The High Resolution X-ray Spectrum of SS 433 using the Chandra HETGS

We present observations of SS 433 using the Chandra High Energy Transmission Grating Spectrometer. Many emission lines of highly ionized elements are detected with the relativistic blue and red Doppler shifts. The lines are measurably broadened to 1700 km/s (FWHM) and the widths do not depend significantly on the characteristic emission temperature, suggesting that the emission occurs in a freely expanding region of constant collimation with opening angle of 1.23 +/- 0.06 deg. The blue shifts of lines from low temperature gas are the same as those of high temperature gas within our uncertainties, again indicating that the hottest gas we observe to emit emission lines is already at terminal velocity. Fits to the emission line fluxes give a range of temperatures in the jet from 5e6 to 1e8 K. We derive the emission measure as a function of temperature for a four component model that fits the line flux data. Using the density sensitive Si XIII triplet, the characteristic electron density is 1e14 cm^{-3}, where the gas temperature is about 1.3e7 K. Based on an adiabatic expansion model of the jet, the electron densities drop from ~2e15 to 4e13 cm^{-3} at distances of 2e10 to 2e11 cm from the apex of the jet cone. The jet mass outflow rate is 1.5e-7 Msun / yr. The kinetic power is 3.2e38 erg/s, which is x1000 larger than the unabsorbed 2-10 keV X-ray luminosity. The bremsstrahlung emission associated with the lines can account for the entire continuum; we see no direct evidence for an accretion disk. The image from zeroth order shows extended emission at a scale of ~2", aligned in the general direction of the radio jets.Comment: 28 pages, 12 figures (1, 4, 5, and 6 are color), to appear in the Astrophysical Journa

Minority and mode conversion heating in (3He)-H JET plasma

Radio frequency (RF) heating experiments have recently been conducted in JET (He-3)-H plasmas. This type of plasmas will be used in ITER's non-activated operation phase. Whereas a companion paper in this same PPCF issue will discuss the RF heating scenario's at half the nominal magnetic field, this paper documents the heating performance in (He-3)-H plasmas at full field, with fundamental cyclotron heating of He-3 as the only possible ion heating scheme in view of the foreseen ITER antenna frequency bandwidth. Dominant electron heating with global heating efficiencies between 30% and 70% depending on the He-3 concentration were observed and mode conversion (MC) heating proved to be as efficient as He-3 minority heating. The unwanted presence of both He-4 and D in the discharges gave rise to 2 MC layers rather than a single one. This together with the fact that the location of the high-field side fast wave (FW) cutoff is a sensitive function of the parallel wave number and that one of the locations of the wave confluences critically depends on the He-3 concentration made the interpretation of the results, although more complex, very interesting: three regimes could be distinguished as a function of X[He-3]: (i) a regime at low concentration (X[He-3] < 1.8%) at which ion cyclotron resonance frequency (ICRF) heating is efficient, (ii) a regime at intermediate concentrations (1.8 < X[He-3] < 5%) in which the RF performance is degrading and ultimately becoming very poor, and finally (iii) a good heating regime at He-3 concentrations beyond 6%. In this latter regime, the heating efficiency did not critically depend on the actual concentration while at lower concentrations (X[He-3] < 4%) a bigger excursion in heating efficiency is observed and the estimates differ somewhat from shot to shot, also depending on whether local or global signals are chosen for the analysis. The different dynamics at the various concentrations can be traced back to the presence of 2 MC layers and their associated FW cutoffs residing inside the plasma at low He-3 concentration. One of these layers is approaching and crossing the low-field side plasma edge when 1.8 < X[He-3] < 5%. Adopting a minimization procedure to correlate the MC positions with the plasma composition reveals that the different behaviors observed are due to contamination of the plasma. Wave modeling not only supports this interpretation but also shows that moderate concentrations of D-like species significantly alter the overall wave behavior in He-3-H plasmas. Whereas numerical modeling yields quantitative information on the heating efficiency, analytical work gives a good description of the dominant underlying wave interaction physics

Mutagenic Potency of Food-Derived Heterocyclic Amines

The understanding of mutagenic potency has been primarily approached using ''quantitative structure activity relationships'' (QSAR). Often this method allows the prediction of mutagenic potency of the compound based on its structure. But it does not give the underlying reason why the mutagenic activities differ. We have taken a set of heterocyclic amine structures and used molecular dynamic calculations to dock these molecules into the active site of a computational model of the cytochrome P-450 1A1 enzyme. The calculated binding strength using Boltzman distribution constants was then compared to the QSAR value (HF/6-31G* optimized structures) and the Ames/Salmonella mutagenic potency. Further understanding will only come from knowing the complete set of mutagenic determinants. These include the nitrenium ion half-life, DNA adduct half-life, efficiency of repair of the adduct, and ultimately fixation of the mutation through cellular processes. For two isomers, PhIP and 3-Me-PhIP, we showed that for the 100-fold difference in the mutagenic potency a 5-fold difference can be accounted for by differences in the P450 oxidation. The other factor of 20 is not clearly understood but is downstream from the oxidation step. The application of QSAR (chemical characteristics) to biological principles related to mutagenesis is explored in this report

What Does It Take? California County Funding Requests for Recovery-Oriented Full Service Partnerships Under the Mental Health Services Act

The need to move mental health systems toward more recovery-oriented treatment modes is well established. Progress has been made to define needed changes but evidence is lacking about the resources required to implement them. The Mental Health Services Act (MHSA) in California was designed to implement more recovery-oriented treatment modes. We use data from county funding requests and annual updates to examine how counties budgeted for recovery-oriented programs targeted to different age groups under MHSA. Findings indicate that initial per-client budgeting for Full Services Partnerships under MHSA was maintained in future cycles and counties budgeted less per client for children. With this analysis, we begin to benchmark resource allocation for programs that are intended to be recovery-oriented, which should be evaluated against appropriate outcome measures in the future to determine the degree of recovery-orientation

Salivary Glucose Oxidase from Caterpillars Mediates the Induction of Rapid and Delayed-Induced Defenses in the Tomato Plant

Caterpillars produce oral secretions that may serve as cues to elicit plant defenses, but in other cases these secretions have been shown to suppress plant defenses. Ongoing work in our laboratory has focused on the salivary secretions of the tomato fruitworm, Helicoverpa zea. In previous studies we have shown that saliva and its principal component glucose oxidase acts as an effector by suppressing defenses in tobacco. In this current study, we report that saliva elicits a burst of jasmonic acid (JA) and the induction of late responding defense genes such as proteinase inhibitor 2 (Pin2). Transcripts encoding early response genes associated with the JA pathway were not affected by saliva. We also observed a delayed response to saliva with increased densities of Type VI glandular trichomes in newly emerged leaves. Proteomic analysis of saliva revealed glucose oxidase (GOX) was the most abundant protein identified and we confirmed that it plays a primary role in the induction of defenses in tomato. These results suggest that the recognition of GOX in tomato may represent a case for effector-triggered immunity. Examination of saliva from other caterpillar species indicates that saliva from the noctuids Spodoptera exigua and Heliothis virescens also induced Pin2 transcripts

The detection of fraud activities on the stock market through forward analysis methodology of financial discussion boards

Financial discussion boards (FDBs) have been widely used for a variety of financial knowledge exchange activities through the posting of comments on the FDBs. Popular public FDBs are prone to be used as a medium to spread false financial information due to having a larger group of audiences. Although online forums, in general, are usually integrated with anti-spam tools such as Akismet, moderation of posted contents heavily relies on human moderators. Unfortunately, popular FDBs attract many comments per day which realistically prevents human moderators from continuously monitoring and moderating possibly fraudulent contents. Such manual moderation can be extremely time-consuming. Moreover, due to the absence of useful tools, no relevant authorities are actively monitoring and handling potential financial crimes on FDBs. This paper presents a novel forward analysis methodology implemented in an Information Extraction (IE) prototype system named FDBs Miner (FDBM). This methodology aims to detect potentially illegal comments on FDBs while integrating share prices in the detection process as this helps to categorise the potentially illegal comments into different risk levels for investigation priority. The IE prototype system will first extract the public comments and per minute share prices from FDBs for the selected listed companies on London Stock Exchange (LSE). In the forward analysis process, the comments are flagged using a predefined Pump and Dump financial crime related keyword template. By only flagging the comments against the keyword template yields an average of 9.82% potentially illegal comments. It is unrealistic and unaffordable for human moderators to read these comments on a daily basis in long run. Hence, by integrating the share prices’ hikes and falls to categorise the flagged comments based on risk levels, it saves time and allows relevant authorities to prioritise and investigate into the higher risk flagged comments as it can potentially indicate real Pump and Dump crimes on FDBs

Cancer and psychiatric diagnoses in the year preceding suicide

BACKGROUND: Patients with cancer are known to be at increased risk for suicide but little is known about the interaction between cancer and psychiatric diagnoses, another well-documented risk factor. METHODS: Electronic medical records from nine healthcare systems participating in the Mental Health Research Network were aggregated to form a retrospective case-control study, with ICD-9 codes used to identify diagnoses in the 1 year prior to death by suicide for cases (N = 3330) or matching index date for controls (N = 297,034). Conditional logistic regression was used to assess differences in cancer and psychiatric diagnoses between cases and controls, controlling for sex and age. RESULTS: Among patients without concurrent psychiatric diagnoses, cancer at disease sites with lower average 5-year survival rates were associated with significantly greater relative risk, while cancer disease sites with survival rates of \u3e70% conferred no increased risk. Patients with most psychiatric diagnoses were at higher risk, however, there was no additional risk conferred to these patients by a concurrent cancer diagnosis. CONCLUSION: We found no evidence of a synergistic effect between cancer and psychiatric diagnoses. However, cancer patients with a concurrent psychiatric illness remain at the highest relative risk for suicide, regardless of cancer disease site, due to strong independent associations between psychiatric diagnoses and suicide. For patients without a concurrent psychiatric illness, cancer disease sites associated with worse prognoses appeared to confer greater suicide risk