1,934 research outputs found
Critical mass and the dependency of research quality on group size
Academic research groups are treated as complex systems and their cooperative
behaviour is analysed from a mathematical and statistical viewpoint. Contrary
to the naive expectation that the quality of a research group is simply given
by the mean calibre of its individual scientists, we show that intra-group
interactions play a dominant role. Our model manifests phenomena akin to phase
transitions which are brought about by these interactions, and which facilitate
the quantification of the notion of critical mass for research groups. We
present these critical masses for many academic areas. A consequence of our
analysis is that overall research performance of a given discipline is improved
by supporting medium-sized groups over large ones, while small groups must
strive to achieve critical mass.Comment: 16 pages, 6 figures consisting of 16 panels. Presentation and
reference list improved for version
Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells
Neuronal communication and endocrine signaling are fundamental for integrating
the function of tissues and cells in the body. Hormones released by endocrine
cells are transported to the target cells through the circulation. By contrast, transmitter
release from neurons occurs at specialized intercellular junctions, the synapses.
Nevertheless, the mechanisms by which signal molecules are synthesized,
stored, and eventually secreted by neurons and endocrine cells are very similar.
Neurons and endocrine cells have in common two different types of secretory
organelles, indicating the presence of two distinct secretory pathways. The synaptic
vesicles of neurons contain excitatory or inhibitory neurotransmitters, whereas the
secretory granules (also referred to as dense core vesicles, because of their electron
dense content) are filled with neuropeptides and amines. In endocrine cells, peptide
hormones and amines predominate in secretory granules. The function and content
of vesicles, which share antigens with synaptic vesicles, are unknown for most
endocrine cells. However, in B cells of the pancreatic islet, these vesicles contain
GABA, which may be involved in intrainsular signaling.'
Exocytosis of both synaptic vesicles and secretory granules is controlled by
cytoplasmic calcium. However, the precise mechanisms of the subsequent steps,
such as docking of vesicles and fusion of their membranes with the plasma membrane,
are still incompletely understood. This contribution summarizes recent observations
that elucidate components in neurons and endocrine cells involved in
exocytosis. Emphasis is put on the intracellular aspects of the release of secretory
granules that recently have been analyzed in detail
Presynaptic potentials and facilitation of transmitter release in the squid giant synapse.
Statistics of first-passage times in disordered systems using backward master equations and their exact renormalization rules
We consider the non-equilibrium dynamics of disordered systems as defined by
a master equation involving transition rates between configurations (detailed
balance is not assumed). To compute the important dynamical time scales in
finite-size systems without simulating the actual time evolution which can be
extremely slow, we propose to focus on first-passage times that satisfy
'backward master equations'. Upon the iterative elimination of configurations,
we obtain the exact renormalization rules that can be followed numerically. To
test this approach, we study the statistics of some first-passage times for two
disordered models : (i) for the random walk in a two-dimensional self-affine
random potential of Hurst exponent , we focus on the first exit time from a
square of size if one starts at the square center. (ii) for the
dynamics of the ferromagnetic Sherrington-Kirkpatrick model of spins, we
consider the first passage time to zero-magnetization when starting from
a fully magnetized configuration. Besides the expected linear growth of the
averaged barrier , we find that the rescaled
distribution of the barrier decays as for large
with a tail exponent of order . This value can be simply
interpreted in terms of rare events if the sample-to-sample fluctuation
exponent for the barrier is .Comment: 8 pages, 4 figure
Drawing Boundaries
In âOn Drawing Lines on a Mapâ (1995), I suggested that the different ways we have of drawing lines on maps open up a new perspective on ontology, resting on a distinction between two sorts of boundaries: fiat and bona fide. âFiatâ means, roughly: human-demarcation-induced. âBona fideâ means, again roughly: a boundary constituted by some real physical discontinuity. I presented a general typology of boundaries based on this opposition and showed how it generates a corresponding typology of the different sorts of objects which boundaries determine or demarcate. In this paper, I describe how the theory of fiat boundaries has evolved since 1995, how it has been applied in areas such as property law and political geography, and how it is being used in contemporary work in formal and applied ontology, especially within the framework of Basic Formal Ontology
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