551 research outputs found

    Advanced quantitative magnetic resonance imaging to study the physiopathology of multiple sclerosis

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    Adsorption of Line Segments on a Square Lattice

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    We study the deposition of line segments on a two-dimensional square lattice. The estimates for the coverage at jamming obtained by Monte-Carlo simulations and by 7th7^{th}-order time-series expansion are successfully compared. The non-trivial limit of adsorption of infinitely long segments is studied, and the lattice coverage is consistently obtained using these two approaches.Comment: 19 pages in Latex+5 postscript files sent upon request ; PTB93_

    Irreversible Deposition of Line Segment Mixtures on a Square Lattice: Monte Carlo Study

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    We have studied kinetics of random sequential adsorption of mixtures on a square lattice using Monte Carlo method. Mixtures of linear short segments and long segments were deposited with the probability pp and 1p1-p, respectively. For fixed lengths of each segment in the mixture, the jamming limits decrease when pp increases. The jamming limits of mixtures always are greater than those of the pure short- or long-segment deposition. For fixed pp and fixed length of the short segments, the jamming limits have a maximum when the length of the long segment increases. We conjectured a kinetic equation for the jamming coverage based on the data fitting.Comment: 7 pages, latex, 5 postscript figure

    A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation.

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    INTRODUCTION: The existence of partial volume effects in brain MR images makes it challenging to understand physio-pathological alterations underlying signal changes due to pathology across groups of healthy subjects and patients. In this study, we implement a new approach to disentangle gray and white matter alterations in the thalamus and the basal ganglia. The proposed method was applied to a cohort of early multiple sclerosis (MS) patients and healthy subjects to evaluate tissue-specific alterations related to diffuse inflammatory or neurodegenerative processes. METHOD: Forty-three relapsing-remitting MS patients and nineteen healthy controls underwent 3T MRI including: (i) fluid-attenuated inversion recovery, double inversion recovery, magnetization-prepared gradient echo for lesion count, and (ii) T1 relaxometry. We applied a partial volume estimation algorithm to T1 relaxometry maps to gray and white matter local concentrations as well as T1 values characteristic of gray and white matter in the thalamus and the basal ganglia. Statistical tests were performed to compare groups in terms of both global T1 values, tissue characteristic T1 values, and tissue concentrations. RESULTS: Significant increases in global T1 values were observed in the thalamus (p = 0.038) and the putamen (p = 0.026) in RRMS patients compared to HC. In the Thalamus, the T1 increase was associated with a significant increase in gray matter characteristic T1 (p = 0.0016) with no significant effect in white matter. CONCLUSION: The presented methodology provides additional information to standard MR signal averaging approaches that holds promise to identify the presence and nature of diffuse pathology in neuro-inflammatory and neurodegenerative diseases

    Jamming coverage in competitive random sequential adsorption of binary mixture

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    We propose a generalized car parking problem where cars of two different sizes are sequentially parked on a line with a given probability qq. The free parameter qq interpolates between the classical car parking problem of only one car size and the competitive random sequential adsorption (CRSA) of a binary mixture. We give an exact solution to the CRSA rate equations and find that the final coverage, the jamming limit, of the line is always larger for a binary mixture than for the uni-sized case. The analytical results are in good agreement with our direct numerical simulations of the problem.Comment: 4 pages 2-column RevTeX, Four figures, (there was an error in the previous version. We replaced it (including figures) with corrected and improved version that lead to new results and conclusions

    Avant-propos.

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    Medland 2020, A voice in common for Mediterranean forests and their products

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    In this article, the association Forêt Méditerranéenne seeks to offer an outsider’s perspective on the Medland 2020 project. A difficult task indeed, but worth every effort because it reaches into the very heart of the association’s preoccupations over the last 35 years. All the experiments and experience presented in this issue took place as part of the European Union’s projects for cooperation, contributing to a shared framework for the management of Mediterranean regions and localities by fostering the use and protection of natural resources and making the most, both economically and socially, out of these territories... This article attempts to analyse how pooling the results and sharing acquired knowhow can boost the success of all those involved in Mediterranean forestry

    Medland 2020, une parole partagée sur les forêts méditerranéennes et leurs produits

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    En proposant, à travers cet article, un regard extérieur sur le projet Medland 2020, l’association Forêt Méditerranéenne s’est prêtée à un exercice difficile, mais ô combien stimulant, puisqu’il touche au cœur de ses réflexions depuis maintenant 35 ans. Chaque expérience présentée dans ce numéro et réalisée dans le cadre de projets de coopération de l’Union européenne, participe à un cadre commun de gestion des territoires méditerranéens en promouvant l’utilisation et la protection des ressources naturelles, la valorisation sociale et économique de ces territoires... Cet article tente d’analyser en quoi la mise en commun et la capitalisation de ces résultats peut apporter un plus aux acteurs de la foresterie méditerranéenne..

    The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients.

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    Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary specificity and differential sensitivity to pathological brain changes compatible with brain inflammation, degeneration, and repair. Moreover, advanced magnetic resonance imaging (MRI) metrics with overlapping elements amplify the true tissue-related information and limit measurement noise. In this work, we combined multiple advanced MRI parameters to assess focal and diffuse brain changes over 2 years in a group of early-stage relapsing-remitting MS patients. Thirty relapsing-remitting MS patients with less than 5 years disease duration and nine healthy subjects underwent 3T MRI at baseline and after 2 years including T1, T2, T2* relaxometry, and magnetization transfer imaging. To assess longitudinal changes in normal-appearing (NA) tissue and lesions, we used analyses of variance and Bonferroni correction for multiple comparisons. Multivariate linear regression was used to assess the correlation between clinical outcome and multiparametric MRI changes in lesions and NA tissue. In patients, we measured a significant longitudinal decrease of mean T2 relaxation times in NA white matter (p = 0.005) and a decrease of T1 relaxation times in the pallidum (p < 0.05), which are compatible with edema reabsorption and/or iron deposition. No longitudinal changes in qMRI metrics were observed in controls. In MS lesions, we measured a decrease in T1 relaxation time (p-value < 2.2e-16) and a significant increase in MTR (p-value < 1e-6), suggesting repair mechanisms, such as remyelination, increased axonal density, and/or a gliosis. Last, the evolution of advanced MRI metrics-and not changes in lesions or brain volume-were correlated to motor and cognitive tests scores evolution (Adj-R(2) > 0.4, p < 0.05). In summary, the combination of multiple advanced MRI provided evidence of changes compatible with focal and diffuse brain repair at early MS stages as suggested by histopathological studies
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