Adult BMI change and risk of Breast Cancer: National Health and Nutrition Examination Survey (NHANES) 2005-2010

OBJECTIVE: Breast cancer is the second leading cause of cancer mortality among women in the developed world. This study assessed the association between occurrence of breast cancer and body mass index (BMI) change from age 25 to age closest to breast cancer diagnosis while exploring the modifying effects of demographic variables. METHODS: The National Health and Nutrition Examination Survey data were used. Women included were ≥50 years, not pregnant and without a diagnosis of any cancer but breast. The total sample included 2895 women (172 with breast cancer and 2723 controls with no breast cancer diagnosis). Multivariate logistic regression was used to estimate the OR and 95 % CIs and interaction evaluated by including an interaction term in the model. RESULTS: Women whose BMI increased from normal or overweight to obese compared to those who remained at a normal BMI were found to have a 2 times higher odds (OR = 2.1; 95 % CI 1.11-3.79) of developing breast cancer. No significant association was observed for women who increased to overweight. However, a more pronounced association was observed in non-Hispanic black women (OR = 6.6; 95 % CI 1.68-25.86) and a significant association observed when they increased from normal to overweight (OR = 4.2; 95 % CI 1.02-17.75). CONCLUSIONS: Becoming obese after age 25 is associated with increased risk of breast cancer in women over 50 years old, with non-Hispanic black women being at greatest risk

Impact of Nutritional (C: N Ratio and Source) on Growth, Oxalate Accumulation, and Culture pH by Sclerotinia Sclerotiorum.

The phytopathogenic fungi Sclerotinia sclerotiorum, causative of Sclerotinia stem rot of soybean was studied to determine the impact of culture media representing disparate carbon to nitrogen sources and ratios on mycelial growth, oxalate accumulation, and culture pH. The three parameters exhibited significant variations with respect to the differing preference for the nutrient sources and ratios; most oxalate accumulated on high CN (75:1) nutrient media, the intermediate CN (35:1) nutrient media exhibited the best growth potential, while the highest oxalate–to-biomass ratio occurred on poor CN (3.6:1) nutrient media and pH raised in low (10:1) and poor (3.6:1) nutrient media. Further, we made an attempt to identify the potential regulators for oxalate metabolism by HPLC analysis of metabolites present in the culture filtrate, which revealed 6–17 peaks. Nine peaks were identified as acetate, citrate, succinate, malate, oxalate, oxaloacetate, succinate, glycolate, and indole-3-acetic acids (IAA). Acetate, oxalate and malate were present in all the culture filtrates but in varying amounts. The other metabolites were not detected in some of the culture filtrates. Taken together, these results indicate that; 1) oxalate production did not correlate with growth; 2) oxalate accumulation and regulation is dependent on nutritional conditions and; 3) the decrease in culture pH was independent of oxalate accumulation. Such studies may lead to identification of most commendable media for laboratory assay and the rational design of strategies to regulate/depress oxalate accumulation and reduce its availability in plant foods. Key words: biomass, metabolites, mycelial, nutrition, oxalate, Sclerotinia sclerotioru

Tomato Management Practices and Diseases Occurrence in Mwea West Sub County

Tomato is an important crop in Mwea West Sub County, Kirinyaga County, Kenya. A survey was carried out in the area to investigate tomato management practices, diseases and pests that hinder tomato production. The study endeavoured to establish farmers’ knowledge on fusarium wilt disease and root-knot nematodes and the methods used to control them. Data was collected from two hundred and eighteen randomly selected small holder producers who were equally distributed in the study area. Data collected included tomato management practices, diseases and pests that hinder production. Majority (85.3%) of the respondents were males while a few (14.7%) were female. The respondents (71.6%) indicated that tomato was the most important crop grown for income generation in the area. Most important varieties grown were cultivars, Safari, Kilele F1, Prosta F1 and Rio- Grande. Most important diseases affecting tomato crop were; early blight (Alternaria solani) and late blight (Phytophthora infestans), fungal wilts (Fusarium sp. Verticillium sp. Rhizoctonia sp.) and bacterial wilt (Ralstonia solanacearum). Plant parasitic nematodes and pests (thrips, aphids, spider mites) were also reported in the study area. There was a significant(P<0.05) association between the following variables; type of land owner and major use of land, type of land owner and cropping system, source of agricultural information and whether or not to apply pesticides into the soil. Farmers were quite knowledgeable about tomato farming as they had access to information from various sources; however there are still major gaps in knowledge especially on diseases and pests. Keywords: Tomato, diseases, pests, nematodes, managemen

Milk Yield of Dairy Cattle Fed Common \u3ci\u3eUrochloa\u3c/i\u3e Grass in Kenya

Urochloa grass mainly grown in South America, East Asia and Australia has its origin in East and Central Africa. Its success in South America for animal production triggered interest in Kenya where the main forage species Napier grass was threatened by head smut and stunt diseases. Therefore, a study was carried out at Mtwapa research station in the coastal lowlands of Kenya under controlled condition to compare the lactation performance of dairy cattle fed on Urochloa hybrid cv. Mulato II, U. decumbens cv. Basilisk, U. brizantha cvs. Piata, MG-4 and Xaraes with Napier grass. An on-farm participatory study was conducted in eastern midlands of Kenya where farmers compared their local feeds (varied mixtures of Napier grass, maize stover and natural pastures) with either Piata, Xaraes, MG-4 or Basilisk). Results from the on-station experiment showed no significant differences (P \u3c 0.05) in daily milk yield between dairy cows fed Piata (4.7 kg) and those fed on Napier grass (4.6 kg) while cows fed on either Mulato II or Xaraes produced less (P \u3c 0.05) milk; 4.4 and 3.6 kg respectively. In the farmers’ trial, milk yield increased by 15 - 40% when they fed their cows on Urochloa grasses. The studies concluded that Urochloa grasses had potential to replace or compliment Napier grass in dairy feeding in Kenya towards increased milk production

Effect of ruminal plastic bags on haematological and biochemical parameters of sheep and goats

A study was carried out with the objective of determining the haematological and blood biochemical parameters in sheep and goats with plastic bags in the rumen for a period of 42 days. This was to indicate the possible influence of plastic bags in the rumen on blood parameters. 16, one-year old castrate Dorper sheep with a mean body weight of 26.8 kg (± 0.3 kg) and 16 one-year old castrate small East African goats with a mean weight of 24.5 kg (± 0.3 kg) were used for the study. The 16 sheep and 16 goats were divided into 4 groups of 4 animals each (n = 4). Three groups of each species were implanted with 129 g, 258 g and 387 g of plastic bags, respectively, in the rumen through rumenotomy and the fourth group of each species was control on which rumenotomy was done but with no implanting of plastic bags. Blood samples were obtained by jugular venipuncture from all sheep and goats every 2 weeks for analysis. The only haematological parameter that had significant change was platelets, which significantly (p < 0.05) increased in both sheep and goats with plastic bags in the rumen. However, mean values of erythrocytes, packed cell volume, haemoglobin and mean corpuscular volume decreased but not significantly in the sheep and goats with plastic bags in the rumen. The sheep and goats with plastic bags in the rumen had hyponatraemmia, hypochloridaemia and decreased aspartate aminotransferase enzyme activity. The changes observed in haematological and biochemical parameters could be an indication of adverse effects on the production and well-being of sheep and goats that ingest these plastic bags. These finding may be of diagnostic importance in cases of rumen impaction with indigestible foreign bodies, particularly, plastic bags

Clinical manifestations in sheep with plastic bags in the rumen

Sixteen 1-year-old castrate Dorper sheep were used for the study. The animals were divided into four groups of four animals (n = 4). Three groups were implanted with 129 g, 258 g and 387 g of thin plastic bags into the rumen through rumenotomy, while the fourth group was subjected to rumenotomy without implanting plastic bags, and served as control. All the animals were monitored daily for 6 weeks following implantation. Presence of plastic bags in the rumen was characterized by anorexia, severe depression, discomfort, dehydration, firmness and asymmetrical distension of the abdomen, ruminal hypomotility and diarrhoea with intermittent constipation, weight loss, terminal recumbency and death. The severity of these clinical manifestations increased with increased quantities of plastic bags and their duration in the rumen. Sheep implanted with 258 g and 387 g lost 7.8 percent and 14.2 percent of their initial mean body weight, respectively, by the end of 6 weeks. Presence of plastic bags in the rumen could interfere with digestion, with a gradual loss in body weight, productivity and occasional mortality. Plastic bags in the rumen should be considered as a differential diagnosis in sheep presenting the observed clinical signs, especially in urban and periurban areas

Participatory Evaluation and Selection of Improved \u3ci\u3eUrochloa\u3c/i\u3e Grass Cultivars in Kenya

Low adoption of superior agricultural technologies has been attributed to insufficient attention given to farmers’ priorities and perceptions while developing technologies. There is therefore a need to involve farmers in development of new forage technologies in order to increase adoption. Participatory variety selection (PVS) was conducted on eight Urochloa grass cultivars in the coastal lowlands, eastern midlands, central highlands and northwestern highlands of Kenya to select cultivars that are more adaptable in each region. The eight Urochloa cultivars; U. brizantha cvs. Marandu, Xaraes, Piatã, MG4, U. decumbens cv. Basilisk, U. humidicola cvs. Llanero and Humidicola, and U. hybrid cv. Mulato II were evaluated against cultivated local grasses; Rhodes grass (Chloris gayana cv. KATR3) and Napier grass (Pennisetum purpureum cv. Kakamega 1). In each region, farmers were engaged in development of selection criteria through focus group discussions. For each criterion, farmers’ scored on individual grass cultivars using a Likert scale of 1 to 4 with higher scores indicating high cultivar preference. Farmers considered 12 to17 plant attributes in the selection of the most suitable forages for planting. The attributes included plant height, colour, spread, biomass among others. MG4 was the most preferred Urochloa cultivar in eastern midlands, central and northwestern highlands while Mulato II was most preferred in coastal lowlands. The study concluded that, the selected Urochloa cultivars met the farmers’ needs and were advanced for on-farm testing and evaluation for livestock benefits

Factors Associated with Choice of Infant Feeding Practices among HIV-1 Positive Post-natal Clinic Attendees in Tharaka Nithi County

Background: Feeding practices for HIV-exposed infants plays a key role in determining the risk of morbidity and mortality. Infected mothers’ choice of infant feeding is influenced by many factors within the community hence challenging their decisions. We sought to determine factors associated with choice of HIV exposed infant feeding practices in the region. Methods: Two hundred and forty nine HIV infected mothers were systematically recruited.  Data on infant HIV status was obtained from facility records. Respondents were interviewed using a semi-structured questionnaire. Focus group discussions and key informant interviews were carried out to support primary data. Analysis was done using SPSS version 16.0. Logistic regression was used to determine association of factors that influenced choice of infant feeding practice. Results: Of the 249 respondents, 98% chose exclusively breastfeeding during prenatal counseling but majority did not sustain beyond 2 months, while replacement feeding was least practiced (2%) postnatal. Major factors that influenced feeding practices were mother’s education (OR 2.637; CI: 1.088-6.388), non-health care workers advise (OR 3.053; CI: 1.706-5.463), not belonging to support groups (OR 2.804; CI: 1.620-4.854) rejection of health care workers support (OR 3.386; CI: 1.937-5.919). Conclusion: Although exclusive breastfeeding was the preferred feeding choice among the respondents immediately after birth, it was not sustained beyond the second month of the infant’s life. Increased contact of HIV positive women with health care workers and professionals through promotion of trust in community health workers, attendance of ANC and delivery in hospital should be promoted.  Education efforts should also target non health care persons who influence feeding practices to reduce stigma among HIV positive mothers. Keywords:  Infant feeding practices; Stigm

Accelerate Scaling up Forage Intensification Using Novel Digital Extension Approach in Kenya

Wide scale adoption of diverse forages improves livestock productivity and farmers welfare. However, limited access to information and knowledge on forage production results in slow adoption in Kenya. There is need to enhance information and knowledge exchange among farming communities for efficient and effective adoption and decision-making. An inter-institutional pilot project was initiated in 2017 to scale-up forages in Kenya using a novel extension approach - the village knowledge centre (VKC). A VKC is an information and communication technology (ICT) digital platform-based linking farmers through smart phones and social media as a conduit for faster and effective information and knowledge. This paper shares the experiences of VKC intervention to scale up Urochloa grass technology among smallholder farmers for livestock productivity. Through the VKC support there has been increased access of information and knowledge on Urochloa grass management, conservation and livestock feeding. Approximately 702 farmers out of which 28% were women visited the VKC to seek information on Urochloa grass from May 2018 to May 2020. It has trained 22 lead farmers on the establishment and management of Urochloa grass. The VKC has created two WhatsApp groups for networking among farmers with over 330 members. Between September 2018 and May 2020, the groups shared 2550 messages on Urochloa management, conservation, and livestock feeding with other farmers in their communities. Additionally, the VKC has improved availability of Urochloa grass seeds to farmers. Over 530 farmers received the seeds through the VKC, while 500 made request though mobile phone Short Message Services (SMS) and were supplied using courier services. It was evident that VKC intervention has not only improved the adoption rate, but also led to increased forage productivity and higher income for farmers. There is a need to continue using tools such as the VKC in the dissemination of information on Urochloa grass and explore suitable funding for sustainability of the centre after the end of the project