Nutritional Management in Polycystic Ovary Syndrome: Challenges and opportunities

PCOS is one of the most common endocrine diseases affecting women of reproductive age. Its etiology remains unresolved but it is thought to have a genetic basis as well as interactions with other environmental factors. This disease is diagnosed through the Rotterdam 2003 criteria but there is no definite treatment for the disorder. However, cure involves targeting the multiple symptoms of PCOS where weight loss is the first-line intervention. Obesity may not be the universal feature of PCOS, but studies have shown that there is a high prevalence among diseased females. Since the patients are more likely to be obese, they are also more likely to develop insulin resistance. The proper diet for PCOS thus targets these two characteristics of the disorder and through their management, the other symptoms of PCOS including hirsutism, acne and infertility are targeted. Saturated fats consumption should be reduced to a minimum whereas the unsaturated fat intake must be balanced with the carbohydrate and protein intake. Carbohydrate intake should not be abundant in the diet because high GI foods prove to reduce insulin sensitivity and increase the risk of type 2 diabetes. As for the protein intake, it should not exceed 20% of the total macronutrient calorie intake. A healthy lifestyle must be followed which includes at least 30 minutes of exercise, five times a week. A properly managed diet combined with a balanced lifestyle addresses insulin resistance, cardiovascular health and metabolism, all of which target PCOS symptoms and alleviate them

Finding the right fit: Enhancing the academic-industry link in the sector for Nutrition undergraduates – a pilot study

Academic learning experience prepares students for professional life, enriches their scientific-evidence knowledge, whereas laboratory practicals upskill their experiences applying theory into “real world” scenarios. As most undergraduate programmes are not offering placement year, students rely heavily on their initiatives and networking to maximise their continuous professional development (CPD). This study evaluated the supporting mechanisms between academia and industry/ sector and examined staff and students’ perceptions of existing academia-industry collaborations. An online survey was designed to record perceptions of undergraduate’s nutrition students. This was followed by focus groups to establish students’ perceptions of the relevant professional organisations and their related experiences outside academia. Captured students’ feedback together with the nutrition teaching academics responses in individual semi-structured interviews have portrayed the current academic-industry links, the perceived challenges/barriers and probed sensible roadmap. Six themes uncovered the need for extra nutrition-related work experiences, while the students’ perceptions reflected their learning through course progression, awareness of external opportunities and underpinned that graduate readiness improved progressively with years spent in study. The Academics’ interviews recognized the limited academic-industry collaborations and underpinned many barriers faced; more “top-down” support was identified as a strategy to enhance external links. The study provides a clear lens into the present academic-industry links within the nutrition programmes and ascertained the perceived challenges experienced by students and academics. Collaborations and centralised university communications shall promote a better university experience. Equally, staff-student partnerships will facilitate a new approach to understand both staff and students’ perspectives and enhance learning experiences within the sector

Attitudinal Determinants of diet and lifestyle among African and Caribbean women living in the UK : study design and rationale

The aim of this article is to describe the rationale and design of a cross-sectional study that investigated the influence of attitudinal factors on diet and lifestyle of African and Caribbean women living in the UK. The results of the study will be presented elsewhere. African and Caribbean women are at high risk of obesity which exacerbates health inequalities. In the UK, little work has been carried out to better understand attitudinal factors that contribute towards obesity, lifestyle and health practice amongst this group. Methods: The study applied a comprehensive questionnaire to capture socio-demographic data and explore general attitudes towards diet and lifestyle of African and Caribbean women. Dietary data were collected using triple-pass 24-hour recalls. In addition, all participants had anthropometric measures, blood pressure and biochemical indices assessed using standardised methods. Discussion: Potential strengths and limitations of the current study design, exploring health, diet, and lifestyle habits and the contextual influence on these practices among African and Caribbean in the UK are discussed. Findings from this study will contribute to the understanding of food and health practices, the role of socio-cultural factors and potential barriers and facilitators to the adoption of a healthy lifestyle, which could reduce the risk of cardiovascular disease, obesity, and type 2 diabetes, all of which have increased prevalence in these communities

REVE 2021: 9th International Workshop on Reverse Variability Engineering

Software Product Line (SPL) migration remains a challenging endeavour. From organizational issues to purely technical challenges, there is a wide range of barriers that complicates SPL adoption. This workshop aims to foster research about making the most of the two main inputs for SPL migration: 1) domain knowledge and 2) legacy assets. Domain knowledge, usually implicit and spread across an organization, is key to define the SPL scope and to validate the variability model and its semantics. At the technical level, domain expertise is also needed to create or extract the reusable software components. Legacy assets can be, for instance, similar product variants (e.g., requirements, models, source code, etc.) that were implemented using ad-hoc reuse techniques such as clone-and-own. More generally, the workshop REverse Variability Engineering attracts researchers and practitioners contributing to processes, techniques, tools, or empirical studies related to the automatic, semi-automatic or manual extraction or refinement of SPL assets

Оценка гидрогеодинамического влияния режима эксплуатации скважин на основе статистических функций

Исследовано воздействие работы эксплуатационных скважин полигона захоронения промышленных отходов Сибирского химического комбината на колебание напоров в наблюдательных скважинах и выделение частотных составляющих техногенного и природного колебаний в спектре. Показана возможность использования функции взаимной корреляции и Фурье-анализа для оценки гидрогеодинамического влияния режима работы эксплуатационных скважин

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury

Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing. Clinical use of APC, however, is limited by its immunogenicity and its anticoagulant activity. We show that a class of small molecules termed “parmodulins” that act at the cytosolic face of PAR1 stimulates APC-like cytoprotective signaling in endothelium. Parmodulins block thrombin generation in response to inflammatory mediators and inhibit platelet accumulation on endothelium cultured under flow. Evaluation of the antithrombotic mechanism showed that parmodulins induce cytoprotective signaling through Gβγ, activating a PI3K/Akt pathway and eliciting a genetic program that includes suppression of NF-κB–mediated transcriptional activation and up-regulation of select cytoprotective transcripts. STC1 is among the up-regulated transcripts, and knockdown of stanniocalin-1 blocks the protective effects of both parmodulins and APC. Induction of this signaling pathway in vivo protects against thromboinflammatory injury in blood vessels. Small-molecule activation of endothelial cytoprotection through PAR1 represents an approach for treatment of thromboinflammatory disease and provides proof-of-principle for the strategy of targeting the cytoplasmic surface of GPCRs to achieve pathway selective signaling

Internet-based search of randomised trials relevant to mental health originating in the Arab world

BACKGROUND: The internet is becoming a widely used source of accessing medical research through various on-line databases. This instant access to information is of benefit to busy clinicians and service users around the world. The population of the Arab World is comparable to that of the United States, yet it is widely believed to have a greatly contrasting output of randomised controlled trials related to mental health. This study was designed to investigate the existence of such research in the Arab World and also to investigate the availability of this research on-line. METHODS: Survey of findings from three internet-based potential sources of randomised trials originating from the Arab world and relevant to mental health care. RESULTS: A manual search of an Arabic online current contents service identified 3 studies, MEDLINE, EMBASE, and PsycINFO searches identified only 1 study, and a manual search of a specifically indexed, study-based mental health database, PsiTri, revealed 27 trials. CONCLUSION: There genuinely seem to be few trials from the Arab world and accessing these on-line was problematic. Replication of some studies that guide psychiatric/psychological practice in the Arab world would seem prudent