Assessing user behaviour and acceptance in real-world automated driving: the L3Pilot project approach

The L3Pilot project, funded by H2020, is conducting the first large-scale piloting of SAE Level 3 automated driving in Europe. The main aim of the project is to address a number of key questions in a step towards introducing automated vehicles on European roads. This paper discusses the approach taken by the L3Pilot project, to evaluate user behaviour in, and acceptance of, automated driving in real-world pilots. Although some technical challenges associated with the development and demonstration of such technologies are well-documented, current methodologies, such as those used to evaluate Field Operational Tests (FOTs), offer little guidance about assessing the impact of automated driving on users’ behaviour and acceptance. This paper outlines the methods used and developed for assessing user behaviour and acceptance within the project, summarises some of the methodological challenges involved in collecting data during an automated driving pilot, and discusses some approaches we have developed to solve these multifaceted challenges

EVALUATION OF REMEDIATION TECHNOLOGIES FOR PLUTONIUM CONTAMINATED SOIL

Soils contaminated with radionuclides are an environmental concern at most Department of Energy (DOE) sites. Clean up efforts at many of these sites are ongoing using conventional remediation techniques. These remediation techniques are often expensive and may not achieve desired soil volume reduction. Several studies using alternative remediation techniques have been performed on plutonium-contaminated soils from the Nevada Test Site. Results to date exhibit less than encouraging results, but these processes were often not fully optimized, and other approaches are possible. Clemson University and teaming partner Waste Policy Institute, through a cooperative agreement with the National Environmental Technologies Laboratory, are assisting the Nevada Test Site (NTS) in re-evaluating technologies that have the potential of reducing the volume of plutonium contaminated soil. This efforts includes (1) a through literature review and summary of (a) NTS soil characterization and (b) volume reduction treatment technologies applied to plutonium-contaminated NTS soils, (2) an interactive workshop for vendors, representatives from DOE sites and end-users, and (3) bench scale demonstration of applicable vendor technologies at the Clemson Environmental Technologies Laboratory

Do drivers change their manual car-following behaviour after automated car-following?

There is evidence that drivers’ behaviour adapts after using different advanced driving assistance systems. For instance, drivers’ headway during car-following reduces after using adaptive cruise control. However, little is known about whether, and how, drivers’ behaviour will change if they experience automated car-following, and how this is affected by engagement in non-driving-related tasks (NDRT). The aim of this driving simulator study, conducted as part of the H2020 L3Pilot project, was to address this topic. We also investigated the effect of the presence of a lead vehicle during the resumption of control, on subsequent manual driving behaviour. Thirty-two participants were divided into two experimental groups. During automated car-following, one group was engaged in an NDRT (SAE Level 3), while the other group was free to look around the road environment (SAE Level 2). Both groups were exposed to Long (1.5 s) and Short (.5 s) Time Headway (THW) conditions during automated car-following, and resumed control both with and without a lead vehicle. All post-automation manual drives were compared to a Baseline Manual Drive, which was recorded at the start of the experiment. Drivers in both groups significantly reduced their time headway in all post-automation drives, compared to a Baseline Manual Drive. There was a greater reduction in THW after drivers resumed control in the presence of a lead vehicle, and also after they had experienced a shorter THW during automated car-following. However, whether drivers were in L2 or L3 did not appear to influence the change in mean THW. Subjective feedback suggests that drivers appeared not to be aware of the changes to their driving behaviour, but preferred longer THWs in automation. Our results suggest that automated driving systems should adopt longer THWs in car-following situations, since drivers’ behavioural adaptation may lead to adoption of unsafe headways after resumption of control

Managing Big Data for Addressing Research Questions in a Collaborative Project on Automated Driving Impact Assessment

While extracting meaningful information from big data is getting relevance, literature lacks information on how to handle sensitive data by different project partners in order to collectively answer research questions (RQs), especially on impact assessment of new automated driving technologies. This paper presents the application of an established reference piloting methodology and the consequent development of a coherent, robust workflow. Key challenges include ensuring methodological soundness and data validity while protecting partners’ intellectual property. The authors draw on their experiences in a 34-partner project aimed at assessing the impact of advanced automated driving functions, across 10 European countries. In the first step of the workflow, we captured the quantitative requirements of each RQ in terms of the relevant data needed from the tests. Most of the data come from vehicular sensors, but subjective data from questionnaires are processed as well. Next, we set up a data management process involving several partners (vehicle manufacturers, research institutions, suppliers and developers), with different perspectives and requirements. Finally, we deployed the system so that it is fully integrated within the project big data toolchain and usable by all the partners. Based on our experience, we highlight the importance of the reference methodology to theoretically inform and coherently manage all the steps of the project and the need for effective and efficient tools, in order to support the everyday work of all the involved research teams, from vehicle manufacturers to data analysts

Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis

Purpose: To evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired corneal innervation. Design: Phase II multicenter, randomized, double-masked, vehicle-controlled trial. Participants: Patients with stage 2 (moderate) or stage 3 (severe) NK in 1 eye. Methods: The REPARO phase II study assessed safety and efficacy in 156 patients randomized 1:1:1 to rhNGF 10 \u3bcg/ml, 20 \u3bcg/ml, or vehicle. Treatment was administered 6 drops per day for 8 weeks. Patients then entered a 48- or 56-week follow-up period. Safety was assessed in all patients who received study treatment, whereas efficacy was by intention to treat. Main Outcome Measures: Corneal healing (defined as <0.5-mm maximum diameter of fluorescein staining in the lesion area) was assessed by masked central readers at week 4 (primary efficacy end point) and week 8 (key secondary end point) of controlled treatment. Corneal healing was reassessed post hoc by masked central readers using a more conservative measure (0-mm staining in the lesion area and no other persistent staining). Results: At week 4 (primary end point), 19.6% of vehicle-treated patients achieved corneal healing (<0.5-mm lesion staining) versus 54.9% receiving rhNGF 10 \u3bcg/ml (+35.3%; 97.06% confidence interval [CI], 15.88\u201354.71; P < 0.001) and 58.0% receiving rhNGF 20 \u3bcg/ml (+38.4%; 97.06% CI, 18.96\u201357.83; P < 0.001). At week 8 (key secondary end point), 43.1% of vehicle-treated patients achieved less than 0.5-mm lesion staining versus 74.5% receiving rhNGF 10 \u3bcg/ml (+31.4%; 97.06% CI, 11.25\u201351.49; P = 0.001) and 74.0% receiving rhNGF 20 \u3bcg/ml (+30.9%; 97.06% CI, 10.60\u201351.13; P = 0.002). Post hoc analysis of corneal healing by the more conservative measure (0-mm lesion staining and no other persistent staining) maintained statistically significant differences between rhNGF and vehicle at weeks 4 and 8. More than 96% of patients who healed after controlled rhNGF treatment remained recurrence free during follow-up. Treatment with rhNGF was well tolerated; adverse effects were mostly local, mild, and transient. Conclusions: Topical rhNGF is safe and more effective than vehicle in promoting healing of moderate-to-severe NK

Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion

Background: During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione depletion and metabolic stress. Maintaining redox homeostasis is important for controlling proliferation and apoptosis in response to specific stimuli for a variety of cells. For T cells, the ability to generate specific response to antigen is dependent on the oxidation state of cell surface and cytoplasmic protein-thiols. Intracellular thiols are maintained in their reduced state by a network of redox regulating peptides, proteins and enzymes such as glutathione, thioredoxins and thioredoxin reductase. Here we have investigated whether any relationship exists between age and secreted or cell surface thioredoxin-1, intracellular glutathione concentration and T cell surface thioredoxin 1 (Trx-1) and how this is related to interleukin (IL)-2 production.Results: Healthy older adults have reduced lymphocyte surface expression and lower circulating plasma Trx-1 concentrations. Using buthionine sulfoximine to deplete intracellular glutathione in Jurkat T cells we show that cell surface Trx-1 is lowered, secretion of Trx-1 is decreased and the response to the lectin phytohaemagglutinin measured as IL-2 production is also affected. These effects are recapitulated by another glutathione depleting agent, diethylmaleate.Conclusion: Together these data suggest that a relationship exists between the intracellular redox compartment and Trx-1 proteins. Loss of lymphocyte surface Trx-1 may be a useful biomarker of healthy ageing. © 2013 Carilho Torrao et al.; licensee Chemistry Central Ltd

Lipid (per) oxidation in mitochondria:an emerging target in the ageing process?

Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to control processes including cell proliferation, metabolism, inflammation and apoptosis. Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation. In addition, senescent cells, which are known to contribute significantly to age-related pathologies, are also associated with impaired mitochondrial function and changes in lipid metabolism. Therapeutic targeting of dysfunctional mitochondrial and pathological lipid metabolism is an emerging strategy for alleviating their negative impact during ageing and the progression to age-related diseases. Such therapies could include the use of drugs that prevent mitochondrial uncoupling, inhibit inflammatory lipid synthesis, modulate lipid transport or storage, reduce mitochondrial oxidative stress and eliminate senescent cells from tissues. In this review, we provide an overview of lipid structure and function, with emphasis on mitochondrial lipids and their potential for therapeutic targeting during ageing and age-related disease