant compromising organelle DNA maintenance

Mitochondria form highly dynamic populations in the cells of plants (and almost all eukaryotes). The characteristics and benefits of this collective behaviour, and how it is influenced by nuclear features, remain to be fully elucidated. Here, we use a recently developed quantitative approach to reveal and analyse the physical and collective ‘social’ dynamics of mitochondria in an Arabidopsis msh1 mutant where the organelle DNA maintenance machinery is compromised. We use a newly created line combining the msh1 mutant with mitochondrially targeted green fluorescent protein (GFP), and characterize mitochondrial dynamics with a combination of single-cell time-lapse microscopy, computational tracking, and network analysis. The collective physical behaviour of msh1 mitochondria is altered from that of the wild type in several ways: mitochondria become less evenly spread, and networks of inter-mitochondrial encounters become more connected, with greater potential efficiency for inter-organelle exchange—reflecting a potential compensatory mechanism for the genetic challenge to the mitochondrial DNA population, supporting more inter-organelle exchange. We find that these changes are similar to those observed in friendly, where mitochondrial dynamics are altered by a physical perturbation, suggesting that this shift to higher connectivity may reflect a general response to mitochondrial challenges, where physical dynamics of mitochondria may be altered to control the genetic structure of the mtDNA population

Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study

Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes and measured levels of selected metabolites immediately after stimulation. LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. Furthermore, LI-rMS effects were frequency-specific with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites suggested that higher spontaneous activity may have led to an increase in GABA release. Although the absence of organised neural circuits and other cellular contributors (e.g., excitatory neurons and glia) in the B50 cell line limits the degree to which our results can be extrapolated to the human brain, the changes we describe provide novel insights into how LI-rMS modulates neural tissue

Distance-redshift from an optical metric that includes absorption

We show that it is possible to equate the intensity reduction of a light wave caused by weak absorption with a geometrical reduction in intensity caused by a "transverse" conformal transformation of the spacetime metric in which the wave travels. We are consequently able to modify Gordon's optical metric to account for electromagnetic properties of ponderable material whose properties include both refraction and absorption. Unlike refraction alone however, including absorption requires a modification of the optical metric that depends on the eikonal of the wave itself. We derive the distance-redshift relation from the modified optical metric for Friedman-Lema\^itre-Robertson-Walker spacetimes whose cosmic fluid has associated refraction and absorption coefficients. We then fit the current supernovae data and provide an alternate explanation (other than dark energy) of the apparent acceleration of the universe.Comment: 2 figure

Modification to the Luminosity Distance Redshift Relation in Modified Gravity Theories

We derive an expression for the luminosity distance as a function of redshift for a flat Robertson-Walker spacetime perturbed by arbitrary scalar perturbations possibly produced by a modified gravity theory with two different scalar perturbation potentials. Measurements of the luminosity distance as function of redshift provide a constraint on a combination of the scalar potentials and so they can complement weak lensing and other measurements in trying to distinguish among the various alternative theories of gravity.Comment: 15 pages, we discuss in more detail how the luminosity distance expression can be used to differentiate among various theories of gravit

Light-cone averaging in cosmology: formalism and applications

We present a general gauge invariant formalism for defining cosmological averages that are relevant for observations based on light-like signals. Such averages involve either null hypersurfaces corresponding to a family of past light-cones or compact surfaces given by their intersection with timelike hypersurfaces. Generalized Buchert-Ehlers commutation rules for derivatives of these light-cone averages are given. After introducing some adapted "geodesic light-cone" coordinates, we give explicit expressions for averaging the redshift to luminosity-distance relation and the so-called "redshift drift" in a generic inhomogeneous Universe.Comment: 20 pages, 2 figures. Comments and references added, typos corrected. Version accepted for publication in JCA