Fundamental frequency height as a resource for the management of overlap in talk-in-interaction.

Overlapping talk is common in talk-in-interaction. Much of the previous research on this topic agrees that speaker overlaps can be either turn competitive or noncompetitive. An investigation of the differences in prosodic design between these two classes of overlaps can offer insight into how speakers use and orient to prosody as a resource for turn competition. In this paper, we investigate the role of fundamental frequency (F0) as a resource for turn competition in overlapping speech. Our methodological approach combines detailed conversation analysis of overlap instances with acoustic measurements of F0 in the overlapping sequence and in its local context. The analyses are based on a collection of overlap instances drawn from the ICSI Meeting corpus. We found that overlappers mark an overlapping incoming as competitive by raising F0 above their norm for turn beginnings, and retaining this higher F0 until the point of overlap resolution. Overlappees may respond to these competitive incomings by returning competition, in which case they raise their F0 too. Our results thus provide instrumental support for earlier claims made on impressionistic evidence, namely that participants in talk-in-interaction systematically manipulate F0 height when competing for the turn

The management of secondary lower limb lymphoedema in cancer patients: A systematic review.

BACKGROUND: Lower limb lymphoedema is a recognised complication of cancer commonly encountered in palliative care, associated with reduced mobility and poor quality of life. AIM: To evaluate the available evidence for the treatment of secondary lower limb lymphoedema in patients with malignancies. DESIGN: A systematic review of the literature. DATA SOURCES: The MEDLINE, Embase, LILACS, Science Citation Index, Cochrane Databases and conference proceedings for published data from date of inception to July 2014 were searched. Relevant unpublished studies via relevant databases, Internet searches and hand-searches of the bibliographies of relevant papers were performed. RESULTS: From 1617 citations, 32 papers were selected for full-text assessment. Two randomised trials and five observational studies were identified. The two randomised controlled trials evaluated graded compression stockings and Coumarin capsules, respectively. The five observational studies evaluated lymphovenous microsurgical shunts, pneumatic compression devices, compression bandages alone, manual lymphatic drainage with compression and a herbal remedy combining Coumarin, Ginkgo and Melitoto (with or without manual lymphatic drainage), respectively. The extracted studies showed substantial heterogeneity. Hence, a meta-analysis was inappropriate and not performed. CONCLUSION: Few studies have evaluated the clinical effectiveness and potential side effects of treatments for lower limb lymphoedema. Moreover, symptoms and quality-of-life assessments were inconsistently reported. All included studies report lower limb volume reduction after treatment, which includes complex decongestion therapy, graded compression stockings and lymphovenous microsurgical shunts. Adequately powered randomised controlled trials of these interventions are recommended. Effort should be made to establish standardised outcomes, to minimise bias and to improve reporting quality in future trials of treatment for lower limb lymphoedema

Orbital surveys and state resource management

The resource management implications of satellite earth resource surveys for the state of Ohio are discussed. Discussions cover environmental problems, planning future developments, and short- and long-range benefits of such resource management

Temporal frequency of radio emissions for the April 25, 1984 flare

The National Geophysical Data Center archives data of the solar-terrestrial environment. The USAF Radio Solar Telescope Network (RSTN) data allow performance of time series analysis to determine temporal oscillations as low as three seconds. The X13/3B flare which erupted in region 4474 (S12E43) on the 24 to 25 of April 1984, was selected. The soft X-rays, 1 to 8 A, remained above X-levels for 50 minutes and the radio emissions measured at Learmonth Solar Observatory reached a maximum of 3.15 x 10 to the 5th power SFUs at 410 MHz at 0000UT. A power spectral analysis of the fixed frequency RSTN data from Learmonth shows possible quasi-periodic fluctuations in the range two to ten seconds. Repetition rates or quasi-periodicities, in the case of the power spectral analysis, generally showed the same trends as the average solar radio flux at 245 and 8800 MHz. The quasi-periodicities at 1415 MHz showed no such trends

Spin Correlations in the Two-Dimensional Spin-5/2 Heisenberg Antiferromagnet Rb2MnF4

We report a neutron scattering study of the instantaneous spin correlations in the two-dimensional spin S=5/2 square-lattice Heisenberg antiferromagnet Rb_2MnF_4. The measured correlation lengths are quantitatively described, with no adjustable parameters, by high-temperature series expansion results and by a theory based on the quantum self-consistent harmonic approximation. Conversely, we find that the data, which cover the range from about 1 to 50 lattice constants, are outside of the regime corresponding to renormalized classical behavior of the quantum non-linear sigma model. In addition, we observe a crossover from Heisenberg to Ising critical behavior near the Neel temperature; this crossover is well described by a mean-field model with no adjustable parameters.Comment: 8 pages, LaTeX, with 6 included EPS figures, submitted to EPJ

Flux-Confinement in Dilatonic Cosmic Strings

We study dilaton-electrodynamics in flat spacetime and exhibit a set of global cosmic string like solutions in which the magnetic flux is confined. These solutions continue to exist for a small enough dilaton mass but cease to do so above a critcal value depending on the magnetic flux. There also exist domain wall and Dirac monopole solutions. We discuss a mechanism whereby magnetic monopolesmight have been confined by dilaton cosmic strings during an epoch in the early universe during which the dilaton was massless.Comment: 8 pages, DAMTP R93/3

Intersubjetividad y domesticación en el devenir de una región global: la territorialización del salmón en la Patagonia chilena

Este artículo examina transformaciones en la Patagonia chilena, región líder en la producción de salmón para mercados globalizados. Utilizando una aproximación etnográfica, aborda las posibilidades de considerar las intersubjetividades en los procesos de conformación de regiones importantes para la producción global de alimentos, argumentando contra algunas perspectivas que enfatizan en la interobjetividad al explorar relaciones humanas y no-humanas. En un mundo complejo y globalizado, la teoría del ensamblaje permite comprender cómo las transformaciones regionales son estimuladas por formas de bio-poder que generan nuevas relaciones entre vida, agencia y naturaleza. Se rastrean experimentos, encuentros y afectos, descentrando así miradas convencionales sobre domesticación de especies, desarrollo regional y producción de alimentos y abriendo un debate sobre las potencialidades y límites de interpretaciones no lineales de la realidad

Engineering liver

Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies. An explosion of micro- and nanofabrication, biomaterials, microfluidic, and other technologies potentially affords unprecedented opportunity to create microphysiological models of the human liver, but engineering design principles for how to deploy these tools effectively toward specific applications, including how to define the essential constraints of any given application (available sources of cells, acceptable cost, and user-friendliness), are still emerging. Arguably less appreciated is the parallel growth in computational systems biology approaches toward these same problems—particularly in parsing complex disease processes from clinical material, building models of response networks, and in how to interpret the growing compendium of data on drug efficacy and toxicology in patient populations. Here, we provide insight into how the complementary paths of engineering liver—experimental and computational—are beginning to interplay toward greater illumination of human disease states and technologies for drug development.National Institutes of Health (U.S.) (UH2TR000496)National Institutes of Health (U.S.) (R01-EB 010246)National Institutes of Health (U.S.) (R01-ES015241)National Institutes of Health (U.S.) (P30-ES002109

An evolutionary perspective on the kinome of malaria parasites

Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL, CaMK and CK1 groups found in yeast, plants and mammals, testifying to the ancient ancestry of these families. However, several hundred millions years of independent evolution, and the specific pressures brought about by first a photosynthetic and then a parasitic lifestyle, led to the emergence of unique features in the plasmodial kinome. These include taxon-restricted kinase families, and unique peculiarities of individual enzymes even when they have homologues in other eukaryotes. Here, we merge essential aspects of all three malaria-related communications that were presented at the Evolution of Protein Phosphorylation meeting, and propose an integrated discussion of the specific features of the parasite's kinome and phosphoproteome