1,503 research outputs found
Stability impact on wake development in moderately complex terrain
This paper uses a year of SCADA data from Whitelee Wind Farm near Glasgow to investigate wind turbine wake development in moderately complex terrain. Atmospheric stability measurements in terms of Richardson number from a met mast at an adjoining site have been obtained and used to assess the impact of stability on wake development. Considerable filtering of these data has been undertaken to ensure that all turbines are working normally and are well aligned with the wind direction. A group of six wind turbines, more or less in a line, have been selected for analysis, and winds within a 2 degree direction sector about this line are used to ensure, as far as possible, that all the turbines investigated are fully immersed in the wake/s of the upstream turbine/s. Results show how the terrain effects combine with the wake effects, with both being of comparable importance for the site in question. Comparison has been made with results from two commercial CFD codes for neutral stability, and reasonable agreement is demonstrated. Richardson number has been plotted against wind shear and turbulence intensity at a met mast on the wind farm that for the selected wind direction is not in the wake of any turbines. Good correlations are found indicating that the Richardson numbers obtained are reliable. The filtered data used for wake analysis were split according to Richardson number into two groups representing slightly stable to neutral, and unstable conditions. Very little difference in wake development is apparent. A greater difference can be observed when the data are separated simply by turbulence intensity, suggesting that, although turbulence intensity is correlated with stability, of the two it is the parameter that most directly impacts on wake development through mixing of ambient and wake flows
SiPM and front-end electronics development for Cherenkov light detection
The Italian Institute of Nuclear Physics (INFN) is involved in the
development of a demonstrator for a SiPM-based camera for the Cherenkov
Telescope Array (CTA) experiment, with a pixel size of 66 mm. The
camera houses about two thousands electronics channels and is both light and
compact. In this framework, a R&D program for the development of SiPMs suitable
for Cherenkov light detection (so called NUV SiPMs) is ongoing. Different
photosensors have been produced at Fondazione Bruno Kessler (FBK), with
different micro-cell dimensions and fill factors, in different geometrical
arrangements. At the same time, INFN is developing front-end electronics based
on the waveform sampling technique optimized for the new NUV SiPM. Measurements
on 11 mm, 33 mm, and 66 mm NUV SiPMs
coupled to the front-end electronics are presentedComment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
Wind turbine lifetime extension decision-making based on structural health monitoring
In this work, structural health monitoring data is applied to underpin a long-term wind farm lifetime extension strategy. Based on the outcome of the technical analysis, the case for an extended lifetime of 15 years is argued. Having established the lifetime extension strategy, the single wind turbine investigated within a wind farm is subjected to a bespoke economic lifetime extension case study. In this case study, the local wind resource is taken into consideration, paired with central, optimistic, and pessimistic operational cost assumptions. Besides a deterministic approach, a stochastic analysis is carried out based on Monte Carlo simulations of selected scenarios. Findings reveal the economic potential to operate profitably in a subsidy-free environment with a P90 levelised cost of energy of ÂŁ25.02 if no component replacement is required within the nacelle and ÂŁ42.53 for a complete replacement of blades, generator, and gearbox
Benign hereditary chorea and deletions outside NKX2-1 : what's the role of MBIP?
Heterozygous point mutations or deletions of the NKX2-1 gene cause benign hereditary chorea (BHC) or a various combinations of primary hypothyroidism, respiratory distress and neurological disorders. Deletions proximal to, but not encompassing, NKX2-1 have been described in few subjects with brain-lung-thyroid syndrome. We report on a three-generation Italian family, with 6 subjects presenting BHC and harboring a genomic deletion adjacent to NKX2-1 and including the gene MBIP, recently proposed to be relevant for the pathogenesis of brain-lung-thyroid syndrome. We observed a clear reduction of NKX2-1 transcript levels in fibroblasts from our patients compared to controls; this finding suggests that MBIP deletion affects NKX2-1 expression, mimicking haploinsufficiency caused by classical NKX2-1 related mutations
The Low Energy Tagger for the KLOE-2 experiment
The KLOE experiment at the upgraded DAFNE e+e- collider in Frascati (KLOE-2)
is going to start a new data taking at the beginning of 2010 with its detector
upgraded with a tagging system for the identification of gamma-gamma
interactions. The tagging stations for low-energy e+e- will consist in two
calorimeters The calorimeter used to detect low-energy e+e- will be placed
between the beam-pipe outer support structure and the inner wall of the KLOE
drift chamber. This calorimeter will be made of LYSO crystals readout by
Silicon Photomultipliers, to achieve an energy resolution better than 8% at 200
MeV.Comment: 4 pages, 5 figures, in the proceedings of "Frontier detectors for
frontier physics", isola d'Elba, Italy, May 200
Development of a new generation of 3D pixel sensors for HL-LHC
This paper covers the main technological and design aspects relevant to the development of a new generation of thin 3D pixel sensors with small pixel size aimed at the High-Luminosity LHC upgrades. (C) 2015 Elsevier B.V. All rights reserved
HPLC-HRMS Global Metabolomics Approach for the Diagnosis of “Olive Quick Decline Syndrome” Markers in Olive Trees Leaves
Olive quick decline syndrome (OQDS) is a multifactorial disease affecting olive plants. The onset of this economically devastating disease has been associated with a Gram-negative plant pathogen called Xylella fastidiosa (Xf). Liquid chromatography separation coupled to high-resolution mass spectrometry detection is one the most widely applied technologies in metabolomics, as it provides a blend of rapid, sensitive, and selective qualitative and quantitative analyses with the ability to identify metabolites. The purpose of this work is the development of a global metabolomics mass spectrometry assay able to identify OQDS molecular markers that could discriminate between healthy (HP) and infected (OP) olive tree leaves. Results obtained via multivariate analysis through an HPLC-ESI HRMS platform (LTQ-Orbitrap from Thermo Scientific) show a clear separation between HP and OP samples. Among the differentially expressed metabolites, 18 different organic compounds highly expressed in the OP group were annotated; results obtained by this metabolomic approach could be used as a fast and reliable method for the biochemical characterization of OQDS and to develop targeted MS approaches for OQDS detection by foliage analysis
Development and tests of a new prototype detector for the XAFS beamline at Elettra Synchrotron in Trieste
The XAFS beamline at Elettra Synchrotron in Trieste combines X-ray absorption
spectroscopy and X-ray diffraction to provide chemically specific structural
information of materials. It operates in the energy range 2.4-27 keV by using a
silicon double reflection Bragg monochromator. The fluorescence measurement is
performed in place of the absorption spectroscopy when the sample transparency
is too low for transmission measurements or the element to study is too diluted
in the sample. We report on the development and on the preliminary tests of a
new prototype detector based on Silicon Drift Detectors technology and the
SIRIO ultra low noise front-end ASIC. The new system will be able to reduce
drastically the time needed to perform fluorescence measurements, while keeping
a short dead time and maintaining an adequate energy resolution to perform
spectroscopy. The custom-made silicon sensor and the electronics are designed
specifically for the beamline requirements.Comment: Proceeding of the 6YRM 12th-14th Oct 2015 - L'Aquila (Italy).
Accepted for publication on Journal of Physics: Conference Serie
PET/MR in recurrent glioblastoma patients treated with regorafenib: [18F]FET and DWI-ADC for response assessment and survival prediction
Objective: The use of regorafenib in recurrent glioblastoma patients has been recently approved by the Italian Medicines Agency (AIFA) and added to the National Comprehensive Cancer Network (NCCN) 2020 guidelines as a preferred regimen. Given its complex effects at the molecular level, the most appropriate imaging tools to assess early response to treatment is still a matter of debate. Diffusion-weighted imaging and O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography ([18F]FET PET) are promising methodologies providing additional information to the currently used RANO criteria. The aim of this study was to evaluate the variations in diffusion-weighted imaging/apparent diffusion coefficient (ADC) and [18F]FET PET-derived parameters in patients who underwent PET/MR at both baseline and after starting regorafenib. Methods: We retrospectively reviewed 16 consecutive GBM patients who underwent [18F]FET PET/MR before and after two cycles of regorafenib. Patients were sorted into stable (SD) or progressive disease (PD) categories in accordance with RANO criteria. We were also able to analyze four SD patients who underwent a third PET/MR after another four cycles of regorafenib. [18F]FET uptake greater than 1.6 times the mean background activity was used to define an area to be superimposed on an ADC map at baseline and after treatment. Several metrics were then derived and compared. Log-rank test was applied for overall survival analysis. Results: Percentage difference in FET volumes correlates with the corresponding percentage difference in ADC (R = 0.54). Patients with a twofold increase in FET after regorafenib showed a significantly higher increase in ADC pathological volume than the remaining subjects (p = 0.0023). Kaplan-Meier analysis, performed to compare the performance in overall survival prediction, revealed that the percentage variations of FET- and ADC-derived metrics performed at least as well as RANO criteria (p = 0.02, p = 0.024 and p = 0.04 respectively) and in some cases even better. TBR Max and TBR mean are not able to accurately predict overall survival. Conclusion In recurrent glioblastoma patients treated with regorafenib, [18F]FET and ADC metrics, are able to predict overall survival and being obtained from completely different measures as compared to RANO, could serve as semi-quantitative independent biomarkers of response to treatment. Advances in knowledge Simultaneous evaluation of [18F]FET and ADC metrics using PET/MR allows an early and reliable identification of response to treatment and predict overall survival
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