1,131 research outputs found
A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins avß3, avß5, avß6, avß8, a5ß1, aIIbß3, using homogenous ELISA-like solid phase binding assay.Postprint (published version
Highly effective fat suppression in clinical T1-weighted imaging of ischemic and non-ischemic heart disease with DeSPAIR
Phase sensitive inversion recovery with simultaneous dark fat rendering by virtual chemical inversion
Assessment of semi-quantitative parameters for visual interpretation of stress-perfusion CMR in obstructive coronary artery disease
The relationship of the transmural extent of T2-edema compared with the transmural extent of infarction: implications for the assessment of the area-at-risk
Assessment of semi-quantitative parameters for visual interpretation of stress-perfusion CMR in obstructive coronary artery disease
Time course of the effect of ferumoxytol on T1-relaxation times of blood, liver, myocardium, and acute infarction
Moving lessons: teaching sociology through embodied learning in the HE classroom
This chapter outlines an approach to classroom teaching that makes use of physical movement alongside more traditional lecturing methods when delivering lessons on abstract theoretical material. It develops the notion of embodied learning as a 'physical metaphor', outlining some examples of this practice that we have used in our recent work with a class of first year undergraduates. We argue that conceptualising students as embodied subjects, whose capacity to learn extends through and beyond their physical selves, educators are able to enhance classroom delivery by diversifying teaching activities and creating opportunities for enjoyable and memorable learning experiences. We advocate the reflexive, contextually-sensitive and level-
appropriate use of this method, arguing that despite some limitations it can animate students' understanding of academic ideas in uniquely personalised ways
The relationship of the transmural extent of T2-edema compared with the transmural extent of infarction: implications for the assessment of the area-at-risk
Assessment and improvement of image homogeneity in black-blood T2-weighted turbo spin-echo CMR
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