Spanish statistical parametric speech synthesis using a neural vocoder

During the 2000s decade, unit-selection based text-to-speech was the dominant commercial technology. Meanwhile, the TTS research community has made a big effort to push statistical-parametric speech synthesis to get similar quality and more flexibility on the synthetically generated voice. During last years, deep learning advances applied to speech synthesis have filled the gap, specially when neural vocoders substitute traditional signal-processing based vocoders. In this paper we propose to substitute the waveform generation vocoder of MUSA, our Spanish TTS, with SampleRNN, a neural vocoder which was recently proposed as a deep autoregressive raw waveform generation model. MUSA uses recurrent neural networks to predict vocoder parameters (MFCC and logF0) from linguistic features. Then, the Ahocoder vocoder is used to recover the speech waveform out of the predicted parameters. In the first system SampleRNN is extended to generate speech conditioned on the Ahocoder generated parameters (mfcc and logF0), where two configurations have been considered to train the system. First, the parameters derived from the signal using Ahocoder are used. Secondly, the system is trained with the parameters predicted by MUSA, where SampleRNN and MUSA are jointly optimized. The subjective evaluation shows that the second system outperforms both the original Ahocoder and SampleRNN as an independent neural vocoder.Peer ReviewedPostprint (published version

Nuevos aportes al conocimiento del Paleozoico inferior del área de Salar del Rincón, Puna occidental, Argentina

Se presentan aquí nuevos hallazgos de graptolitos, trilobites y palinomorfos, tanto marinos como terrestres, realizados en el área de Salar del Rincón. Este análisis multidisciplinario constituye un nuevo aporte para el conocimiento del Paleozoico inferior de la Puna occidental. En el área han sido definidas dos unidades del Paleozoico inferior, la más antigua corresponde al complejo volcano-sedimentario de la Formación Las Vicuñas, constituido por areniscas silíceas y volcaniclásticas, lutitas y coquinas intercaladas con rocas volcánicas silíceas depositadas en un ambiente marino somero. En esta unidad se reconoció la presencia de dos especies de importancia en la correlación regional e intercontinental del límite Cambro-Ordovícico. Abundantes especímenes del trilobite Jujuyaspis keideli Kobayashi han sido identificados en coquinas, mientras que, rabdosomas multirramosos de graptolitos fueron coleccionados en lutitas negras y asignados aquí a Rhabdinopora flabelliformis parabola (Bulman), indicadora de una edad Tremadociana temprana. Por su parte, formas biseriadas conservadas en areniscas de grano fino a medio se han localizado por primera vez en el miembro superior de la Formación Salar del Rincón. Las mismas estarían indicando una edad ordovícica tardía a silúrica. Esta edad también es sugerida por la asociación de quitinozoos de la parte superior de este miembro, principalmente caracterizada por especies de Cyathochitina y Spinachitina de afinidades nordgondwánicas y laurénticas. Asimismo, el microfitoplancton marino (acritarcos y algas prasinofíceas) y las criptoesporas de origen terrestre, provenientes de niveles próximos al tope de la unidad, respaldan esta edad. En particular los acritarcos evidencian, como en otras regiones del mundo, un recambio durante el Hirnantiano, con la aparición de taxones típicamente silúricos que posteriormente se diversifican durante este último período. Este análisis brinda nuevos elementos de juicio para ajustar la edad de las unidades aflorantes en el área, confirmando que éstas representan un lapso temporal que involucra los límites Cambro-Ordovícico y, posiblemente, Ordovícico-Silúrico.Simposio I: 2º Simposio de bioestratigrafía y eventos del Paleozoico inferiorTrabajo subsidiado mediante los proyectos ANPCyT-PICT 1272 y CONICET-PIP 112-200801-01994.Facultad de Ciencias Naturales y Muse

Female-female competition is influenced by forehead patch expression in pied flycatcher females

There is increasing evidence that sexual selection operates in females and not only in males. However, the function of female signals in intrasexual competition has been little studied in species with conventional sex roles. In the Iberian populations of the pied flycatcher (Ficedula hypoleuca), some females express a white forehead patch, a trait that in other European populations, only males exhibit and has become a classical example in studies of sexual selection. Here, we investigated whether the expression of this trait plays a role in female-female competition during early breeding stages. To test this hypothesis, we simulated territorial intrusions by challenging resident females with stuffed female decoys expressing or not a forehead patch. We found that resident females directed more attacks per trial and maintained closer distances to non-patched decoys than to patched ones. Also, patched females were more likely to attack the decoy than non-patched females. Interestingly, females were more aggressive against the decoys when their mate was absent. This may indicate that females relax territory vigilance in the presence of their mate or that males interfere in the interaction between competing females. The behavior of resident males was also observed, although it was not affected by decoy's patch expression. Our findings suggest that the forehead patch plays a role in female intrasexual competition. If the forehead patch signals fighting ability, as it does in males, we may interpret that non-patched females probably avoided repeating costly agonistic encounters with the most dominant rivals.Fil: Morales, J.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Gordo, O.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; EspañaFil: Lobato, E.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España. Cibio - Centro de Investigação Em Biodiversidade E Recursos Genéticos; PortugalFil: Ippi, Silvina Graciela. Universidad Nacional del Comahue. Centro Reg.universidad Bariloche. Departamento de Zoología. Cátedra de Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Martínez de la Puente, J.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; EspañaFil: Tomás, G.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Merino, S.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Moreno, J.. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; Españ

Propiedades, ventajas e inconvenientes de los materiales utilizados en supercondensadores

Este trabajo recoge una visión general de las propiedades, ventajas e inconvenientes de los principales materiales usados en los electrodos de los condensadores electroquímicos (también denominados supercondensadores). La elección de estos materiales tiene una enorme influencia en las características finales del dispositivo electroquí- mico. Entre los materiales de electrodo disponibles para su aplicación en supercondensadores se incluyen los materiales porosos basados en carbón, los óxidos de metales de transición y los polímeros conductores. Cada una de estas familias de materiales presenta unas ventajas e inconvenientes, por ello, en numerosas ocasiones no se emplea un único tipo de material para la elaboración de los electrodos, sino que la tendencia va dirigida hacia el uso de electrodos híbridos, es decir, aquellos constituidos por materiales de distinta naturaleza que combinan los aspectos beneficiosos y compensan las limitaciones de cada uno de los materiales por separad

Experiencia inicial con la prótesis de despliegue rápido en posición aórtica Edwards Intuity

ResumenObjetivoDisponemos de una nueva clase de prótesis aórticas de despliegue rápido para tratamiento quirúrgico de la estenosis aórtica. Permitirían disminuir los tiempos quirúrgicos y facilitarían la cirugía mínimamente invasiva. Presentamos nuestra experiencia inicial con la válvula Edwards Intuity en el contexto del estudio multicéntrico Foundation.Pacientes y métodosEntre septiembre de 2012 y febrero de 2014 se implantaron 25 prótesis aórticas Edwards Intuity en 26 pacientes (77±4,3años; 52% varones). Veinticuatro (96%) fueron reemplazo valvular aislado, y 9 pacientes (36%) tuvieron abordaje mínimamente invasivo. Los pacientes fueron estudiados al alta, a los 3meses y al año de la intervención.ResultadosHubo éxito en el implante en el 96,2% de los pacientes (25/26). No hubo mortalidad hospitalaria. Seguimiento medio de 11±5,4meses, supervivencia acumulada del 96%. Un paciente falleció a los 11meses por un ictus isquémico. El tiempo medio de pinzamiento aórtico fue de 38,2±10,1min y el tiempo medio de circulación extracorpórea, de 62,4±11,1min. A los 3meses, el área valvular efectiva media fue de 1,70±0,42cm2. El 91% de los pacientes (23/25) estaban en grado funcionali en el seguimiento.ConclusionesEl implante de la válvula Edwards Intuity para el tratamiento de la estenosis aórtica ha sido factible, seguro y eficaz. Los tiempos de isquemia miocárdica y de circulación extracorpórea parecen reducirse en comparación con la cirugía valvular aórtica habitual. El comportamiento hemodinámico inicial de la prótesis Edwards Intuity es excelente.AbstractObjectiveA new class of rapid deployment prostheses is now available for surgical treatment of aortic stenosis. These prostheses offer the possibility of reducing the duration of cardiopulmonary bypass and aortic clamping times, and facilitate the use of minimally invasive surgery. We present our initial experience with the Edwards Intuity valve in the context of a multicentre Foundation study.Patients and methodsBetween September 2012 and February 2014, 25 Edwards Intuity valves were implanted in 26 patients (77±4.3years; 52% male). Twenty-four (96%) were isolated aortic valve replacement; a minimally invasive approach was used on 9 patients (36%). Patients were studied at discharge, three months, and one year after surgery.ResultsImplantation success rate was 96.2% (25/26). There was no hospital mortality. Mean follow-up of 11±5.54months, cumulative survival of 96%. One patient died eleven months after surgery due to ischaemic stroke. The mean aortic clamping time was 38.2±10.1minutes, and the mean cardiopulmonary bypass (CPB) time was 62.4±11.1minutes. In the echocardiography at 3months, the mean effective valve area was 1.70±0.42cm2, and 91% of patients (23/25) were in functional classi NYHA at follow-up.ConclusionsThe implantation of the Edwards Intuity valve for surgical treatment of aortic stenosis has shown to be feasible, safe and effective. Times of myocardial ischaemia and extracorporeal circulation appear to be reduced compared with normal aortic valve surgery. The initial haemodynamic performance of the Edwards Intuity prosthesis is excellent

Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo

The protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nanoparticles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles functionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin. In this study, we assessed whether a low (subclinical) dose of cisplatin could be utilized as a model of nausea and emesis in the dog while decreasing the severity of adverse events to allow repeated administration. The emetic, nausea-like behavior and potential biomarker response to both the clinical dose (70 mg/m2) and low dose (15 mg/m2) of cisplatin was assessed. Plasma creatinine concentrations and granulocyte counts were used to assess adverse effects on the kidneys and bone marrow, respectively. Nausea-like behavior and emesis was induced by both doses of cisplatin, but the latency to onset was greater in the low-dose group. No significant change in plasma creatinine was detected for either dose groups. Granulocytes were significantly reduced compared with baseline (P = 0.000) following the clinical, but not the low-dose cisplatin group. Tolerability of repeated administration was assessed with 4 administrations of an 18 mg/m2 dose cisplatin. Plasma creatinine did not change significantly. Cumulative effects on the granulocytes occurred, they were significantly decreased (P = 0.03) from baseline at 3 weeks following cisplatin for the 4th administration only. Our results suggest that subclinical doses (15 and 18 mg/m2) of cisplatin induce nausea-like behavior and emesis but have reduced adverse effects compared with the clinical dose allowing for repeated administration in crossover studies

Structural and Electronic Properties of Small Neutral (MgO)n Clusters

Ab initio Perturbed Ion (PI) calculations are reported for neutral stoichiometric (MgO)n clusters (n<14). An extensive number of isomer structures was identified and studied. For the isomers of (MgO)n (n<8) clusters, a full geometrical relaxation was considered. Correlation corrections were included for all cluster sizes using the Coulomb-Hartree-Fock (CHF) model proposed by Clementi. The results obtained compare favorably to the experimental data and other previous theoretical studies. Inclusion of correlaiotn is crucial in order to achieve a good description of these systems. We find an important number of new isomers which allows us to interpret the experimental magic numbers without the assumption of structures based on (MgO)3 subunits. Finally, as an electronic property, the variations in the cluster ionization potential with the cluster size were studied and related to the structural isomer properties.Comment: 24 pages, LaTeX, 7 figures in GIF format. Accepted for publication in Phys. Rev.

Massive Spin-2 States as the Origin of the Top Quark Forward-Backward Asymmetry

We show that the anomalously large top quark forward-backward asymmetry observed by CDF and D\O\, can naturally be accommodated in models with flavor-violating couplings of a new massive spin-2 state to quarks. Regardless of its origin, the lowest-order couplings of a spin-2 boson to fermions are analogous to the coupling of the graviton to energy/momentum, leading to strong sensitivity of the effects associated with its virtual exchange to the energy scales at hand. Precisely due to this fact, the observed dependence of the asymmetry on the $t\bar t$ invariant mass fits nicely into the proposed framework. In particular, we find a vast parameter space which can lead to the central value for the observed forward-backward asymmetry in the high mass bin, while being in accord with all of the existing experimental constraints.Comment: added discussion of differential observables at the LHC, matches version accepted for publication in JHE