Electron Correlations in the Quasi-Two-Dimensional Organic Conductor θ\theta-(BEDT-TTF)2_{2}I3_{3} investigated by 13^{13}C NMR

We report a $^{13}$C-NMR study on the ambient-pressure metallic phase of the layered organic conductor $\theta$-(BEDT-TTF)$_{2}$I$_{3}$ [BEDT-TTF: bisethylenedithio-tetrathiafulvalene], which is expected to connect the physics of correlated electrons and Dirac electrons under pressure. The orientation dependence of the NMR spectra shows that all BEDT-TTF molecules in the unit cell are to be seen equivalent from a microscopic point of view. This feature is consistent with the orthorhombic symmetry of the BEDT-TTF sublattice and also indicates that the monoclinic $I_{3}$ sublattice, which should make three molecules in the unit cell nonequivalent, is not practically influential on the electronic state in the conducting BEDT-TTF layers at ambient pressure. There is no signature of charge disproportionation in opposition to most of the $\theta$-type BEDT-TTF salts. The analyses of NMR Knight shift, $K$, and the nuclear spin-lattice relaxation rate, $1/T_{1}$, revealed that the degree of electron correlation, evaluated by the Korringa ratio [$\varpropto 1/(T_{1}TK^{2}$)], is in an intermediate regime. However, NMR relaxation rate $1/T_{1}$ is enhanced above $\sim$ 200K, which possibly indicates that the system enters into a quantum critical regime of charge-order fluctuations as suggested theoretically.Comment: 19pages, 6figure

ICG-loaded mesoporous nanohybrid (Nd-doped Hydroxyapatite/Fe3O4) for photonic/magnetic hyperthermia and photodynamic therapy

Background: Multimodality nanoplatforms play a crucial role in advancing medical interventions by integrating multiple functionalities into a single system. However, issues like intricate production processes and biocompatibility persist. Herein, a facile synthesis of a biomaterial-based mesoporous nanocarrier, HAp:Nd+SPIONs@mSiO2, loaded with the near-infrared (NIR) emitting dye indocyanine green (ICG) is reported. Methods: HAp:Nd nanoparticles were synthesized via combustion methods. Thereafter, commercial SPIONs and HAp:Nd were integrated within a mesoporous silica via a modified Stöber approach. HAp:Nd+SPIONs@mSiO2 nanoplatform was characterized for particle size, porosity, and luminescence using TEM, BET, and luminescence spectroscopy. The synthesized nanoplatform was further loaded with ICG dye and the loading efficiency was analyzed via UV-Vis spectroscopy. Photonic and magnetic thermal heating of the ICG-loaded nanoplatform was also analyzed along with the photo-stimulated ROS generation ability. Finally, cytotoxicity and therapeutic analysis was performed in vitro using triple-negative breast cancer cells (MDA-MB-231). Results: The nanohybrid with ~100 nm average size, comprised of Nd-doped hydroxyapatite (HAp), Fe3O4 superparamagnetic iron oxide nanoparticles (SPIONs), and mesoporous silica, exhibiting magneto-luminescent properties. The mesoporous structure was loaded with ICG as a model drug (4.3 μg/mg of nanoparticles) where a pH-dependent release was observed. The nanocarrier demonstrated dual functionality by generating heat through magnetic and photonic stimulation, as well as producing reactive oxygen species (ROS) upon excitation with 808 nm light. In vitro bioevaluation on aggressive triple-negative breast cancer cells (MDA-MB-231) showed the high biocompatibility of nanohybrid with and without ICG and exhibited significant toxicity after irradiation of NIR light. Noticeably, the nanohybrids also exhibit the ability to monitor temperature changes via Nd3+ associated NIR luminescence. Conclusions: The nanoplatform integrates clinically relevant components, highlighting its potential for translation from the laboratory to clinical applications. The developed nanohybrids, with combined NIR-mediated photothermal and photodynamic effects, magnetic photothermal capabilities, and NIR/MR imaging, offer promise in addressing cancer heterogeneity and improving conventional treatments with reduced side effects

Glutamate induces autophagy via the two-pore channels in neural cells

NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2. However, the activities of glutamate that are mediated by NAADP remain unclear. In this study, we evaluated the effect of glutamate on autophagy in astrocytes at physiological, non-toxic concentration. We found that glutamate induces autophagy at similar extent as NAADP. By contrast, the NAADP antagonist NED-19 or SiRNA-mediated inhibition of TPC1/2 decreases autophagy induced by glutamate, confirming a role for NAADP in this pathway. The involvement of TPC1/2 in glutamate-induced autophagy was also confirmed in SHSY5Y neuroblastoma cells. Finally, we show that glutamate leads to a NAADP-dependent activation of AMPK, which is required for autophagy induction, while mTOR activity is not affected by this treatment. Taken together, our results indicate that glutamate stimulates autophagy via NAADP/TPC/AMPK axis, providing new insights of how Ca2+ signalling glutamate-mediated can control the cell metabolism in the central nervous system

Sharp error terms for return time statistics under mixing conditions

We describe the statistics of repetition times of a string of symbols in a stochastic process. Denote by T(A) the time elapsed until the process spells the finite string A and by S(A) the number of consecutive repetitions of A. We prove that, if the length of the string grows unbondedly, (1) the distribution of T(A), when the process starts with A, is well aproximated by a certain mixture of the point measure at the origin and an exponential law, and (2) S(A) is approximately geometrically distributed. We provide sharp error terms for each of these approximations. The errors we obtain are point-wise and allow to get also approximations for all the moments of T(A) and S(A). To obtain (1) we assume that the process is phi-mixing while to obtain (2) we assume the convergence of certain contidional probabilities

Vortex matching effect in engineered thin films of NbN

We report robust vortex matching effects in antidot arrays fabricated on thin films of NbN. The near absence of hysteresis between field sweep directions indicates a negligible residual pinning in the host thin film. Owing to the very small coherence length of NbN thin films ($\xi < 5 nm$), the observations suggests the possibility of probing physics of vortices at true nanometer length scales in suitably fabricated structures.Comment: Submitted to Appl. Phys. Let

Site-site memory equation approach in study of density/pressure dependence of translational diffusion coefficient and rotational relaxation time of polar molecular solutions: acetonitrile in water, methanol in water, and methanol in acetonitrile

We present results of theoretical study and numerical calculation of the dynamics of molecular liquids based on combination of the memory equation formalism and the reference interaction site model - RISM. Memory equations for the site-site intermediate scattering functions are studied in the mode-coupling approximation for the first order memory kernels, while equilibrium properties such as site-site static structure factors are deduced from RISM. The results include the temperature-density(pressure) dependence of translational diffusion coefficients D and orientational relaxation times t for acetonitrile in water, methanol in water and methanol in acetonitrile, all in the limit of infinite dilution. Calculations are performed over the range of temperatures and densities employing the SPC/E model for water and optimized site-site potentials for acetonitrile and methanol. The theory is able to reproduce qualitatively all main features of temperature and density dependences of D and t observed in real and computer experiments. In particular, anomalous behavior, i.e. the increase in mobility with density, is observed for D and t of methanol in water, while acetonitrile in water and methanol in acetonitrile do not show deviations from the ordinary behavior. The variety exhibited by the different solute-solvent systems in the density dependence of the mobility is interpreted in terms of the two competing origins of friction, which interplay with each other as density increases: the collisional and dielectric frictions which, respectively, increase and decrease with increasing density.Comment: 13 pages, 8 eps-figures, 3 tables, RevTeX4-forma

Phenomenological interaction between current quarks

We construct a phenomenological model which describes the dynamical chiral symmetry breaking (DCSB) of QCD vacuum and reproduces meson spectra. Quark condensates, the pion decay constant, and meson spectra are well reproduced by phenomenological interaction which consists of a linear confining potential, a Coulombic potential, and the 't Hooft determinant interaction. In this model, the 't Hooft determinant interaction plays a important role not to only \eta,\eta' mass difference, but other meson masses through DCSB.Comment: 18 pages, LaTe

Oscillation effects on supernova neutrino rates and spectra and detection of the shock breakout in a liquid Argon TPC

A liquid Argon TPC (ICARUS-like) has the ability to detect clean neutrino bursts from type-II supernova collapses. In this paper, we consider for the first time the four possible detectable channels, namely, the elastic scattering on electrons from all neutrino species, $\nu_e$ charged current absorption on $Ar$ with production of excited $K$, $\bar\nu_e$ charged current absorption on $Ar$ with production of excited $Cl$ and neutral current interactions on $Ar$ from all neutrino flavors. We compute the total rates and energy spectra of supernova neutrino events including the effects of the three--flavor neutrino oscillation with matter effects in the propagation in the supernova. Results show a dramatic dependence on the oscillation parameters and in the energy spectrum, especially for charged-current events. The shock breakout phase has also been investigated using recent simulations of the core collapse supernova. We stress the importance of the neutral current signal to decouple supernova from neutrino oscillation physics.Comment: 40 pages, 19 figures, version v2 accepted for publication in JCAP. accepted in JCA

Statistical-mechanical theory of ultrasonic absorption in molecular liquids

We present results of theoretical description of ultrasonic phenomena in molecular liquids. In particular, we are interested in the development of microscopical, i.e., statistical-mechanical framework capable to explain the long living puzzle of the excess ultrasonic absorption in liquids. Typically, ultrasonic wave in a liquid can be generated by applying the periodically alternating external pressure with the angular frequency that corresponds to the ultrasound. If the perturbation introduced by such process is weak - its statistical-mechanical treatment can be done with the use of the linear response theory. We treat the liquid as a system of interacting sites, so that all the response/aftereffect functions as well as the energy dissipation and generalized (wave-vector and frequency dependent) ultrasonic absorption coefficient are obtained in terms of familiar site-site static and time correlation functions such as static structure factors or intermediate scattering functions. To express the site-site intermediate scattering functions we refer to the site-site memory equations in the mode-coupling approximation for the first-order memory kernels, while equilibrium properties such as site-site static structure factors, direct and total correlation functions are deduced from the integral equation theory of molecular liquids known as RISM or one of its generalizations. All the formalism is phrased in a general manner, hence the obtained results are expected to work for arbitrary type of molecular liquid including simple, ionic, polar, and non-polar liquids.Comment: 14 pages, 1 eps-figure, RevTeX4-forma

A Common Explanation for the Atmospheric, Solar-Neutrino and Double Beta Decay Anomalies

We make a number of small changes, including correcting an error in our heavy-neutrino decay rate. None of our analysis is changed, either in substance or detail.Comment: 25 pages, 6 Figures, McGill-93/1