Axial Torsion-Dirac spin Effect in Rotating Frame with Relativistic Factor

In the framework of spacetime with torsion and without curvature, the Dirac particle spin precession in the rotational system is studied. We write out the equivalent tetrad of rotating frame, in the polar coordinate system, through considering the relativistic factor, and the resultant equivalent metric is a flat Minkowski one. The obtained rotation-spin coupling formula can be applied to the high speed rotating case, which is consistent with the expectation.Comment: 6 page

The generating function for a particular class of characters of SU(n)

We compute the generating function for the characters of the irreducible representations of SU(n) whose associated Young diagrams have only two rows with the same number of boxes. The result is a rational determinantal expression in which both the numerator and the denominator have a simple structure when expressed in terms of Schur polynomials.Comment: 7 pages, no figure

The Einstein static universe with torsion and the sign problem of the cosmological constant

In the field equations of Einstein-Cartan theory with cosmological constant a static spherically symmetric perfect fluid with spin density satisfying the Weyssenhoff restriction is considered. This serves as a rough model of space filled with (fermionic) dark matter. From this the Einstein static universe with constant torsion is constructed, generalising the Einstein Cosmos to Einstein-Cartan theory. The interplay between torsion and the cosmological constant is discussed. A possible way out of the cosmological constant's sign problem is suggested.Comment: 8 pages, LaTeX; minor layout changes, typos corrected, one new equation, new reference [5], completed reference [13], two references adde

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

Purpose: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed “cancer stem cells” (CSCs). Methods: Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. Additionally, the notion of a “cellular hierarchy” within UM was investigated. Finally, the phenomenon of phenotypic plasticity in response to environmental factors was explored. Results: We demonstrate that expression of ALDH, CD44, and CD133 does not select for a subpopulation of stem-like cells in either UM cell lines or UM STCs. Furthermore, there is an absence of a cellular hierarchy in cell lines and all cells in culture are able to drive tumor progression. Last, we show that established UM cell lines and UM STCs are plastic in nature and switch their phenotype in response to environmental stimuli. Conclusions: We hypothesize that this capacity to undergo phenotypic plasticity may be a consequence of neural crest lineage and renders the exploration of the CSC hypothesis extremely challenging in UM

Evidence of neutral transcriptome evolution in plants

The transcriptome of an organism is its set of gene transcripts (mRNAs) at a defined spatial and temporal locus. Because gene expression is affected markedly by environmental and developmental perturbations, it is widely assumed that transcriptome divergence among taxa represents adaptive phenotypic selection. This assumption has been challenged by neutral theories which propose that stochastic processes drive transcriptome evolution. To test for evidence of neutral transcriptome evolution in plants, we quantified 18 494 gene transcripts in nonsenescent leaves of 14 taxa of Brassicaceae using robust cross-species transcriptomics which includes a two-step physical and in silicobased normalization procedure based on DNA similarity among taxa. Transcriptome divergence correlates positively with evolutionary distance between taxa and with variation in gene expression among samples. Results are similar for pseudogenes and chloroplast genes evolving at different rates. Remarkably, variation in transcript abundance among root-cell samples correlates positively with transcriptome divergence among root tissues and among taxa. Because neutral processes affect transcriptome evolution in plants, many differences in gene expression among or within taxa may be nonfunctional, reflecting ancestral plasticity and founder effects. Appropriate null models are required when comparing transcriptomes in space and time

Assessing the Impact of Vertical Land Motion on Twentieth Century Global Mean Sea Level Estimates

Near-global and continuous measurements from satellite altimetry have provided accurate estimates of global mean sea level in the past two decades. Extending these estimates further into the past is a challenge using the historical tide gauge records. Not only is sampling nonuniform in both space and time, but tide gauges are also affected by vertical land motion (VLM) that creates a relative sea level change not representative of ocean variability. To allow for comparisons to the satellite altimetry estimated global mean sea level (GMSL), typically the tide gauges are corrected using glacial isostatic adjustment (GIA) models. This approach, however, does not correct other sources of VLM that remain in the tide gauge record. Here we compare Global Positioning System (GPS) VLM estimates at the tide gauge locations to VLM estimates from GIA models, and assess the influence of non-GIA-related VLM on GMSL estimates. We find that the tide gauges, on average, are experiencing positive VLM (i.e., uplift) after removing the known effect of GIA, resulting in an increase of 0.24 ± 0.08 mm yr−1 in GMSL trend estimates from 1900 to present when using GPS-based corrections. While this result is likely dependent on the subset of tide gauges used and the actual corrections used, it does suggest that non-GIA VLM plays a significant role in twentieth century estimates of GMSL. Given the relatively short GPS records used to obtain these VLM estimates, we also estimate the uncertainty in the GMSL trend that results from limited knowledge of non-GIA-related VLM

HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease

Experimental results for nulling the effective thermal expansion coefficient of fused silica fibres under a static stress

We have experimentally demonstrated that the effective thermal expansion coefficient of a fused silica fibre can be nulled by placing the fibre under a particular level of stress. Our technique involves heating the fibre and measuring how the fibre length changes with temperature as the stress on the fibre was systematically varied. This nulling of the effective thermal expansion coefficient should allow for the complete elimination of thermoelastic noise and is essential for allowing second generation gravitational wave detectors to reach their target sensitivity. To our knowledge this is the first time that the cancelation of the thermal expansion coefficient with stress has been experimentally observed