Kajian Penerapan Material pada Selubung Bangunan yang Mempengaruhi Kenyamanan Termal dan Visual

Central Library of UI is one of the most important facility to support an educational activities at University of Indonesia, Depok. With the most important fungtion of this building, thermal and visual comfort is necessary for supporting an activities in it. This research purposed to know how the buliding cover materials influenced thermal and visual comfort in buildings. The research object selected because Central Library of UI has built with applicated sustainable concept. Thermal comfort influenced by thermal comfort quality, kind of color materials building cover selection, and transparent material broad. Visual comfort influenced by lighting system, lamp used, and direction and scoop of light. Research methods used in this study is a qualitative research method, quantitative, and qualitative quantitaived. At the end of results of quantitative and qualitative analysis of weighted quantitatively. This study is expected to be a reference when desiging libraries that support thermal and visual comfort in buliding

Kajian Penerapan Material pada Selubung Bangunan yang Mempengaruhi Kenyamanan Termal dan Visual

Central Library of UI is one of the most important facility to support an educational activities at University of Indonesia, Depok. With the most important fungtion of this building, thermal and visual comfort is necessary for supporting an activities in it. This research purposed to know how the buliding cover materials influenced thermal and visual comfort in buildings. The research object selected because Central Library of UI has built with applicated sustainable concept. Thermal comfort influenced by thermal comfort quality, kind of color materials building cover selection, and transparent material broad. Visual comfort influenced by lighting system, lamp used, and direction and scoop of light. Research methods used in this study is a qualitative research method, quantitative, and qualitative quantitaived. At the end of results of quantitative and qualitative analysis of weighted quantitatively. This study is expected to be a reference when desiging libraries that support thermal and visual comfort in buliding

Rancang Bangun Alat Pemipil Jagung Menggunakan Pedal Sepeda Sebagai Penggerak

Tujuan penelitian ini ialah untuk menghemat waktu dan tenaga pemipilan jagung pada cara tradisional serta mengurangi potensi kerusakan biji pada penggunaan mesin diesel. Untuk mengatasi efisensi pada cara tradisional hal yang dikembangkan ialah penggunaan mekanisme transmisi rantai dan sprocket pada sepeda. Sedangkan untuk mengatasi potensi kerusakan biji pada mesin pemipil bertenaga diesel, hal yang ditekankan ialah pahat pemipil yang digunakan. Pahat pemipil dipasang zig-zag pada dua landasan berupa ring, tiap landasan terdapat tiga buah pahat, sehingga pahat berjumlah enam buah. Pengujian dilakukan sebanyak tiga kali, dengan bulir jagung sebagai variabel tetap dan operator sebagai variable bebas. Kapasitas produksi pada cara tradisional sebesar 14,6 kg/ jam, sedangkan pada pengujian alat ialah sebesar 21,1 Kg/jam. Jika pada mesin pemipil bertenaga diesel terdapat 0,98% potensi kerusakan biji, maka pada pengujian pertama (p1), pengujian kedua (p2) dan pengujian ketiga (p3) tidak ditemukan adanya kerusakan pada biji jagung

TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt

Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg2+-permeable channel/α-kinase, may be important. We examined the role of TRPM7 in aldosterone-dependent cardiovascular and renal injury by studying aldosterone-salt treated TRPM7-deficient (TRPM7+/Δkinase) mice. Plasma/tissue [Mg2+] and TRPM7 phosphorylation were reduced in vehicle-treated TRPM7+/Δkinase mice, effects recapitulated in aldosterone-salt-treated wild-type mice. Aldosterone-salt treatment exaggerated vascular dysfunction and amplified cardiovascular and renal fibrosis, with associated increased blood pressure in TRPM7+/Δkinase mice. Tissue expression of Mg2+-regulated phosphatases (PPM1A, PTEN) was downregulated and phosphorylation of Smad3, ERK1/2, and Stat1 was upregulated in aldosterone-salt TRPM7-deficient mice. Aldosterone-induced phosphorylation of pro-fibrotic signaling was increased in TRPM7+/Δkinase fibroblasts, effects ameliorated by Mg2+ supplementation. TRPM7 deficiency amplifies aldosterone-salt-induced cardiovascular remodeling and damage. We identify TRPM7 downregulation and associated hypomagnesemia as putative molecular mechanisms underlying deleterious cardiovascular and renal effects of hyperaldosteronism

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income&nbsp;countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was &lt;1.1 kg m–2 in the vast majority of&nbsp;countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity